Protein

MCA_00998_1

Length
857 amino acids

Browser: contigA:3166197-3168855-

RNA-seq: read pairs 2963, FPKM 42.7, percentile rank 61.8% (100% = highest expression)

Protein function

KEGG:K10807RRM1 ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
EGGNOG:0PGH5FG05174.1Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
SGD closest match:S000000872RNR1Ribonucleoside-diphosphate reductase large chain 1
CGD closest match:CAL0000199428RNR1Ribonucleoside-diphosphate reductase

Protein alignments

%idAln lengthE-value
MIA_02018_185.13%8740.0MIA_02018_1
A0A0J9XCE0_GEOCN85.22%8590.0Ribonucleoside-diphosphate reductase OS=Geotrichum candidum GN=BN980_GECA09s00769g PE=3 SV=1
A0A1E3PIT4_9ASCO76.64%8820.0Ribonucleoside-diphosphate reductase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_51452 PE=3 SV=1
Q6BZQ3_YARLI75.14%8890.0Ribonucleoside-diphosphate reductase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F31735g PE=3 SV=1
A0A060T162_BLAAD77.31%8640.0Ribonucleoside-diphosphate reductase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C21780g PE=3 SV=1
A0A1E4TDZ6_9ASCO75.49%8650.0Ribonucleoside-diphosphate reductase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_26775 PE=3 SV=1
Q5A0N3_CANAL73.99%8650.0Ribonucleoside-diphosphate reductase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=RNR1 PE=3 SV=1
A0A167FQX0_9ASCO80.12%8050.0Ribonucleoside-diphosphate reductase OS=Sugiyamaella lignohabitans GN=RNR1 PE=3 SV=1
UniRef50_A0A1B7SMA073.34%8590.0Ribonucleoside-diphosphate reductase n=61 Tax=cellular organisms TaxID=131567 RepID=A0A1B7SMA0_9ASCO
RIR1_YEAST68.28%8890.0Ribonucleoside-diphosphate reductase large chain 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RNR1 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0830

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 100 200 300 400 500 600 700 800 857

Detailed signature matches

  1. Domain IPR005144
    ATP-cone domain
    1. PF03477 (ATP-cone)
    2. PS51161 (ATP_CONE)
  2. Domain IPR008926
    Ribonucleotide reductase R1 subunit, N-terminal
    1. SSF48168 (R1 subuni...)
  3. Domain IPR013509
    Ribonucleotide reductase large subunit, N-terminal
    1. PF00317 (Ribonuc_re...)
  4. Domain IPR000788
    Ribonucleotide reductase large subunit, C-terminal
    1. PF02867 (Ribonuc_re...)
    2. PR01183 (RIBORDTASEM1)
    3. PS00089 (RIBORED_LARGE)
  5. Domain IPR013346
    Ribonucleotide reductase, class I , alpha subunit
    1. TIGR02506
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.20.70.20
  2. SSF51998 (PFL-like ...)
  3. cd01679 (RNR_I)
  4. mobidb-lite (disord...)

Residue annotation

  1. active site cd01679
  2. dimer interface cd...
  3. catalytic residues...
  4. effector binding s...
  5. R2 peptide binding...

Protein sequence

>MCA_00998_1
MFVYKRDGRKEKVQFDKITARVSRLCYGLDPTHVDAVKITQRVITGVYHGVTTIELDNLAAETAAYMTTLHPDYAILAAR
IAVSNLHKQTKKQFSQVVYDLYHYVNPKNGKLSPMISDEVYNVVMKHEEELNSAIVYDRDFSYNYFGFKTLERSYLLRID
GKVAERPQHMIMRVAVGIHGDNIEKAIETYNYMSQKYFTHASPTLYNSGTPKPQMSSCFLINMKDDSIEGIYDTLKTAAL
ISKSAGGIGLSIHNIRATGSYIAGTNGTSNGIVPMLRVFNNTARYVDQGGNKRPGAFAIYLEPWHNDIFEFLDLRKNHGK
EEVRARDLFYALWISDLFMKRVEANENWTLMCPNECPGLDDVWGEEFEALYEKYEREGRGRRSVPAQKLWYAILEAQTET
GNPFMLYKDACNRKSNQQNLGTIKSSNLCCEIVEYSSPDEVAVCNLASLALPTYIERDEEGSWYDFKKLHDVTKIVVRNL
NRIIDRNYYPVPEAKRSNMRHRPIAVGVQGLADTFMSLRLPFDSAEAKQLNIEIFETIYHAAVEASIELAKEEGSYETYE
GSPASKGMLQYDLWDVTPTDLWEWDTLKADMKKYGLRNSLLVAPMPTASTSQILGFNECFEPYTSNIYSRRVLAGEFQIV
NQWLLRDLVEMGLWDETMKNRIIADNGSIQNIPNIPSDIKALYKTVWELSQKTIIDMAADRSPFIDQSQSLNIYIQSPTM
GKLTSMHFYGWKKGLKTGMYYLRTMAASAPIQFTVDQASLSHEMANKAKALDRKPYRQRVSNQNSGSSSPIQKVSESSTS
VIEDLTTKMKSTGLESSSGANDANDQSTEGKSEIDIYNEKVLACSINNPGACEMCSG

GO term prediction

Biological Process

GO:0006260 DNA replication
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005524 ATP binding

Cellular Component

None predicted.