Protein

MCA_01224_1

Length
389 amino acids

Browser: contigA:3855218-3856388+

RNA-seq: read pairs 675, FPKM 21.4, percentile rank 43.1% (100% = highest expression)

Protein function

KEGG:K13989DERL2_3 Derlin-2/3
EGGNOG:0PIMPFG02601.1ER-associated proteolytic system protein Der1
SGD closest match:S000000405DER1Degradation in the endoplasmic reticulum protein 1

Protein alignments

%idAln lengthE-value
A0A0J9XAV0_GEOCN44.35%1242e-26Derlin OS=Geotrichum candidum GN=BN980_GECA07s04036g PE=3 SV=1
UniRef50_A0A0J9XAV044.35%1243e-23Derlin n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XAV0_GEOCN
MIA_00326_144.14%1117e-19MIA_00326_1
Q6C075_YARLI35.37%1478e-18Derlin OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F27225g PE=3 SV=1
A0A060T8Q0_BLAAD37.88%1329e-16Derlin OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C38610g PE=3 SV=1
DER1_YEAST27.59%872e-06Degradation in the endoplasmic reticulum protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DER1 PE=1 SV=3

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2909

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 389

Detailed signature matches

  1. Domain IPR022764
    Peptidase S54, rhomboid domain
    1. SSF144091 (Rhomboid...)
    2. G3DSA:1.20.15...
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. Coil
  3. NON_CYTOPLASM... (N...)
  4. PF04511 (DER1)
  5. SIGNAL_PEPTIDE (Sig...)
  6. SIGNAL_PEPTID... (S...)
  7. SIGNAL_PEPTID... (S...)
  8. SIGNAL_PEPTID... (S...)
  9. TMhelix
  10. TRANSMEMBRANE (Tran...)
  11. mobidb-lite (disord...)

Protein sequence

>MCA_01224_1
MDRMPIDWFLEMPPITRLWVLGIAATSIAEQFHLIGPLQLLYSSSQVFKHGEYWRLVTCFLYFGRLNVNLFFNVYFVIRY
SRIIEESMGGTGMHLGGAGRHQLFEGQLNNENDDQRMLMQLLGAGGENNNNNNNNGENENGAGGENEGAVGGIKHFLFEF
FGLGNIATLNYLWMLVVIGSMLIIVSSYFQILGFLGPMLSGSLIYVWARRNPDVVLSFFGLFVFSAPYLPWIMLLFSSVM
NDSGNSGGSIKKWLQSNTDLIAICVGHIYFFFEDIFPALADGRRPLAPPWETWHFERVVEQAPPEEQNENDNTNQQEQPI
NNNNDNYNTSHLQDNVRPFDKEKSKKDSSIIDTTSTFEASSSFSEKQKIDASTSLENQREKSQQEVDSN

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0004252 serine-type endopeptidase activity

Cellular Component

GO:0016021 integral component of membrane