Protein

MCA_00705_1

Length
307 amino acids

Gene name: CBR1

Description: NADH-cytochrome b5 reductase 1

Browser: contigA:2202496-2203635-

RNA-seq: read pairs 17579, FPKM 705.2, percentile rank 95.5% (100% = highest expression)

Protein function

Annotation:CBR1NADH-cytochrome b5 reductase 1
KEGG:K00326E1.6.2.2 cytochrome-b5 reductase [EC:1.6.2.2]
EGGNOG:0PFSQCBR1Electron donor reductase for cytochrome b5. The cytochrome b5 NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes (By similarity)
SGD closest match:S000001305CBR1NADH-cytochrome b5 reductase 1
CGD closest match:CAL0000182794CBR1NADH-cytochrome b5 reductase 1

Protein alignments

%idAln lengthE-value
MIA_00200_180.53%3036e-166MIA_00200_1
A0A0J9XAW2_GEOCN66.12%3042e-133NADH-cytochrome b5 reductase OS=Geotrichum candidum GN=BN980_GECA07s02468g PE=3 SV=1
UniRef50_A0A0J9XAW266.12%3044e-130NADH-cytochrome b5 reductase n=6 Tax=Fungi TaxID=4751 RepID=A0A0J9XAW2_GEOCN
A0A1E3PS76_9ASCO66.27%2491e-112NADH-cytochrome b5 reductase 1 (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_19834 PE=4 SV=1
NCB5R_CANAL63.60%2502e-104NADH-cytochrome b5 reductase 1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CBR1 PE=3 SV=1
A0A1E4TIF7_9ASCO55.02%3094e-101NADH-cytochrome b5 reductase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_71204 PE=3 SV=1
NCB5R_YARLI57.42%2565e-94NADH-cytochrome b5 reductase 1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=CBR1 PE=3 SV=1
A0A167FNN5_9ASCO57.20%2432e-93NADH-cytochrome b5 reductase OS=Sugiyamaella lignohabitans GN=CBR1 PE=3 SV=1
A0A060T2E0_BLAAD56.35%2521e-93NADH-cytochrome b5 reductase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C27984g PE=3 SV=1
NCB5R_YEAST51.16%2588e-82NADH-cytochrome b5 reductase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CBR1 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0634

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 307

Detailed signature matches

  1. Family IPR001834
    NADH:cytochrome b5 reductase (CBR)
    1. PR00406 (CYTB5RDTASE)
  2. Domain IPR017938
    Riboflavin synthase-like beta-barrel
    1. SSF63380 (Riboflavi...)
  3. Domain IPR017927
    Ferredoxin reductase-type FAD-binding domain
    1. PS51384 (FAD_FR)
  4. Domain IPR008333
    Oxidoreductase, FAD-binding domain
    1. PF00970 (FAD_binding_6)
  5. Domain IPR001433
    Oxidoreductase FAD/NAD(P)-binding
    1. PF00175 (NAD_binding_1)
  6. Domain IPR001709
    Flavoprotein pyridine nucleotide cytochrome reductase
    1. PR00371 (FPNCR)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. G3DSA:2.40.30.10
  3. G3DSA:3.40.50.80
  4. NON_CYTOPLASM... (N...)
  5. SSF52343 (Ferredoxi...)
  6. TMhelix
  7. TRANSMEMBRANE (Tran...)
  8. cd06183 (cyt_b5_red...)

Residue annotation

  1. FAD binding pocket...
  2. FAD binding motif ...
  3. NAD binding pocket...
  4. phosphate binding ...
  5. beta-alpha-beta st...

Protein sequence

>MCA_00705_1
MAEKSGDEILSTPLHGIYIPCALLIAGVAIIDWRFTPVAVLVAFILAAFKVWRGRPKQVIHPENYNEFPLVDKIPVSSNT
NIYKFALPRSSDRLGLPIGQHITISANIDGKEVTRSYTPISAEDEEGHFELLVKTYPNGNISKYLDNLKIYQSIKVRGPK
GKLQYKPNMVKNIGMIAGGTGIAPMLQVISAIVKEPTDLTNVTLIYANVTVDDILLKEELDELNAKYPNFKVHYVLNEAP
KDAPWDGSVGFVTEEIIKEHLPGPSPDTKIFICGPPPMVSAMKKATLNLGYEKARPVSKTEDQVFVF

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

None predicted.