Protein

MCA_01156_2

Length
544 amino acids

Gene name: FRE3A

Description: Ferric reductase transmembrane component 3

Browser: contigA:3666750-3668385-

RNA-seq: read pairs 595, FPKM 13.5, percentile rank 31.6% (100% = highest expression)

Protein function

Annotation:FRE3AFerric reductase transmembrane component 3
EGGNOG:0PHSNFG01789.1Ferric-chelate reductase
SGD closest match:S000005908FRE3Ferric reductase transmembrane component 3
CGD closest match:CAL0000177334FRE10Fre10p

Protein alignments

%idAln lengthE-value
MIA_05670_142.94%5456e-161MIA_05670_1
Q6CF26_YARLI35.66%5442e-121YALI0B10846p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B10846g PE=4 SV=1
UniRef50_Q6CF2635.66%5444e-118YALI0B10846p n=2 Tax=Yarrowia lipolytica TaxID=4952 RepID=Q6CF26_YARLI
A0A0J9XI25_GEOCN36.00%5255e-120Similar to Saccharomyces cerevisiae YOR384W FRE5 Putative ferric reductase with similarity to Fre2p OS=Geotrichum candidum GN=BN980_GECA16s00164g PE=4 SV=1
A0A167FY66_9ASCO33.04%5661e-99Fre2p OS=Sugiyamaella lignohabitans GN=FRE2 PE=4 SV=1
A0A060SVU5_BLAAD34.12%5513e-95ARAD1A00286p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A00286g PE=4 SV=1
A0A1E4TLJ4_9ASCO31.27%5502e-82Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30726 PE=4 SV=1
A0A1E3PIN1_9ASCO29.49%5296e-81Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83263 PE=4 SV=1
Q59PA1_CANAL30.84%5482e-78Fre10p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=FRE10 PE=4 SV=1
FRE3_YEAST30.81%5293e-68Ferric reductase transmembrane component 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FRE3 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9861
Predicted cleavage: 58

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 450 500 544

Detailed signature matches

  1. Domain IPR013130
    Ferric reductase transmembrane component-like domain
    1. PF01794 (Ferric_reduct)
  2. Domain IPR017927
    Ferredoxin reductase-type FAD-binding domain
    1. PS51384 (FAD_FR)
  3. Domain IPR013112
    FAD-binding 8
    1. PF08022 (FAD_binding_8)
  4. Domain IPR013121
    Ferric reductase, NAD binding domain
    1. PF08030 (NAD_binding_6)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. G3DSA:2.40.30.10
  3. G3DSA:3.40.50.80
  4. NON_CYTOPLASM... (N...)
  5. SFLDG01168 (Ferric_...)
  6. SFLDS00052 (Ferric_...)
  7. SSF52343 (Ferredoxi...)
  8. TMhelix
  9. TRANSMEMBRANE (Tran...)
  10. cd06186 (NOX_Duox_l...)

Residue annotation

  1. FAD binding pocket...
  2. FAD binding motif ...
  3. beta-alpha-beta st...
  4. NAD pyrophosphate ...
  5. NAD binding pocket...
  6. NADP ribose bindin...

Protein sequence

>MCA_01156_2
MISNFVTRTMPKVTKSLFKVNLVILFRKRISLPALAGYRHDTPLKYGIFNASLPTRAQSIILFFYFTITVTFLSIGYDLY
DGNTRYQTKTIQFTRYLGDRAGILATAHLPMIFLFAGRNNIMLWLTNWSFTTMSVYHKWISRMLFVLVAIHGACFYTHYK
LLNKFQLMEELYVAWGIVAAISVTLIIVCSIRHIRERVYDLFLLGHQILVILFVVGAWRHLQPHGYLEWMYASIAIWAFD
RVCRVARVALSGLRARANCKVYSNEIIKMKIDYSSTWLPRAGSYVFVSFLKPTWKFWESHPFSIYPSTVAGEENKLVVCL
KKANGKTKQLVDYLSTNKESYDGGIIPVWLDGPYGQRFPIEKSDTVVFIAGGMGITAIYSYAVEMMKISEKKHLKFNWII
QDESYTDWFRDELEYLIMSGLMEVSIYISRSKKKLLEKGNINNNIDKSNSNNAKCQQQKNIEQEKIENHQQPKEWDLKIK
SHIYYERPNLTGLVDSAISEAVPGSIAFMTCGPDRMNDEVRKIITSELKEGRGNIDLFTESFSY

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

None predicted.