Protein

MCA_00855_1

Length
452 amino acids

Gene name: COQ1

Description: hexaprenyl pyrophosphate synthase, mitochondrial

Browser: contigA:2678896-2680255+

RNA-seq: read pairs 2397, FPKM 65.4, percentile rank 71.0% (100% = highest expression)

Protein function

Annotation:COQ1hexaprenyl pyrophosphate synthase, mitochondrial
KEGG:K05355hexPS hexaprenyl-diphosphate synthase [EC:2.5.1.82 2.5.1.83]
EGGNOG:0PJ43COQ1decaprenyl-diphosphate synthase subunit 1
SGD closest match:S000000207COQ1Hexaprenyl pyrophosphate synthase, mitochondrial
CGD closest match:CAL0000201233CAALFM_CR00570WATrans-hexaprenyltranstransferase

Protein alignments

%idAln lengthE-value
MIA_01481_187.56%4260.0MIA_01481_1
A0A060TD48_BLAAD70.73%4510.0ARAD1D48136p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D48136g PE=3 SV=1
A0A167CVK3_9ASCO76.56%4010.0Trans-hexaprenyltranstransferase OS=Sugiyamaella lignohabitans GN=COQ1 PE=3 SV=1
COQ1_YARLI69.91%4320.0Probable hexaprenyl pyrophosphate synthase, mitochondrial OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=COQ1 PE=3 SV=1
UniRef50_Q6CBH369.91%4320.0Probable hexaprenyl pyrophosphate synthase, mitochondrial n=26 Tax=Ascomycota TaxID=4890 RepID=COQ1_YARLI
A0A0J9X6A2_GEOCN69.77%4300.0Similar to Saccharomyces cerevisiae YBR003W COQ1 Hexaprenyl pyrophosphate synthetase OS=Geotrichum candidum GN=BN980_GECA02s09217g PE=3 SV=1
A0A1E3PNX7_9ASCO61.56%4370.0Hexaprenyl pyrophosphate synthetase mitochondrial OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81722 PE=3 SV=1
A0A1D8PRR4_CANAL51.65%4841e-158Trans-hexaprenyltranstransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_CR00570WA PE=4 SV=1
COQ1_YEAST52.76%4531e-150Hexaprenyl pyrophosphate synthase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=COQ1 PE=1 SV=1
A0A1E4TGJ9_9ASCO55.19%3952e-145Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_113203 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9464
Predicted cleavage: 48

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 452

Detailed signature matches

  1. Family IPR000092
    Polyprenyl synthetase
    1. PF00348 (polyprenyl...)
  2. Domain IPR008949
    Isoprenoid synthase domain
    1. SSF48576 (Terpenoid...)
    2. G3DSA:1.10.60...
  3. SITE IPR033749
    Polyprenyl synthetase, conserved site
    1. PS00723 (POLYPRENYL...)
    2. PS00444 (POLYPRENYL...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. SFLDS00005 (Isopren...)
  2. cd00685 (Trans_IPPS_HT)

Residue annotation

  1. substrate binding ...
  2. chain length deter...
  3. aspartate-rich reg...
  4. SFLDS00005
  5. catalytic residues...
  6. substrate-Mg2+ bin...
  7. active site lid re...
  8. aspartate-rich reg...

Protein sequence

>MCA_00855_1
MLSSKCTKIPRSSLLNSSKVYSKIISMNPFSYSIRYQSNLAQAAARIPVLEEKTDSVLSSTIRSASKIVQPKVPVDDPFS
IVSKEMSTLAKNIGKLIGSSHPTLDKVALYYFQSEGKHIRPLIVLLLSKALSEIPISERTRGSRDESDVAENSVDEPLSP
LKILHGLNPKVVLNPLSRPMDSFPSETEGILPKQRRLAEIVEMIHTASLLHDDVIDNSATRRGNPSGNIAFGNKMAILAG
DFLLGRASVAIARLRNAEVIELLSTTIANLVEGEFMQLKNTVQNTPEANRASFEYYLHKTYLKTASLMSKSCRATAVLAG
VQDDIVEACYQFGRNLGLCFQIVDDMLDYTVTEAKFGKPVGADLKLGLATAPVLYAWEKYPELGAMIQRQFNEPGDVERA
RELVSKAGGLERTRELAVQHADEALKQLSLLPPSNSKDALINLTKAMLNRKH

GO term prediction

Biological Process

GO:0008299 isoprenoid biosynthetic process

Molecular Function

None predicted.

Cellular Component

None predicted.