Protein

MCA_00869_1

Length
573 amino acids

Gene name: ADE2

Description: Phosphoribosylaminoimidazole carboxylase

Browser: contigA:2741845-2743567-

RNA-seq: read pairs 3764, FPKM 81.0, percentile rank 75.5% (100% = highest expression)

Protein function

Annotation:ADE2Phosphoribosylaminoimidazole carboxylase
KEGG:K11808ADE2 phosphoribosylaminoimidazole carboxylase [EC:4.1.1.21]
EGGNOG:0PH6HADE2phosphoribosyl-aminoimidazole carboxylase
SGD closest match:S000005654ADE2Phosphoribosylaminoimidazole carboxylase
CGD closest match:CAL0000185210ADE2Phosphoribosylaminoimidazole carboxylase

Protein alignments

%idAln lengthE-value
MIA_06069_174.17%5730.0MIA_06069_1
A0A0J9XJV8_GEOCN74.87%5730.0Similar to Saccharomyces cerevisiae YOR128C ADE2 Phosphoribosylaminoimidazole carboxylase OS=Geotrichum candidum GN=BN980_GECA20s00659g PE=3 SV=1
A0A1E3PGQ0_9ASCO70.86%5730.0Putative phosphoribosylaminoimidazole carboxylase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47592 PE=3 SV=1
A0A167DVU6_9ASCO68.70%5750.0Phosphoribosylaminoimidazole carboxylase ADE2 OS=Sugiyamaella lignohabitans GN=ADE2 PE=3 SV=1
I7IIC5_BLAAD68.11%5770.0ARAD1B15158p OS=Blastobotrys adeninivorans GN=AADE2 PE=3 SV=1
PUR6_CANAL64.00%5750.0Phosphoribosylaminoimidazole carboxylase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ADE2 PE=3 SV=2
UniRef50_O7419761.53%5770.0Phosphoribosylaminoimidazole carboxylase n=206 Tax=Fungi TaxID=4751 RepID=PUR6_CANGA
PUR6_YEAST61.28%5760.0Phosphoribosylaminoimidazole carboxylase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ADE2 PE=1 SV=1
Q6CDK7_YARLI61.85%5740.0YALI0B23188p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B23188g PE=3 SV=1
A0A1E4TBC6_9ASCO57.02%5630.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_133364 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0766
Predicted cleavage: 18

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
  4. Domain
1 100 200 300 400 500 573

Detailed signature matches

  1. Family IPR016301
    Phosphoribosylaminoimidazole carboxylase, fungi/plant
    1. PIRSF001340 (AIRC)
  2. Domain IPR016185
    Pre-ATP-grasp domain
    1. SSF52440 (PreATP-gr...)
  3. Domain IPR005875
    Phosphoribosylaminoimidazole carboxylase, ATPase subunit
    1. MF_01928 (PurK)
    2. TIGR01161
  4. Domain IPR011761
    ATP-grasp fold
    1. PS50975 (ATP_GRASP)
  5. Domain IPR003135
    ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type
    1. PF02222 (ATP-grasp)
  6. Domain IPR013815
    ATP-grasp fold, subdomain 1
    1. G3DSA:3.30.14...
  7. Domain IPR011054
    Rudiment single hybrid motif
    1. SSF51246 (Rudiment ...)
  8. Domain IPR000031
    PurE domain
    1. PF00731 (AIRC)
    2. SSF52255 (N5-CAIR m...)
    3. SM01001 (AIRC_2)
    4. G3DSA:3.40.50...
    5. TIGR01162
  9. Domain IPR033747
    Class I PurE
    1. MF_01929 (PurE_classI)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.30.47...
  2. G3DSA:3.40.50.20
  3. SSF56059 (Glutathio...)
  4. mobidb-lite (disord...)

Protein sequence

>MCA_00869_1
MDSKVLGILGGGQLGRMMVEAANRLNIKTVILDGENSPAKQINALTEHVNGSFTDAASIKKLASKCDVLTIEIEHVNANI
LEEIEAETKVKVHPSPKIIKLIQDKYLQKIHLIENKIATPEIMVVEDENQVSSLQKIGDAFGYPFMLKSRTNAYDGRGNY
VVKSKDDFETALTTLKGLPLYAEKFAEFTHELAVMIVVALDGTVYSYPTVETVQKNNICERVFAPARIQDSIKIKAQFLA
ENAVKCLQTIDGKTVTGAGIYGVEMFLLKDGSIYLNEIAPRPHNSGHYTLDGCVTSQFESHIRAVTGLPLPKNFATMTTP
STNVIMLNILGAEEANGELEYCKRSLNVPGAIIHLYGKSTRPNRKMGHINIVAPSMSQAEANLARVLGEEAQSSTSSQEQ
GPAGTSSSPLVGVIMGSDSDLPVMSVGCNILKKFGVPFEVKIVSAHRTPYRMTKYATEAASRGLKAIIAGAGGAAHLPGM
VAAMTTLPVIGVPVKGSTLDGVDSLHSIVQMPRGVPVATVAINNATNAALLAIRILGVFDPEYHNKLEDYHNSMESEVLG
KTERLESVGYEKY

GO term prediction

Biological Process

GO:0006189 'de novo' IMP biosynthetic process

Molecular Function

GO:0003824 catalytic activity
GO:0004638 phosphoribosylaminoimidazole carboxylase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding

Cellular Component

None predicted.