Protein

MCA_01209_1

Length
605 amino acids

Gene name: RIO1

Description: Serine/threonine protein kinase Rio1; in S. cerevisiae involved in cell cycle regulation and rDNA integrity.

Browser: contigA:3828970-3830788+

RNA-seq: read pairs 662, FPKM 13.5, percentile rank 31.6% (100% = highest expression)

Protein function

Annotation:RIO1Serine/threonine protein kinase Rio1; in S. cerevisiae involved in cell cycle regulation and rDNA integrity.
KEGG:K07178RIOK1 RIO kinase 1 [EC:2.7.11.1]
EGGNOG:0PG2FRIO1Serine threonine-protein kinase rio1
SGD closest match:S000005645RIO1Serine/threonine-protein kinase RIO1
CGD closest match:CAL0000187360orf19.2320Serine/threonine-protein kinase RIO1

Protein alignments

%idAln lengthE-value
MIA_00513_156.61%4844e-168MIA_00513_1
A0A0J9X9X0_GEOCN55.13%4485e-145Serine/threonine-protein kinase RIO1 OS=Geotrichum candidum GN=BN980_GECA06s02738g PE=3 SV=1
UniRef50_A0A0J9X9X055.13%4481e-141Serine/threonine-protein kinase RIO1 n=2 Tax=Saccharomycetales TaxID=4892 RepID=A0A0J9X9X0_GEOCN
A0A1E3PS51_9ASCO50.21%4867e-140RIO1-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45705 PE=4 SV=1
A0A060T2E4_BLAAD52.63%4181e-137Serine/threonine-protein kinase RIO1 OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C24662g PE=3 SV=1
Q6CB28_YARLI52.35%4051e-133Serine/threonine-protein kinase RIO1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C22385g PE=3 SV=1
A0A167FD44_9ASCO54.34%3922e-130Protein kinase RIO1 OS=Sugiyamaella lignohabitans GN=RIO1 PE=4 SV=1
A0A1E4TDH8_9ASCO55.05%3279e-119Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_4442 PE=4 SV=1
Q59WI0_CANAL47.67%3652e-97Serine/threonine-protein kinase RIO1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.2320 PE=3 SV=1
RIO1_YEAST46.20%3551e-92Serine/threonine-protein kinase RIO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RIO1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0752

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 605

Detailed signature matches

  1. Family IPR017407
    Serine/threonine-protein kinase Rio1
    1. PIRSF038147 (STPK_RIO1)
  2. Domain IPR011009
    Protein kinase-like domain
    1. SSF56112 (Protein k...)
  3. Domain IPR000687
    RIO kinase
    1. SM00090 (rio_2)
  4. Domain IPR000719
    Protein kinase domain
    1. PS50011 (PROTEIN_KI...)
  5. SITE IPR018935
    RIO kinase, conserved site
    1. PS01245 (RIO1)
  6. SITE IPR008266
    Tyrosine-protein kinase, active site
    1. PS00109 (PROTEIN_KI...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.10.51...
  3. G3DSA:3.30.20...
  4. PF01163 (RIO1)
  5. cd05147 (RIO1_euk)
  6. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...

Protein sequence

>MCA_01209_1
MTSDIQGESKSNFTNTINDTEFPINEIQNLTINEEESTDQSPMDQEEYSDEDLDEFIDADFMDSEFSHDISARGSGTLTH
QYNRQKSLAQTNSAKPRFNPKGGSAPATALAAKELKEKIAAAKSASDEATLSKLMASRIKINDGYVGGDYHANASGTGGQ
LDRSNRATTEKVLDPRTRMILFKMINRGVVYEINGCISTGKEANVYHALTEDEQHRAIKIYKTSILVFKDRDKYVTGEFR
FRSGYSKHNPRKMVKLWAEKEFRNLRRIGLNSDIPVPQPLFLQMHVLTMEFLGDKKGWPSPRLRDADHLINGVEEYQTLY
YQLLSYMRLLYQQCRLVHADLSEYNILYHENKLWIIDVSQSVELEHPQSLNFLRMDIKNVTDFFNKKGCEISFSERTIFR
FITTSDLYSTFFALKADEEHTEEEIAMSLYWKKKITSIGSIENETTPFLMELVEAIPAEDITEQDALDDAVFREVFIPRN
LEDVLKNVHEADLDRKIGQKQLAFGDLVYESIKEKTNPFLKTDDDEEDYSEDGEENEDEENEDEDEDESSQNGGEHKGDR
KFSDREANKLRKKQIKEQARAKREKKVKKHVKKKLNQAPATKHKK

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding

Cellular Component

None predicted.