Protein

MCA_01264_1

Length
688 amino acids

Gene name: DUR1,2

Description: Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities

Browser: contigA:3970111-3972178-

RNA-seq: read pairs 355, FPKM 6.4, percentile rank 19.6% (100% = highest expression)

Protein function

Annotation:DUR1,2Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities
KEGG:K01968E6.4.1.4A 3-methylcrotonyl-CoA carboxylase alpha subunit [EC:6.4.1.4]
EGGNOG:0PHUIFG08688.1carboxylase
SGD closest match:S000000412DUR1,2Urea amidolyase
CGD closest match:CAL0000184290DUR1,2Bifunctional urea carboxylase/allophanate hydrolase

Protein alignments

%idAln lengthE-value
MIA_02897_179.02%6960.0MIA_02897_1
A0A0J9X8S2_GEOCN74.20%6900.0Similar to Saccharomyces cerevisiae YBR208C DUR1,2 Urea amidolyase OS=Geotrichum candidum GN=BN980_GECA05s04498g PE=4 SV=1
UniRef50_A0A0J9X8S274.20%6900.0Similar to Saccharomyces cerevisiae YBR208C DUR1,2 Urea amidolyase n=6 Tax=saccharomyceta TaxID=716545 RepID=A0A0J9X8S2_GEOCN
A0A060T2N7_BLAAD64.64%6730.0ARAD1A10010p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A10010g PE=4 SV=1
A0A161HJ91_9ASCO62.66%6830.0Bifunctional urea carboxylase/allophanate hydrolase OS=Sugiyamaella lignohabitans GN=DUR1,2 PE=4 SV=1
A0A1E4TEI9_9ASCO60.61%6830.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_24944 PE=4 SV=1
Q6CEM0_YARLI58.30%7170.0YALI0B14619p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B14619g PE=4 SV=1
A0A1D8PDC6_CANAL42.26%4331e-114Bifunctional urea carboxylase/allophanate hydrolase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=DUR1,2 PE=4 SV=1
A0A1E3PSD7_9ASCO42.40%4345e-109Urea amidolyase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48988 PE=4 SV=1
DUR1_YEAST41.76%4315e-106Urea amidolyase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DUR1,2 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9519
Predicted cleavage: 30

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 100 200 300 400 500 600 688

Detailed signature matches

  1. Domain IPR016185
    Pre-ATP-grasp domain
    1. SSF52440 (PreATP-gr...)
  2. Domain IPR011764
    Biotin carboxylation domain
    1. PS50979 (BC)
  3. Domain IPR005481
    Biotin carboxylase-like, N-terminal domain
    1. PF00289 (Biotin_carb_N)
  4. Domain IPR011761
    ATP-grasp fold
    1. PS50975 (ATP_GRASP)
  5. Domain IPR005479
    Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
    1. PF02786 (CPSase_L_D2)
    2. PS00867 (CPSASE_2)
  6. Domain IPR013815
    ATP-grasp fold, subdomain 1
    1. G3DSA:3.30.14...
  7. Domain IPR011054
    Rudiment single hybrid motif
    1. SSF51246 (Rudiment ...)
  8. Domain IPR005482
    Biotin carboxylase, C-terminal
    1. SM00878 (Biotin_car...)
    2. PF02785 (Biotin_carb_C)
  9. Domain IPR011053
    Single hybrid motif
    1. SSF51230 (Single hy...)
  10. Domain IPR000089
    Biotin/lipoyl attachment
    1. PS50968 (BIOTINYL_L...)
    2. PF00364 (Biotin_lipoyl)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:2.40.50...
  2. G3DSA:3.30.47...
  3. G3DSA:3.40.50.20
  4. SSF56059 (Glutathio...)
  5. cd06850 (biotinyl_d...)

Residue annotation

  1. carboxyltransferas...
  2. biotinylation site...

Protein sequence

>MCA_01264_1
MSKTTIVAKPLRSLFIANRGEIVHRISRTASRMGIDTTTVYTTPDAQLPSATSAFNNLSLGDATNGYINIDNVVNTAKDA
GCDSIHPGYGFLSENATFAKKVRDAGLVFVGPPQQAIESMGSKSASKEIMINANVPVVPGYHGSNQDASFLAEQAEKIGF
PVLIKAVLGGGGKGMRIVNSAADFPAALESAKSEARSSFGDDNVLVEKYIKTPRHIEVQVFADKFGNVVALGERDCSVQR
RHQKVLEESPAPGLDQETREQLWEKARLAARAVNYEGAGTVEFIFDNDTNEFYFMEMNTRLQVEHPVTEAVTNTDLVEWQ
LLVAAGFPLPKTQEEIKITGHAIEARVYCEDAFKDFLPSSGKIVHLQEPTTGEPRLDVTFKQNSTVSSLYDPMIGKLIVK
GETRDEALRKLRRALQEFEIVGPVTNIEFVKRVVEHDAFGGENPVGLETGFITKNKDALIAPIIIPKEVYAQAALSQIAS
KSNPLDSFSRFAGFSNSWSFSQVKTFEFKDPLNPDAKATIVKTLQTGPHSYKVLVGDDPTPLVVDSVYYSEVPGSKKLHI
RFKDSQYVNTVVPTLALDSSIHVFHKGTHFVVEQPQPKWLQTALGVKETKNSVVAPMPCKVVRLSIEPGQTVEKDQELLV
IESMKMETVIRSPQAGVVKRVAHDAGDIVKQGTLLVEFEGQDGEEAKE

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003824 catalytic activity
GO:0004075 biotin carboxylase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding

Cellular Component

None predicted.