Protein

MCA_00680_1

Length
346 amino acids

Gene name: PPH21

Description: Serine/threonine-protein phosphatase PP2A-1 catalytic subunit

Browser: contigA:2116960-2118455+

RNA-seq: read pairs 3826, FPKM 136.2, percentile rank 83.6% (100% = highest expression)

Protein function

Annotation:PPH21Serine/threonine-protein phosphatase PP2A-1 catalytic subunit
KEGG:K04382PPP2C serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
EGGNOG:0PG4NPPH21serine threonine-protein phosphatase
SGD closest match:S000002292PPH21Serine/threonine-protein phosphatase PP2A-1 catalytic subunit
CGD closest match:CAL0000200555PPH21Serine/threonine-protein phosphatase

Protein alignments

%idAln lengthE-value
MIA_00039_187.46%3510.0MIA_00039_1
A0A0J9XCM9_GEOCN84.24%3490.0Serine/threonine-protein phosphatase OS=Geotrichum candidum GN=BN980_GECA09s04168g PE=3 SV=1
A0A060T296_BLAAD77.05%3660.0Serine/threonine-protein phosphatase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C29480g PE=3 SV=1
A0A1E3PKM0_9ASCO77.59%3570.0Serine/threonine-protein phosphatase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82722 PE=3 SV=1
Q6CI78_YARLI79.30%3430.0Serine/threonine-protein phosphatase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A00891g PE=3 SV=1
UniRef50_Q96X2579.30%3430.0Serine/threonine-protein phosphatase n=25 Tax=Eukaryota TaxID=2759 RepID=Q96X25_YARLL
PP2A1_YEAST80.18%3280.0Serine/threonine-protein phosphatase PP2A-1 catalytic subunit OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PPH21 PE=1 SV=1
A0A1D8PJ80_CANAL73.06%3600.0Serine/threonine-protein phosphatase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PPH21 PE=3 SV=1
A0A1E4TIF4_9ASCO76.36%3130.0Serine/threonine-protein phosphatase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_96 PE=3 SV=1
A0A167E8T9_9ASCO73.48%3136e-180Serine/threonine-protein phosphatase OS=Sugiyamaella lignohabitans GN=PPH21 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0243

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 346

Detailed signature matches

  1. Domain IPR029052
    Metallo-dependent phosphatase-like
    1. SSF56300 (Metallo-d...)
    2. G3DSA:3.60.21.10
  2. Domain IPR004843
    Calcineurin-like phosphoesterase domain, ApaH type
    1. PF00149 (Metallophos)
  3. Domain IPR006186
    Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
    1. PS00125 (SER_THR_PH...)
    2. SM00156 (pp2a_7)
    3. PR00114 (STPHPHTASE)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. cd07415 (MPP_PP2A_P...)
  3. mobidb-lite (disord...)

Residue annotation

  1. heterotrimer inter...
  2. metal binding site...
  3. active site cd07415

Protein sequence

>MCA_00680_1
MDMDHDVQMEDVNDDTLGMSDEMQPDFHNLARLPQPGELPTQSLNQLDAWIETLSQCRPLTEDEVEALCNMAKDLLQFEE
NVQPVNAPVTICGDVHGQFHDLVELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVALKVRYPNRITILRGNHESRQI
TQVYGFYDECLRKYGSANVWKMFTDLFDFFPITALVENRIFCLHGGLSPNIETIDNIRDLNRFQEVPHDGPMCDLLWSDP
DERSSWGVSPRGAGFTFGQDISEQFNHTNNLSLISRAHQLIMEGYNWAHDQQVVTIFSAPNYCYRCGNQAAIMAVDEELQ
SVFLQYDPSPRPGEPSVSRKTPDYFL

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0016787 hydrolase activity

Cellular Component

None predicted.