MCA_00837_1

Protein

Length

306 amino acids

RNA-seq: read pairs 7297, FPKM 293.7, percentile rank 91.7% (100% = highest expression)

Protein function

EGGNOG:	0PKGM	FG01940.1	BAR domain protein
SGD closest match:	S000001303	GVP36	Protein GVP36
CGD closest match:	CAL0000197945	GVP36	Gvp36p

Protein alignments

	%id	Aln length	E-value
MIA_05760_1	84.97%	306	4e-161	MIA_05760_1
A0A0J9X790_GEOCN	76.07%	305	2e-143	Similar to Saccharomyces cerevisiae YIL041W GVP36 BAR domain-containing protein that localizes to both early and late Golgi vesicles OS=Geotrichum candidum GN=BN980_GECA04s03013g PE=4 SV=1
A0A060SYW0_BLAAD	68.98%	303	7e-130	ARAD1C03982p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C03982g PE=4 SV=1
UniRef50_A0A060SYW0	68.98%	303	2e-126	ARAD1C03982p n=15 Tax=saccharomyceta TaxID=716545 RepID=A0A060SYW0_BLAAD
Q6CDU5_YARLI	65.51%	287	5e-119	YALI0B21120p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B21120g PE=4 SV=1
A0A167FN62_9ASCO	66.56%	305	1e-116	Gvp36p OS=Sugiyamaella lignohabitans GN=GVP36 PE=4 SV=1
A0A1E3PMU5_9ASCO	55.08%	305	6e-89	Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82136 PE=4 SV=1
A0A1E4TBP7_9ASCO	55.63%	284	4e-83	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_45636 PE=4 SV=1
Q5A473_CANAL	37.18%	277	3e-53	Gvp36p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GVP36 PE=4 SV=1
GVP36_YEAST	38.49%	265	2e-46	Protein GVP36 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GVP36 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.7372

Protein family membership

BAR domain-containing family (IPR018859)

Domains and repeats

Domain
17 - 289
Arfaptin homology (AH) domain/BAR domain (IPR027267)
BAR domain (IPR004148)

1 50 100 150 200 250 306

Detailed signature matches

IPR018859

BAR domain-containing family
1. PF10455 (BAR_2)
  
  22 - 288
  
  Pfam
  PF10455 (BAR_2)
IPR027267

Arfaptin homology (AH) domain/BAR domain
1. SSF103657 (BAR/IMD ...)
  
  28 - 289
  
  SUPERFAMILY
  SSF103657 (BAR/IMD domain-like)
IPR004148

BAR domain
1. SM00721 (5bar)
  
  17 - 289
  
  SMART
  SM00721 (5bar)

no IPR

Unintegrated signatures

Coil

195 - 215

COILS
Coil (Coil)

224 - 251

COILS
Coil (Coil)
G3DSA:1.20.12...

42 - 294

GENE3D
G3DSA:1.20.1270.60 (G3DSA:1.20.1270.60)
NON_CYTOPLASM... (N...)

21 - 306

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
SIGNAL_PEPTIDE (Sig...)

1 - 20

PHOBIUS
SIGNAL_PEPTIDE (Signal Peptide)
SIGNAL_PEPTID... (S...)

16 - 20

PHOBIUS
SIGNAL_PEPTIDE_C_REGION (Signal peptide C-region)
SIGNAL_PEPTID... (S...)

7 - 15

PHOBIUS
SIGNAL_PEPTIDE_H_REGION (Signal peptide H-region)
SIGNAL_PEPTID... (S...)

1 - 6

PHOBIUS
SIGNAL_PEPTIDE_N_REGION (Signal peptide N-region)
cd07600 (BAR_Gvp36)

51 - 287

CDD
cd07600 (BAR_Gvp36)

Residue annotation

dimer interface cd...

88S

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

91D

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

92L

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

97S

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

99K

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

100V

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

103L

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

104T

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

106A

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

107N

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

125G

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

126H

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

128T

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

129L

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

132A

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

133L

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

135R

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

136A

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

139A

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

158Y

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

161A

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

162E

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

250K

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

253L

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

254D

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

256P

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

259L

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

262L

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

263S

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

265L

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

266I

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

269Q

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

270L

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

273H

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

274K

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

276A

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

277V

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

280F

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

281N

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

283L

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

284L

dimer interface
88S, 91D, 92L, 97S, 99K, 100V, 103L, 104T, 106A, 107N, 125G, 126H, 128T, 129L, 132A, 133L, 135R, 136A, 139A, 158Y, 161A, 162E, 250K, 253L, 254D, 256P, 259L, 262L, 263S, 265L, 266I, 269Q, 270L, 273H, 274K, 276A, 277V, 280F, 281N, 283L, 284L
CDD
cd07600 (BAR_Gvp36)

Protein sequence

>MCA_00837_1
MENFNKGLASLTTSLQGLSSQVTPLTRRTQRLIQETLGNADEKTKLPDEYLELERRVDALKVVHQKLLSVTSQYENESYD
YPPNLKESFNDLSKTISEKVNELTQANSAAEAGHILTSAPKKTSGHKTLHHALSRAAAAGAEALNDSSDPLASALEKYSV
AESKVGDARIAQDELIVSRFNSAFATTLNTSLKFASKARANVHKARLNLDAAKAAAKSAKPERQVAARVEVEQAEDEFVA
ATEEAVSVMKNILDTPEPLRNLSDLIAAQLAYHKAAVEIFNQLLPEIDELQNEQENKYRESREGSS

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0005515 protein binding

Cellular Component

GO:0005737 cytoplasm

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Entry type

Status

Per-residue features