Protein
MCA_00810_1
Length
1,187 amino acids
Gene name: MDM1
Description: Mitochondrial distribution and morphology protein 1; homologue in Saccharomyces cerevisiae binds PtdIns-3-P tethering the ER to vacuoles at Nuclear-vacuolar junctions (NVJs); anchored in the ER membrane at nucleus-vacuole junctions and binds phosphatidylinositol 3-phosphate (PtdIns-3-P) in the vacuolar membrane via its Phox homology (PX) domain
Browser: contigA:2521504-2525068+
RNA-seq: read pairs 1025, FPKM 10.7, percentile rank 27.0% (100% = highest expression)
Protein function
| Annotation: | MDM1 | Mitochondrial distribution and morphology protein 1; homologue in Saccharomyces cerevisiae binds PtdIns-3-P tethering the ER to vacuoles at Nuclear-vacuolar junctions (NVJs); anchored in the ER membrane at nucleus-vacuole junctions and binds phosphatidylinositol 3-phosphate (PtdIns-3-P) in the vacuolar membrane via its Phox homology (PX) domain | |
|---|---|---|---|
| KEGG: | K17887 | SNX25 | sorting nexin-25 |
| EGGNOG: | 0PI8W | MDM1 | Intermediate filament protein |
| SGD closest match: | S000004572 | MDM1 | Structural protein MDM1 |
| CGD closest match: | CAL0000196366 | CAALFM_CR01720WA | Uncharacterized protein |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_02729_1 | 59.57% | 1222 | 0.0 | MIA_02729_1 |
| A0A060T0A1_BLAAD | 37.82% | 1232 | 0.0 | ARAD1C11308p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C11308g PE=4 SV=1 |
| UniRef50_A0A060T0A1 | 37.82% | 1232 | 0.0 | ARAD1C11308p n=1 Tax=Blastobotrys adeninivorans TaxID=409370 RepID=A0A060T0A1_BLAAD |
| A0A0J9X405_GEOCN | 54.05% | 655 | 0.0 | Similar to Saccharomyces cerevisiae YML104C MDM1 Intermediate filament protein OS=Geotrichum candidum GN=BN980_GECA01s06830g PE=4 SV=1 |
| A0A167ELM6_9ASCO | 38.47% | 1032 | 0.0 | Mdm1p OS=Sugiyamaella lignohabitans GN=MDM1 PE=4 SV=1 |
| Q6C375_YARLI | 43.14% | 459 | 2e-97 | YALI0F02035p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F02035g PE=4 SV=1 |
| A0A1E4TKM0_9ASCO | 27.72% | 1129 | 8e-98 | Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_19189 PE=4 SV=1 |
| A0A1E3PKX6_9ASCO | 38.13% | 514 | 2e-86 | Uncharacterized protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_9663 PE=4 SV=1 |
| A0A1D8PS24_CANAL | 35.59% | 458 | 3e-76 | Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_CR01720WA PE=4 SV=1 |
| MDM1_YEAST | 38.42% | 190 | 1e-27 | Structural protein MDM1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MDM1 PE=1 SV=3 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.7769
Predicted cleavage: 86
Protein family membership
None predicted.
Domains and repeats
-
Domain
1
200
400
600
800
1000
1187
Detailed signature matches
no IPR
Unintegrated signatures
-
CYTOPLASMIC_D... (C...)
-
-
NON_CYTOPLASM... (N...)
-
-
TRANSMEMBRANE (Tran...)
-
cd06876 (PX_MDM1p)
-
mobidb-lite (disord...)
Residue annotation
-
phosphoinositide b...
Protein sequence
>MCA_00810_1 MAAQISVFGQYISIEALLVLILSAAVFGYVVRELFFLFVVKSFYIWAGLFLAVGGFAVTAWSFPSDLPYRMRKQRKPFKQ TFRHYAFTKSDNWSAEVTALTADLSKPFSLYPESFLISGAVDRLIEYVIRDFVLSWYKSVSPDPTFPAHVENSIRLALYQ LINRAKQINWPDLIVTTMVPVFTEHFRKFTLADLAVREKSIGRNLSDGNEFQYAIALQYSQGLLHPALVPLKHYQYESYR KNWLRKLSSKLVPLLLGDTGTSNIVNNLTRDILACSLLFPILTMLSDPDYWNQLIVKTAGTTLQDRKKVEQLRQALNEHA TLGRNSKFKVPKDLSSKNALELEKPSKLVLIGSEADKKEYEKFILNIQRCNSLNEVKKLRYEISQKLQSGIKDKAYNKRL SYLRKVADKQIAYLSKNPSLLADSTEGGLLNYDPRREYTLSDVFNDPICFQSFMEFMSLNKRKMLVQFWLTMNSLRNPLG DNNDEEYDPLDTSQDDAFDPLTSSAVSVSSTETNQINKKSTEQNDEHMRNPNLGALINENDIYQIYNAYFNKKMPYISDE AQTAVQKFVESPEKTPELLMQARKALVYTQNVVYKALTEEDLVNFKKSDVFLNFLASTQKGNLQESTIDSLQMDSISDYE EPTTRPNEKDVEDFEKVFDFIMSNKVNPSNMKDMKDTGESSSHRANSASKLVDLLEEKRGKRSGPAPLFEDSEGSDLSSE SGGSDEMEFGVDDPSVLGDLHLAAPGDLGLIEAINILTKQIKDLYRQEQVLDPLLRKAELTNNVGNLRILRKSKASLERE IQRKELQRQQYIVQESDNSLYGRSNIMIRSYMTAQDSNGPFILYIIEVERYALDGSISAGWVVARRYSQFFQLHQLLQTM FPQVRKLPFPKKRVVLKFQQKSFVDARRIAFQKYLKSLLSMPDVCRSKAFRMFLSSETFSIDSVANTGKPGSSSGTSSGK LDSSAYIDDDSDSGVEDFVDVGEGNLSSDNISGTGNSFNSIGSGDGKKLEYSNLALEAEAEMSDLSNKPFIQPICDLFIQ LFGFDRGNNWVRGRAVVVVVQQILGGTIERKLREAINGSLASEQTFAESLDKILESFWPSGASFMEAQALKAANVPERTG SEKMKCKHDARVIIHALIRDACVNIVGSTSSKYAAYHLFEMFQHEKLNAHLVYSLLDILIEQLFPEI
GO term prediction
Biological Process
None predicted.
Molecular Function
GO:0035091 phosphatidylinositol binding
Cellular Component
None predicted.