Protein

MCA_01284_1

Length
442 amino acids

Gene name: PDB1B

Description: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

Browser: contigA:4038290-4039619-

RNA-seq: read pairs 4247, FPKM 118.5, percentile rank 81.6% (100% = highest expression)

Protein function

Annotation:PDB1BPyruvate dehydrogenase E1 component subunit beta, mitochondrial
KEGG:K00167BCKDHB 2-oxoisovalerate dehydrogenase E1 component beta subunit [EC:1.2.4.4]
EGGNOG:0PJGZFG08622.1Dehydrogenase
SGD closest match:S000000425PDB1Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
CGD closest match:CAL0000175775PDB1Pyruvate dehydrogenase (Acetyl-transferring) subunit E1 beta

Protein alignments

%idAln lengthE-value
MIA_06397_168.81%4200.0MIA_06397_1
Q6C2U7_YARLI60.86%4420.0YALI0F05038p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F05038g PE=4 SV=1
A0A167D8X3_9ASCO62.19%4020.0Pyruvate dehydrogenase (Acetyl-transferring) subunit E1 beta OS=Sugiyamaella lignohabitans GN=PDB1 PE=4 SV=1
A0A0J9XAI0_GEOCN62.22%4050.0Similar to Saccharomyces cerevisiae YBR221C PDB1 E1 beta subunit of the pyruvate dehydrogenase (PDH) complex OS=Geotrichum candidum GN=BN980_GECA07s02045g PE=4 SV=1
A0A060T7F9_BLAAD63.91%3996e-179ARAD1D02926p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D02926g PE=4 SV=1
A0A1E4TGW6_9ASCO62.37%3965e-172Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_23982 PE=4 SV=1
A0A1E3PNF4_9ASCO54.34%4032e-155Thiamin diphosphate-binding protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_73941 PE=4 SV=1
UniRef50_A0A0B7MP5154.78%3872e-145Uncharacterized protein n=87 Tax=Eukaryota TaxID=2759 RepID=A0A0B7MP51_9FUNG
ODPB_YEAST34.16%3632e-52Pyruvate dehydrogenase E1 component subunit beta, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PDB1 PE=1 SV=2
Q5A5V6_CANAL30.54%4422e-52Pyruvate dehydrogenase (Acetyl-transferring) subunit E1 beta OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PDB1 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9986
Predicted cleavage: 37

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 442

Detailed signature matches

  1. Domain IPR029061
    Thiamin diphosphate-binding fold
    1. SSF52518 (Thiamin d...)
  2. Domain IPR005475
    Transketolase-like, pyrimidine-binding domain
    1. PF02779 (Transket_pyr)
    2. SM00861 (Transket_p...)
  3. Domain IPR009014
    Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II
    1. G3DSA:3.40.50...
    2. SSF52922 (TK C-term...)
  4. Domain IPR033248
    Transketolase, C-terminal domain
    1. PF02780 (Transketol...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. cd07036 (TPP_PYR_E1...)

Residue annotation

  1. alpha subunit inte...
  2. TPP binding site c...
  3. heterodimer interf...

Protein sequence

>MCA_01284_1
MLSRTLIRSSLKYNSKLASNSLRATTRNFSQTQSWSKSILIPESSPNNITYSEAPFLYKTAQQALSDPEVIEALSKKNSA
ESSPDPTEVNVGSATKLNLYQAINDALRIALDTHPNAILFGEDVAFGGVFRCSMGLQEMFGAHRVFNTPLTEQGIVGFGV
GYAATSPTMFDDYDTSTGNEEVDRCIAIAEIQFSDYVFPAFDQIVNEAAKYRYRGADHFNVGGLTIRMPCGNVGHGAMYH
SQSGEAFFAHSPGIKVVMPRSPLQAKGLLLSAIRDKNPVIFMEPKMLYRASVEYVPNEDYELPLGKAQVVQEGSDVTIVT
YGTPVYIAVKAAELAAQELKNKDGSKVSVEVIDLRTVHPWDRETVVNSVNKTGRAIVLHEAPKTNSISSDVAAEILQRCF
LRLESPIERVTGWDVHMPLQFEDLIAPNVTRVFHAIKKTINY

GO term prediction

Biological Process

GO:0008152 metabolic process

Molecular Function

GO:0003824 catalytic activity

Cellular Component

None predicted.