Protein

MCA_00968_1

Length
1,249 amino acids

Gene name: ARO1A

Description: Pentafunctional AROM polypeptide

Browser: contigA:3068233-3071983+

RNA-seq: read pairs 2324, FPKM 23.0, percentile rank 45.1% (100% = highest expression)

Protein function

Annotation:ARO1APentafunctional AROM polypeptide
KEGG:K13830ARO1 pentafunctional AROM polypeptide [EC:4.2.3.4 4.2.1.10 1.1.1.25 2.7.1.71 2.5.1.19]
EGGNOG:0PKBAFG03877.1Repressor protein
SGD closest match:S000002534ARO1Pentafunctional AROM polypeptide
CGD closest match:CAL0000177892ARO1Pentafunctional AROM polypeptide

Protein alignments

%idAln lengthE-value
MIA_04961_139.09%9264e-179MIA_04961_1
A0A167DFP1_9ASCO33.81%7722e-114Pentafunctional protein ARO1p OS=Sugiyamaella lignohabitans GN=ARO1 PE=4 SV=1
UniRef50_A0A167DFP133.81%7725e-111Pentafunctional protein ARO1p n=1 Tax=Sugiyamaella lignohabitans TaxID=796027 RepID=A0A167DFP1_9ASCO
A0A060T792_BLAAD23.84%5378e-34Pentafunctional AROM polypeptide OS=Blastobotrys adeninivorans GN=ARO1 PE=3 SV=1
ARO1_CANAL23.71%4854e-33Pentafunctional AROM polypeptide OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ARO1 PE=3 SV=2
A0A0J9XAT5_GEOCN23.76%4845e-32Pentafunctional AROM polypeptide OS=Geotrichum candidum GN=ARO1 PE=3 SV=1
A0A1E4TJD1_9ASCO25.05%5191e-29Pentafunctional AROM polypeptide OS=Tortispora caseinolytica NRRL Y-17796 GN=ARO1 PE=3 SV=1
ARO1_YEAST24.95%5493e-28Pentafunctional AROM polypeptide OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ARO1 PE=1 SV=1
A0A1E3PQF0_9ASCO22.87%5291e-24Pentafunctional AROM polypeptide OS=Nadsonia fulvescens var. elongata DSM 6958 GN=ARO1 PE=3 SV=1
ARO1_YARLI22.77%5053e-18Pentafunctional AROM polypeptide OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=ARO1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1700
Predicted cleavage: 84

Protein family membership

Domains and repeats

  1. Domain
1 200 400 600 800 1000 1249

Detailed signature matches

  1. Family IPR031322
    Shikimate kinase/gluconokinase
    1. PF01202 (SKI)
  2. Family IPR001381
    3-dehydroquinate dehydratase type I
    1. PF01487 (DHquinase_I)
  3. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  4. Domain IPR013785
    Aldolase-type TIM barrel
    1. G3DSA:3.20.20.70
  5. Domain IPR013708
    Shikimate dehydrogenase substrate binding, N-terminal
    1. PF08501 (Shikimate_...)
  6. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  7. Domain IPR006151
    Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
    1. PF01488 (Shikimate_DH)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. G3DSA:3.40.50...
  3. G3DSA:3.40.50...
  4. G3DSA:3.40.50...
  5. NON_CYTOPLASM... (N...)
  6. SSF53223 (Aminoacid...)
  7. TRANSMEMBRANE (Tran...)
  8. mobidb-lite (disord...)

Protein sequence

>MCA_00968_1
MSTNHLPPIMDAQISSSSQNSPAPTPPTNPDSHKQQPSLSTQGSPNQPPSAPQNLKLPPWTNSIYSNISYSPSSTLILIG
GRGAGKSTLAVLAAIALRRRYVDVAATIASTLQTSAEEYILQHGVEKYRDLEYELLSTAIKKYPTDCVIACSSECIEGKS
SQLLLECLPKFPIIHVTRSISEVKEHLLGNKDAHIILHKTIKNLPLYRQYSNFEYTNLGTLFLDTIKPSTDFSLESSNSY
SFANFNSSSSSPSSKPPKFFTPKERISLGLRRLEQNFLYFLKYIYGEKSILRQSISKPSQSLVQSSARPEPYQQEALRRP
WKPVEEKSSPFSQTLFLPFYDIISSGIDFDRHAVGVDAVTIRIDLLASYALRMEFDPFFYISSQLIFVKNNTTLPIVYDF
DSSFFTSFRRLNNNTNSMTTENDAIAFYIEMLIFGLRLNVEYLVVYPAFIPENIFKQIINRKHFTKIISAHTVDTWDLAQ
FLQIKKEAYEKSCDIVQITNHAYSLQQNIDLMKIGTRTCTMMKHKDKNSDKHIHKKVKLSEESNNETEEPNLEEDLEESQ
IPIIAYNTGSLGRMSKSLNRLLTPVEHEAFLDNPRSFYYKSNTIKSEFAASASNARIRPNQDDDPWLVGLKGRTLETLFT
LKDRNNCIYSSGLQPKLHFYHFGNNVEKRLSHVVHQAAFDAIHLPHRYSKKWSSQIREIQPYFEQPEFGGAALSQPFKVE
SLQLCDTLSSHARFIGAINTITTTRLPGTLATASIHGDNVDWVAIHTCLSKYLRPQNIITPESRVLILGAGGFGHAAVYA
LARLGVRKFYIYNRTRENAELLVSHFQTLFSRNNIFPVDKISTNEGPRGDFATRNEEISTFLHNKRPRRLLLKSILNDEE
ESNSSCQDDATKKEDASKSSQNPESSTANKASPTLDNNNENQQSEESTTASHSTTNAIKPSSTSTKGKSAGAPPVPFKHP
FQKIYAESPEKFWAEIIENSKGKRNYGSLTFQNDSTDANKFSFTILDDVSDTPWPDPTHGPRLILQMSSNSDITLHPSFY
ESPSNPISVNGQGLSRNGVSRSSRARICLDSNYIPSQVTPFIRQALSYRQQDQNVEVIGGAELMIEQAFDHFEMLTEKRA
PKAVMVETLKKALNELDNARSLDINNNLSAFPNLESGKPRSKPANNINIDDSSSDYTDNEENLVSKLPQKPSNIKNNSLS
DILINNDQEQSNVATTSNDRPTQASIASPSSSISFTSYSSASASEIEED

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0003824 catalytic activity
GO:0003855 3-dehydroquinate dehydratase activity
GO:0004764 shikimate 3-dehydrogenase (NADP+) activity

Cellular Component

None predicted.