Protein

MCA_01093_1

Length
1,025 amino acids

Gene name: UBA1

Description: Ubiquitin-activating enzyme E1; involved in ubiquitin-mediated protein degradation and essential for viability; protein abundance increases in response to DNA replication stress

Browser: contigA:3485430-3488703-

RNA-seq: read pairs 11391, FPKM 137.2, percentile rank 83.7% (100% = highest expression)

Protein function

Annotation:UBA1Ubiquitin-activating enzyme E1; involved in ubiquitin-mediated protein degradation and essential for viability; protein abundance increases in response to DNA replication stress
KEGG:K03178UBE1 ubiquitin-activating enzyme E1 [EC:6.2.1.45]
EGGNOG:0PFZCFG09689.1ubiquitin-activating enzyme E1
SGD closest match:S000001693UBA1Ubiquitin-activating enzyme E1 1
CGD closest match:CAL0000188696UBA1E1 ubiquitin-activating protein

Protein alignments

%idAln lengthE-value
MIA_00605_181.38%10310.0MIA_00605_1
A0A0J9X3V6_GEOCN77.69%10220.0Similar to Saccharomyces cerevisiae YKL210W UBA1 Ubiquitin activating enzyme (E1) OS=Geotrichum candidum GN=BN980_GECA02s05378g PE=3 SV=1
A0A060TC90_BLAAD68.82%10230.0ARAD1D37774p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D37774g PE=3 SV=1
A0A167EXX9_9ASCO68.49%10250.0E1 ubiquitin-activating protein UBA1 OS=Sugiyamaella lignohabitans GN=UBA1 PE=3 SV=1
A0A1E3PQM0_9ASCO66.41%10270.0Ubiquitin-activating enzyme E1 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_80903 PE=3 SV=1
Q6C6V1_YARLI63.87%10240.0YALI0E06017p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E06017g PE=3 SV=1
UBA1_YEAST64.59%10250.0Ubiquitin-activating enzyme E1 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UBA1 PE=1 SV=2
UniRef50_P2251564.59%10250.0Ubiquitin-activating enzyme E1 1 n=293 Tax=Eukaryota TaxID=2759 RepID=UBA1_YEAST
A0A1D8PKJ3_CANAL63.20%10300.0E1 ubiquitin-activating protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=UBA1 PE=3 SV=1
A0A1E4TKQ2_9ASCO60.41%10180.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_56027 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0023

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 800 900 1025

Detailed signature matches

  1. Family IPR000011
    Ubiquitin/SUMO-activating enzyme E1
    1. PR01849 (UBIQUITINACT)
  2. Family IPR018075
    Ubiquitin-activating enzyme E1
    1. TIGR01408
  3. Domain IPR000594
    THIF-type NAD/FAD binding fold
    1. PF00899 (ThiF)
    2. SSF69572 (Activatin...)
  4. Domain IPR032418
    Ubiquitin-activating enzyme E1, FCCH domain
    1. PF16190 (E1_FCCH)
  5. Domain IPR032420
    Ubiquitin-activating enzyme E1, four-helix bundle
    1. PF16191 (E1_4HB)
  6. Domain IPR019572
    Ubiquitin-activating enzyme, catalytic cysteine domain
    1. PF10585 (UBA_e1_thi...)
  7. Domain IPR018965
    Ubiquitin-activating enzyme E1, C-terminal
    1. SM00985 (UBA_e1_C_a_2)
    2. PF09358 (E1_UFD)
  8. SITE IPR033127
    Ubiquitin-activating enzyme E1, Cys active site
    1. PS00865 (UBIQUITIN_...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. G3DSA:3.40.50...
  3. NON_CYTOPLASM... (N...)
  4. TRANSMEMBRANE (Tran...)
  5. cd01490 (Ube1_repeat2)
  6. cd01491 (Ube1_repeat1)

Residue annotation

  1. interdomain dimer ...
  2. putative ATP bindi...
  3. putative substrate...
  4. catalytic residue ...

Protein sequence

>MCA_01093_1
MGSDKMDVDKPEGEIDESLYSRQLYVLGAEAMKKMSASNVLVVGLKGLGVEIAKNVALAGVKSITLHDPKPTELTDLSSQ
FFLTTEDIGKPRDKATAAKLAELNQYVPVKVLEGDILDETTLSQFQVVVLTEATLETQVKINQFTHRTNRGFISTDTRGL
FGNVFVDLGAEFTVTDQTGEEPHTGIISDIDSAGNVSILDDSRHGLQDGDWVKFSEVEGLEALNGEQHYEVKVTGPFGFN
IGDLSGMGTYTKGGIFTQVKKPVKLSFQSLEEQIKKPEFLVSDFAKFDRPNILHVGFLALHGFYNKHERLPYPHDEEDAN
ELVILAQNVKAGQTDLGEFEIDEKIIKQLSYQARGDIPAMNAFFGGLVAQEVLKAVSGKFGPIKQWMYFDSLESLPAKIT
LDKETTAPIGSRYDNQIAVFGKEFVERIQNLKVFLVGSGAIGCEMLKNWAMMGLGSGPNGKIFITDNDSIEKSNLNRQFL
FRSKDVGNQKSEVAAAAVINMNPDLAGHIEAKQDKVGPETENIFDDKFWHNLDLVTNALDNIEARTYVDRRCVFFKKPLL
ESGTLGTKGNVQVVFPFLTESYSSSQDPPEKSIPLCTLRSFPNKIDHTIAWAKSLFQGYFIDNPETVNLYLSDPEFNKNF
LEKSGDQKTTLETLKDYLVDSRPLTFEECISWARLEFEKKFVNDIKQLLYNFPKDAVTSTGAPFWSGPKRAPTPAVFDIN
NEDHFNFIVAAANLRAFNYGLKGGADLETYKKVIENTKIPEFTPASNVKIQVEENEEPSNDPTQFDGDDVIENLKREIPS
PKSLAGFKLDVVEFEKDDDTNHHIDFITAASNLRAINYQIEPADRLKTKFIAGRIIPAIATTTALVTGLVCLELYKVVDG
ENKTIEDFKNGFISLALPFFGFSEPVVSPKSKYKAADGTEKTIDKIWSRYDIYGNPTLGELIEKFEKEEGLEISMLSSGT
TLLFASFLMNKHKPRLAMKMSEVIESVSGKPLGDHVKTLVLEICADDAEGNEVEDLPFIALHIKE

GO term prediction

Biological Process

GO:0006464 cellular protein modification process

Molecular Function

GO:0008641 small protein activating enzyme activity

Cellular Component

None predicted.