Protein

MCA_00871_1

Length
593 amino acids

Browser: contigA:2747324-2749106-

RNA-seq: read pairs 4440, FPKM 92.4, percentile rank 77.4% (100% = highest expression)

Protein function

KEGG:K01568PDC pyruvate decarboxylase [EC:4.1.1.1]
EGGNOG:0PKFIPyruvate decarboxylase
SGD closest match:S000002788ARO10Transaminated amino acid decarboxylase
CGD closest match:CAL0000201027PDC11Pyruvate decarboxylase

Protein alignments

%idAln lengthE-value
MIA_05380_168.71%5880.0MIA_05380_1
A0A0J9XDE0_GEOCN59.83%5950.0Similar to Saccharomyces cerevisiae YDR380W ARO10 Phenylpyruvate decarboxylase OS=Geotrichum candidum GN=BN980_GECA10s02628g PE=3 SV=1
UniRef50_A0A0J9XDE059.83%5950.0Similar to Saccharomyces cerevisiae YDR380W ARO10 Phenylpyruvate decarboxylase n=2 Tax=Saccharomycetales TaxID=4892 RepID=A0A0J9XDE0_GEOCN
A0A167DVI6_9ASCO53.96%6060.0Indolepyruvate decarboxylase 1 OS=Sugiyamaella lignohabitans GN=PDC1 PE=3 SV=1
A0A060T6T9_BLAAD50.93%5890.0ARAD1B14806p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B14806g PE=3 SV=1
Q6CA04_YARLI51.27%5910.0YALI0D06930p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D06930g PE=3 SV=1
A0A1E3PF60_9ASCO48.27%6070.0Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47659 PE=3 SV=1
A0A1E4TGK8_9ASCO46.86%6060.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_112006 PE=3 SV=1
ARO10_YEAST36.66%6111e-118Transaminated amino acid decarboxylase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ARO10 PE=1 SV=1
PDC1_CANAL38.28%5804e-115Pyruvate decarboxylase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PDC11 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.4241

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 100 200 300 400 500 593

Detailed signature matches

  1. Family IPR012110
    Thiamine pyrophosphate (TPP)-dependent enzyme
    1. PIRSF036565 (Pyruvt...)
  2. Domain IPR029061
    Thiamin diphosphate-binding fold
    1. SSF52518 (Thiamin d...)
  3. Domain IPR012001
    Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain
    1. PF02776 (TPP_enzyme_N)
  4. Domain IPR029035
    DHS-like NAD/FAD-binding domain
    1. SSF52467 (DHS-like ...)
    2. G3DSA:3.40.50...
  5. Domain IPR012000
    Thiamine pyrophosphate enzyme, central domain
    1. PF00205 (TPP_enzyme_M)
  6. Domain IPR011766
    Thiamine pyrophosphate enzyme, C-terminal TPP-binding
    1. PF02775 (TPP_enzyme_C)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. cd02005 (TPP_PDC_IPDC)
  3. cd07038 (TPP_PYR_PD...)

Residue annotation

  1. TPP binding site c...
  2. PYR/PP interface c...
  3. dimer interface cd...
  4. TPP-binding site c...
  5. dimer interface cd...

Protein sequence

>MCA_00871_1
MTSSESIPLGQYLVSRLAQLGIKHAFGVPGDFNLTLLDHFEASPDLKWVGFCNELNAAYAADGYARINNSIPMALVTTYG
VGELSALNGISGAFAENVPIIHIVGTTGRPIQENHLLIHHVSPVAQHDIRKSPDHKIYPKSSAPFACAQEYLWDRYESPK
QIDKAITEAWKTALPAYIYVPVDMVHQPVPKSLLDTPLDLTIKNKSFDEDKYVDEILEALYNAKSPVILADTLAERHHGR
DLVTKLVEKAKLWSYSTLLSKGLVDETSPYFVGVYNGELSHHGIPEAVHSSDLVLNIGALLSDSNTGGFSRKIKDENLII
LNPTYCTFKGKVHHDVHFLPILAKLVEKLDASKYKHEHPPKPTVIRRKNRPSKGDISLADLVEKVSSYLKEGDVIIPEVG
TVQFASPDMKFTKNNKIITQVFYSSIGFSLPAAVGAAFAQRDINPESPGRVILLEGDGSAQMTIQELGTMVRNRLDITVF
LLNNSGYSIERAIWGPEQKYNDICPDWKWTALLEAFGGKANDNCYSTKVATLPQLEKYVTEEAAKVESSVKGPKLVEVIL
HPNDYPWILDEQVKSMGSTNIAMYKEYSAKHDK

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0016831 carboxy-lyase activity
GO:0030976 thiamine pyrophosphate binding

Cellular Component

None predicted.