Protein

MCA_01015_1

Length
444 amino acids

Gene name: KGD2

Description: Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

Browser: contigA:3222822-3225165-

RNA-seq: read pairs 20414, FPKM 566.8, percentile rank 94.7% (100% = highest expression)

Protein function

Annotation:KGD2Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
KEGG:K00658DLST 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61]
EGGNOG:0PHAPKGD2Dihydrolipoamide succinyltransferase
SGD closest match:S000002555KGD2Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
CGD closest match:CAL0000176210KGD2Alpha-ketoglutarate dehydrogenase

Protein alignments

%idAln lengthE-value
A0A1E4TCR4_9ASCO67.19%3848e-167Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_13891 PE=4 SV=1
ODO2_YEAST63.84%4014e-165Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KGD2 PE=1 SV=2
UniRef50_P1926263.84%4019e-162Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial n=197 Tax=cellular organisms TaxID=131567 RepID=ODO2_YEAST
MIA_01972_188.03%2348e-150MIA_01972_1
A0A0J9XGE9_GEOCN89.45%2378e-149Similar to Saccharomyces cerevisiae YDR148C KGD2 Dihydrolipoyl transsuccinylase OS=Geotrichum candidum GN=BN980_GECA13s01132g PE=4 SV=1
A0A167F2F9_9ASCO87.55%2416e-149Alpha-ketoglutarate dehydrogenase KGD2 OS=Sugiyamaella lignohabitans GN=KGD2 PE=4 SV=1
A0A1E3PIU2_9ASCO88.98%2361e-147Putative dihydrolipoamide succinyltransferase (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_24910 PE=4 SV=1
A0A060T8J2_BLAAD84.65%2411e-145ARAD1C37488p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C37488g PE=4 SV=1
Q6C5L8_YARLI83.88%2421e-144YALI0E16929p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E16929g PE=4 SV=1
A0A1D8PTH3_CANAL82.83%2339e-141Alpha-ketoglutarate dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=KGD2 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9997
Predicted cleavage: 63

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 444

Detailed signature matches

  1. Family IPR006255
    Dihydrolipoamide succinyltransferase
    1. TIGR01347
  2. Domain IPR011053
    Single hybrid motif
    1. SSF51230 (Single hy...)
  3. Domain IPR000089
    Biotin/lipoyl attachment
    1. PS50968 (BIOTINYL_L...)
    2. PF00364 (Biotin_lipoyl)
  4. Domain IPR001078
    2-oxoacid dehydrogenase acyltransferase, catalytic domain
    1. PF00198 (2-oxoacid_dh)
  5. SITE IPR003016
    2-oxo acid dehydrogenase, lipoyl-binding site
    1. PS00189 (LIPOYL)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:2.40.50...
  2. G3DSA:3.30.55...
  3. G3DSA:3.90.11...
  4. SSF52777 (CoA-depen...)
  5. cd06849 (lipoyl_domain)
  6. mobidb-lite (disord...)

Residue annotation

  1. E3 interaction sur...
  2. lipoyl attachment ...

Protein sequence

>MCA_01015_1
MLRSTAARVCVRRVAAAVSKSAPSINVLPRYISTSSSTISRSSLVRPALSQVKFSLIQSRGYAEVVNVPDMAESITEGTL
KSFEKSIGDYVEQDEEVATIETDKIDVSVNAPKAGTIVKFLAEPEDTVTVGQPLFELEPGEGGAAPAKEEAPKEEAPKKE
EAASATPKEEPKKEAAAPAAPAPAAPKKEAAPSKKETPAPAAPKVTPGVVGSREEHRVKMNRMRLRIAERLKESQNTAAS
LTTFNEVDMSSLMEMRKLYKDEVLKSKGIKFGFMGAFTKAACLAMKDIPAVNGAIENNDTIVYRDYVDVSIAVATPKGLV
TPVVRNAESLDVLGVEQAIHDLGVKARDGKLTLEDMAGGTFTISNGGVFGSLYGTPIINMPQTAVLGLHGVKERAVVVNG
QVVSRPMMYLALTYDHRLLDGREAVTFLKTVKELIEDPRKMLLL

GO term prediction

Biological Process

GO:0006099 tricarboxylic acid cycle
GO:0008152 metabolic process

Molecular Function

GO:0004149 dihydrolipoyllysine-residue succinyltransferase activity
GO:0016746 transferase activity, transferring acyl groups

Cellular Component

GO:0045252 oxoglutarate dehydrogenase complex