Protein

MCA_00943_1

Length
1,196 amino acids

Gene name: PRP22

Description: Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22; DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase

Browser: contigA:2960739-2964330+

RNA-seq: read pairs 622, FPKM 6.4, percentile rank 19.7% (100% = highest expression)

Protein function

Annotation:PRP22Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22; DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase
KEGG:K12818DHX8 ATP-dependent RNA helicase DHX8/PRP22 [EC:3.6.4.13]
EGGNOG:0PGGTPRP22ATP-dependent RNA helicase
SGD closest match:S000000815PRP22Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22
CGD closest match:CAL0000197565PRP22DEAH-box ATP-dependent RNA helicase

Protein alignments

%idAln lengthE-value
MIA_04371_180.68%9680.0MIA_04371_1
A0A060TC12_BLAAD71.06%9780.0ARAD1D32362p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D32362g PE=4 SV=1
A0A167D5Z9_9ASCO72.06%9520.0DEAH-box ATP-dependent RNA helicase PRP22 OS=Sugiyamaella lignohabitans GN=PRP22 PE=4 SV=1
A0A0J9XKT3_GEOCN76.26%9140.0Similar to Saccharomyces cerevisiae YNR011C PRP2 RNA-dependent ATPase in the DEAH-box family OS=Geotrichum candidum GN=BN980_GECA32s02001g PE=4 SV=1
UniRef50_A0A0E9NJ4170.31%9800.0Uncharacterized protein n=2 Tax=Saitoella complicata NRRL Y-17804 TaxID=698492 RepID=A0A0E9NJ41_9ASCO
Q6CF06_YARLI65.29%9710.0YALI0B11352p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B11352g PE=4 SV=1
A0A1D8PP74_CANAL58.76%9650.0DEAH-box ATP-dependent RNA helicase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PRP22 PE=4 SV=1
A0A1E4TMF7_9ASCO56.95%9710.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_43522 PE=4 SV=1
PRP22_YEAST55.94%9940.0Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRP22 PE=1 SV=1
A0A1E3PKA5_9ASCO74.13%4330.0p-loop containing nucleoside triphosphate hydrolase protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82739 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.6223

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 200 400 600 800 1000 1196

Detailed signature matches

  1. Domain IPR012340
    Nucleic acid-binding, OB-fold
    1. SSF50249 (Nucleic a...)
  2. Domain IPR022967
    RNA-binding domain, S1
    1. SM00316 (S1_6)
  3. Domain IPR003029
    S1 domain
    1. PS50126 (S1)
    2. PF00575 (S1)
  4. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  5. Domain IPR014001
    Helicase superfamily 1/2, ATP-binding domain
    1. PS51192 (HELICASE_A...)
    2. SM00487 (ultradead3)
  6. Domain IPR001650
    Helicase, C-terminal
    1. PS51194 (HELICASE_CTER)
    2. SM00490 (helicmild6)
    3. PF00271 (Helicase_C)
  7. Domain IPR007502
    Helicase-associated domain
    1. SM00847 (ha2_5)
    2. PF04408 (HA2)
  8. Domain IPR011709
    Domain of unknown function DUF1605
    1. PF07717 (OB_NTP_bind)
  9. SITE IPR002464
    DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
    1. PS00690 (DEAH_ATP_H...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.20.13...
  3. G3DSA:2.40.50...
  4. G3DSA:3.40.50...
  5. cd00046 (DEXDc)
  6. cd00079 (HELICc)
  7. cd05684 (S1_DHX8_he...)
  8. mobidb-lite (disord...)

Residue annotation

  1. RNA binding site c...
  2. ATP binding site c...
  3. putative Mg++ bind...
  4. nucleotide binding...
  5. ATP-binding site c...

Protein sequence

>MCA_00943_1
MEALEKLKIISLVSRLTKDISELVGESDKTLAEFVLQIHSSSKDVEDFKQQLKGAGADFPEDFIEKIDQTIRQLHPKYQK
KDSKKTASSESTEESTFEKEKEERSKKIRQDEKIFKGLALPDIDKETQDRNLKVGNGEDRHYESDDNRNSRAHRSRHSPP
RHRSRRSYSSDESTSPPRSRHHHSSRHSRRHSDDESDDDRGHHYRRSDSGGRRRDHRSRRYHSPESSQDLDPEPILNKIY
SGIVMNLTDFGAFVRLEGVRGKVDGLVHISAIRDGPRLEHPSEVVQRDQRVKVKVIKIENRKISLSMKAVNQDTGEDIEK
EPEQPAYLTGANRVGLNDITGSNSTPIGVQEVSRKRKKRLTSPERWEIRQLIASGALSAADYPELNEDINALNDPDDMEP
EEDIDIEVKDEEPPFLAGQTKQSLELSPVRVVKAPEGSLNKAAMSGASLARERREKKQQEAKEEAAAKRKAQTEGIDSSV
RNDQLFLDNKRRNGSGKWQDDVPEWKKVARFSKDVSYGKRTTLSIDEQRKSLPVYKFRQELIQAVKDNQILIVVGDTGSG
KTTQITQYLAEEGYARKGMIGCTQPRRVAAVSVAKRVAEEAGCKLGEEVGYTIRFEDCTSPRTKIKYMTDGMLQREALLD
PDMSQYSVIMLDEAHERTIATDVLFALLKKAAKRRPDLRLIITSATLDAQKFSDYFLKCPILSIPGRTFPVEILYTKEPE
FDYLDAALMTVMQIHLAEPPGDILVFLTGQEEIDTSCEILYERMKALGPDVPELIILPVYSALPSEMQSKIFEPAPPGSR
KVVIATNIAETSITIDGIYYVVDPGFVKINAYDPKLGMDSLVISPISQAQANQRAGRAGRTGPGKCYRLYTEEAFKTEML
PNTIPEIQRQNLSHTILMLKAMGINDLLHFEFMDPPPANTMLMALEELHSLMALDDEGLLTRLGRKMADFPMEPSLAKVL
IASVDAKCSDEMLTIVAMLSVQNVFYRPKEKQQQADQKKAKFHDPTGDHLMYLNVYQSWVRNGCSKTWCVENFIQERSMK
RAQDVRRQLVSIMDRYKHAIISCGSNTDSVRKVLCSGFFRNAARKDPQEGYKTLIENTLVYLHPSSALFGKAGEYVIYHT
LLLTTKEYMHCVTAINPKWLAEAAPTFFKIADNHRLSKRKKAEKIQPLFDRYANDPNEWRISAQRRSAKGGSSTFG

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003676 nucleic acid binding
GO:0004386 helicase activity

Cellular Component

None predicted.