Protein

MCA_01070_1

Length
1,240 amino acids

Gene name: UBP15

Description: Ubiquitin carboxyl-terminal hydrolase 15; Ubiquitin-specific protease involved in protein deubiquitination

Browser: contigA:3398658-3402613+

RNA-seq: read pairs 9405, FPKM 93.6, percentile rank 77.6% (100% = highest expression)

Protein function

Annotation:UBP15Ubiquitin carboxyl-terminal hydrolase 15; Ubiquitin-specific protease involved in protein deubiquitination
KEGG:K11838USP7 ubiquitin carboxyl-terminal hydrolase 7 [EC:3.4.19.12]
EGGNOG:0PF84FGSG_07382ubiquitin carboxyl-terminal hydrolase
SGD closest match:S000004920UBP15Ubiquitin carboxyl-terminal hydrolase 15
CGD closest match:CAL0000182786orf19.1777Ubiquitin-specific protease

Protein alignments

%idAln lengthE-value
MIA_01676_153.01%12640.0MIA_01676_1
A0A0J9XH58_GEOCN48.86%11010.0Similar to Saccharomyces cerevisiae YMR304W UBP15 Ubiquitin-specific protease involved in protein deubiquitination OS=Geotrichum candidum GN=BN980_GECA17s01473g PE=3 SV=1
UniRef50_A0A0J9XH5848.86%11010.0Similar to Saccharomyces cerevisiae YMR304W UBP15 Ubiquitin-specific protease involved in protein deubiquitination n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XH58_GEOCN
A0A060T566_BLAAD46.63%11730.0ARAD1B08074p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B08074g PE=3 SV=1
A0A167DWA4_9ASCO46.99%11470.0Ubp15p OS=Sugiyamaella lignohabitans GN=UBP15 PE=3 SV=1
Q6C8W6_YARLI39.97%11910.0YALI0D16335p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D16335g PE=3 SV=1
A0A1E3PMZ5_9ASCO41.17%11950.0Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_50704 PE=3 SV=1
A0A1E4TCE2_9ASCO40.69%11230.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_137158 PE=3 SV=1
A0A1D8PIM4_CANAL35.70%12130.0Ubiquitin-specific protease OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.1777 PE=3 SV=1
UBP15_YEAST35.20%11790.0Ubiquitin carboxyl-terminal hydrolase 15 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UBP15 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0201

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 200 400 600 800 1000 1240

Detailed signature matches

  1. Domain IPR008974
    TRAF-like
    1. G3DSA:2.60.21...
    2. SSF49599 (TRAF doma...)
  2. Domain IPR002083
    MATH/TRAF domain
    1. PF00917 (MATH)
    2. PS50144 (MATH)
    3. SM00061 (math_3)
  3. Domain IPR028889
    Ubiquitin specific protease domain
    1. PS50235 (USP_3)
  4. Domain IPR001394
    Peptidase C19, ubiquitin carboxyl-terminal hydrolase
    1. PF00443 (UCH)
  5. Domain IPR024729
    Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain
    1. PF12436 (USP7_ICP0_bdg)
  6. Domain IPR029346
    Ubiquitin carboxyl-terminal hydrolase, C-terminal
    1. PF14533 (USP7_C2)
  7. SITE IPR018200
    Ubiquitin specific protease, conserved site
    1. PS00972 (USP_1)
    2. PS00973 (USP_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.90.70.10
  2. SSF54001 (Cysteine ...)
  3. cd02659 (peptidase_...)
  4. mobidb-lite (disord...)

Residue annotation

  1. Active Site cd02659

Protein sequence

>MCA_01070_1
MDMDLREDDMDDFDSQSYARQDRESTDTSQNVTPSASIEAANDVEAMKAKLLAPLDDPEMTVLEEAVFDWDIDNWRELPK
KIYSKPYSLGGYDWKFYLFPEGNNTPNVSIYLATEPTKSKKTDEEETSSETSNDNDEDSDWSVCCLFGLVMSNPNDPSIC
VSNSANHRFTNEESDWGFTSFCDLRKLFVPVDGFQRPLIENDQVKLQVYIRLINDPTGVLWHNFKNYDSKKETGYVGLKN
QGATCYLNSLLQSLYFTTAFKNSVLKIPTDGEPDGVPYALQRVFTKLHRSQNPVGTLELTKSFGWDSADAFTQHDVQELN
RVLMDNLEGKMKGTEVEGALNKIFVGQFKSYIKCVNVDYESSRIEDYWDIQLNVKGMRNVEDSFKDYIQVETLDGENQYM
LTGYGLQDAKKGVVFKSFPPVLHLQLKRYDFDPIRGDTVKINDRYEFPTEIDLSPYLDEESRNLPENKDCTYALHGVLVH
CGDLNIGHYYALLKPTKDGPWYKFDDDRVTRATMKEVLEDNFGGEHPIDPRFRPTRPNSFWKHNSAYMLVYIRKSRIDEI
LFEDTIPENILKRVEIEDREERNRQREREEQHLYMNVRCATIGKQFRNMRSFDLAVFNDNDPFQNPKEAFADVLKVRKTI
TAEGFLDLLLQSNPQIDRNTIRLWTMIHRDNRTFRLNDPIVNASVPLAKLQSKDDNGENGICLFVEELSPHFIQSCAASG
IDPYAPEVEGRGRRSLIFIKHYNIETQTLSGLMSVVVYSNDKLSTLIPQINKAMNWDDDTPLILWEEVKPYMIDRLDEDA
TFEQAELDSGDIITFEKVYPKERLEELVNAGAYENAAEYYQFLCNRVPITFKHRIEPESEKDGIVVSYKEPIPDFTVWFD
KKKDYNQMASLLAGKLGVEPTHLQFFLMGSNGNIIKGPIKRNISSLEEVLQSYKNVGHHNLGNSIVFGYDVLKMSLAEFE
TKKIIKYYWLPKEGLIHEQRHEALVAKTATIQQIVLELPEKVGISQSDLDKIKVWAVNAHTFQESLPPHYPVISLQAYNQ
LCISMMSDEEYALTTDPKMMDSIRLVEVFHFYRDPNQPHGLPFSFALKRGEKFKQTKLRLQKLLGMYDKVFERVKFVIVR
KYTPPSQIGRQNKPHIRYLDNQWTSNGLNGNGMDTIDSTDGEDAANQINISNDLNDDDEDFSVATDNIVNNSATSAPNSP
VSIDDIELFDEIEEGEVLGLDHIKRNTGRNTGERAIFIKN

GO term prediction

Biological Process

GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016579 protein deubiquitination

Molecular Function

GO:0005515 protein binding
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity

Cellular Component

None predicted.