Protein

MCA_00643_1

Length
766 amino acids

Gene name: PPZ1A

Description: Serine/threonine protein phosphatase Z

Browser: contigA:2007247-2009677-

RNA-seq: read pairs 2070, FPKM 33.3, percentile rank 55.6% (100% = highest expression)

Protein function

Annotation:PPZ1ASerine/threonine protein phosphatase Z
KEGG:K06269PPP1C serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
EGGNOG:0QDCKserine threonine-protein phosphatase
SGD closest match:S000004478PPZ1Serine/threonine-protein phosphatase PP-Z1
CGD closest match:CAL0000189734PPZ1Serine/threonine-protein phosphatase

Protein alignments

%idAln lengthE-value
MIA_01421_197.28%3310.0MIA_01421_1
A0A0J9X587_GEOCN78.11%4020.0Serine/threonine-protein phosphatase OS=Geotrichum candidum GN=BN980_GECA02s08711g PE=3 SV=1
A0A167DR91_9ASCO82.37%3290.0Serine/threonine-protein phosphatase OS=Sugiyamaella lignohabitans GN=PPZ1 PE=3 SV=1
UniRef50_A0A167DR9182.37%3290.0Serine/threonine-protein phosphatase n=47 Tax=saccharomyceta TaxID=716545 RepID=A0A167DR91_9ASCO
A0A1E3PQN6_9ASCO85.76%3090.0Serine/threonine-protein phosphatase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_21138 PE=3 SV=1
A0A060T3X7_BLAAD80.25%3240.0Serine/threonine-protein phosphatase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A12826g PE=3 SV=1
Q6C402_YARLI82.75%3130.0Serine/threonine-protein phosphatase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E30899g PE=3 SV=2
PPZ1_YEAST81.35%3110.0Serine/threonine-protein phosphatase PP-Z1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PPZ1 PE=1 SV=5
Q59U06_CANAL81.03%3110.0Serine/threonine-protein phosphatase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PPZ1 PE=3 SV=1
A0A1E4TFY2_9ASCO74.61%3230.0Serine/threonine-protein phosphatase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31508 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2515

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 766

Detailed signature matches

  1. Family IPR011159
    Phosphoprotein phosphatase PPZ/Ppq1
    1. PIRSF000909 (STPPPt...)
  2. Domain IPR029052
    Metallo-dependent phosphatase-like
    1. SSF56300 (Metallo-d...)
    2. G3DSA:3.60.21.10
  3. Domain IPR031675
    Serine-threonine protein phosphatase, N-terminal
    1. PF16891 (STPPase_N)
  4. Domain IPR004843
    Calcineurin-like phosphoesterase domain, ApaH type
    1. PF00149 (Metallophos)
  5. Domain IPR006186
    Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
    1. PS00125 (SER_THR_PH...)
    2. SM00156 (pp2a_7)
    3. PR00114 (STPHPHTASE)
Unintegrated signatures no IPR
Unintegrated signatures
  1. cd07414 (MPP_PP1_PPKL)
  2. mobidb-lite (disord...)

Residue annotation

  1. metal binding site...
  2. active site cd07414
  3. natural toxin bind...
  4. MYPT1 binding site...

Protein sequence

>MCA_00643_1
MGNSSSKPDKASRKSKSKASSSSIGGKGFQSKSEKNNSLSVPFTRSDTQSSSKSAKSSHSRLSTAESFVSAIDSPSASNP
SINPTSGNHSRSHSSTSLSNNANNTTTTTSNQLTNNNTTNNTTEEDYFTSKGSSLKTPNPYETSASNGFTVPLTPGPSIL
ATATDLSTPSGGVSTQDIDSNSAAGDRPRLHRRTYSSSSIIGGGVVNIMPSTPTISKSEDNSTASLSNDQSSNNGSKDDN
IQLNESENNEYNNQTSSVASSAIDTNSNSNSLNDDKNNASTVIENSSTSSFNDSTSTPNINGVKRSLSLTIPIPSSNSGV
GDTASTPGSTRRSSGTNTPNASNESADPFSNSFKRSGSSASITSLKIGNSIMTSNGPNSPGSQFVTPLSSPLPREGSSGN
LGGLSSSVSSNSSGRKLGLRTPSFNSSSVSSSSHGGLTLNIDEAIQRLLDAGYRGRTSKHVCLKNNEIALICQTARDIFL
SQPVVLDLSPPVKVVGDVHGQYSDLIRLFDMCGFPPAANYLFLGDYVDRGKQSLETILLLFCYKIKYPENFFLLRGNHEC
ANVTRVYGFYDECKRRTNIKTWKIFIDTFNTLPVAAIIAQKIFCVHGGLSPSLTNMNQLRSIQRPTDVPDFGLLNDILWS
DPADTENEWEDNERGVSYCFNKVAINKFLAKFGFDLVCRAHIVVEDGYEFFNERTLVTVFSAPNYCGEFDNWGAVMSVSE
DLLCSFELLKPLDSMALRQEMQKSRRERKHNALAATPLPNGGPQSF

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity
GO:0016787 hydrolase activity
GO:0048037 cofactor binding

Cellular Component

None predicted.