Protein
MCA_00894_1
Length
522 amino acids
Gene name: PDH1
Description: Putative 2-methylcitrate dehydratase
Browser: contigA:2821081-2822650+
RNA-seq: read pairs 2412, FPKM 57.0, percentile rank 68.2% (100% = highest expression)
Protein function
| Annotation: | PDH1 | Putative 2-methylcitrate dehydratase | |
|---|---|---|---|
| KEGG: | K01720 | prpD | 2-methylcitrate dehydratase [EC:4.2.1.79] |
| EGGNOG: | 0PIWY | FG08851.1 | 2-methylcitrate dehydratase |
| SGD closest match: | S000006206 | PDH1 | Probable 2-methylcitrate dehydratase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_03229_1 | 85.25% | 522 | 0.0 | MIA_03229_1 |
| A0A1E4TGD5_9ASCO | 83.37% | 487 | 0.0 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_111182 PE=4 SV=1 |
| A0A0J9X2T1_GEOCN | 83.16% | 487 | 0.0 | Similar to Saccharomyces cerevisiae YPR002W PDH1 Mitochondrial protein that participates in respiration OS=Geotrichum candidum GN=BN980_GECA01s05125g PE=4 SV=1 |
| PRPD_YARLI | 80.04% | 486 | 0.0 | 2-methylcitrate dehydratase, mitochondrial OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=PDH1 PE=1 SV=1 |
| A0A167FYJ2_9ASCO | 82.51% | 486 | 0.0 | Pdh1p OS=Sugiyamaella lignohabitans GN=PDH1 PE=4 SV=1 |
| A0A1E3PHD6_9ASCO | 79.14% | 489 | 0.0 | 2-methylcitrate dehydratase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_52345 PE=4 SV=1 |
| A0A060T8L0_BLAAD | 80.70% | 487 | 0.0 | ARAD1D07942p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D07942g PE=4 SV=1 |
| PRPD_YEAST | 66.87% | 495 | 0.0 | Probable 2-methylcitrate dehydratase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PDH1 PE=1 SV=1 |
| UniRef50_M9LT44 | 64.68% | 487 | 0.0 | Cytochrome c oxidase, subunit Vb/COX4 n=3 Tax=Moesziomyces TaxID=63261 RepID=M9LT44_PSEA3 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.9325
Predicted cleavage: 25
Protein family membership
- MmgE/PrpD (IPR005656)
- 2-methylcitrate dehydratase PrpD (IPR012705)
Domains and repeats
None predicted.
Detailed signature matches
no IPR
Unintegrated signatures
Protein sequence
>MCA_00894_1 MLSFAKSSIRTLARPNLTPSLLRTSTPLISSKMTYSSINTDNVRPQPDKVLQDIADYIHNYKIDSPVAVETARLCLLDTL GCGLEALKYEQCANIIGPVVPGTSVENGTKVPGTNYQLDPIRGAWSIGTTIRWLDYNDCWLAAEWGHPSDNMGGILAVAD WLTRSAKAGATNIKGAKVFKVKDVLEGMIKAHEIQGCLALENSFNKVGLDHVVLVKVATTAVVSKMLGLNRDQTIDAVSQ AFVDGQSLRTYRHAPNTMSRKSWAAGDAVARAVNLALLVQRGEGGMPSVLTAPTWGFYDVLFKGQPFKFQRPYGSYVMEN VLFKISFPAEFHAQTAAEAAMTLHQTLKDKGYTADDIKSIKIRTQEAAMRIINKTGPLYNYADRDHTLQYMVAIPLIYGR LTADDYTDAVAANPKIDELRAKMELVEDPRFTEEYHAPDKRYIGNAIKIFLKDGTELDEVEVNYPIGHRKRREEGTPVLL SKFERHLNGRFGPEQVKAILEKSGKDVGELDVDEYVDLYVKN
GO term prediction
Biological Process
GO:0019629 propionate catabolic process, 2-methylcitrate cycle
Molecular Function
GO:0016829 lyase activity
GO:0047547 2-methylcitrate dehydratase activity
GO:0051537 2 iron, 2 sulfur cluster binding
Cellular Component
None predicted.