MCA_00592_1

Protein

Length

1,322 amino acids

Browser: contigA:1819414-1823383-

RNA-seq: read pairs 2314, FPKM 21.6, percentile rank 43.4% (100% = highest expression)

Protein function

EGGNOG:	0QEC8		Cell division control protein
SGD closest match:	S000004635	HOF1	Cytokinesis protein 2
CGD closest match:	CAL0000193415	HOF1	Formin-binding protein

Protein alignments

	%id	Aln length	E-value
MIA_00942_1	64.62%	325	1e-136	MIA_00942_1
A0A0J9X764_GEOCN	55.40%	352	2e-126	Similar to Saccharomyces cerevisiae YMR032W HOF1 Bud neck-localized, SH3 domain-containing protein required for cytokinesis OS=Geotrichum candidum GN=BN980_GECA04s02661g PE=4 SV=1
UniRef50_A0A0J9X764	55.40%	352	4e-123	Similar to Saccharomyces cerevisiae YMR032W HOF1 Bud neck-localized, SH3 domain-containing protein required for cytokinesis n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X764_GEOCN
Q6C455_YARLI	61.87%	299	2e-124	YALI0E29557p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E29557g PE=4 SV=1
A0A170QXN7_9ASCO	61.15%	296	4e-123	Formin-binding protein HOF1 OS=Sugiyamaella lignohabitans GN=HOF1 PE=4 SV=1
A0A1E3PJV2_9ASCO	57.14%	315	4e-116	Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_51010 PE=4 SV=1
A0A060T2E7_BLAAD	53.47%	303	1e-106	ARAD1A01232p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A01232g PE=4 SV=1
A0A1E4TK78_9ASCO	50.18%	279	3e-84	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30380 PE=4 SV=1
Q59UQ6_CANAL	31.99%	297	2e-38	Formin-binding protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HOF1 PE=4 SV=1
CYK2_YEAST	26.47%	238	2e-16	Cytokinesis protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HOF1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0387

Protein family membership

None predicted.

Domains and repeats

Domain
10 - 286
Arfaptin homology (AH) domain/BAR domain (IPR027267)
F-BAR domain (IPR031160)
Domain
14 - 100
FCH domain (IPR001060)
502 - 800
WD40/YVTN repeat-like-containing domain (IPR015943)
1,251 - 1,322
SH3 domain (IPR001452)

1 200 400 600 800 1000 1200 1322

Detailed signature matches

IPR027267

Arfaptin homology (AH) domain/BAR domain
1. SSF103657 (BAR/IMD ...)
  
  10 - 286
  
  SUPERFAMILY
  SSF103657 (BAR/IMD domain-like)
IPR031160

F-BAR domain
1. PS51741 (F_BAR)
  
  10 - 263
  
  PROSITE profiles
  PS51741 (F_BAR)
IPR001060

FCH domain
1. PF00611 (FCH)
  
  23 - 94
  
  Pfam
  PF00611 (FCH)
2. SM00055 (fch_2)
  
  14 - 100
  
  SMART
  SM00055 (fch_2)
IPR015943

WD40/YVTN repeat-like-containing domain
1. G3DSA:2.130.1...
  
  502 - 800
  
  GENE3D
  G3DSA:2.130.10.10 (G3DSA:2.130.10.10)
IPR001452

SH3 domain
1. PF00018 (SH3_1)
  
  1,269 - 1,315
  
  Pfam
  PF00018 (SH3_1)
2. SM00326 (SH3_2)
  
  1,266 - 1,321
  
  SMART
  SM00326 (SH3_2)
3. SSF50044 (SH3-domain)
  
  1,251 - 1,321
  
  SUPERFAMILY
  SSF50044 (SH3-domain)
4. PR00452 (SH3DOMAIN)
  
  1,310 - 1,322
  
  PRINTS
  PR00452 (SH3DOMAIN)
  
  1,297 - 1,306
  
  PRINTS
  PR00452 (SH3DOMAIN)
  
  1,266 - 1,276
  
  PRINTS
  PR00452 (SH3DOMAIN)
  
  1,280 - 1,295
  
  PRINTS
  PR00452 (SH3DOMAIN)
5. PS50002 (SH3)
  
  1,263 - 1,322
  
  PROSITE profiles
  PS50002 (SH3)

no IPR

Unintegrated signatures

Coil

1,322 - 1,322

COILS
Coil (Coil)

126 - 146

COILS
Coil (Coil)

387 - 426

COILS
Coil (Coil)

183 - 203

COILS
Coil (Coil)
G3DSA:2.30.30.40

1,126 - 1,322

GENE3D
G3DSA:2.30.30.40 (G3DSA:2.30.30.40)
G3DSA:2.40.50...

176 - 420

GENE3D
G3DSA:2.40.50.100 (G3DSA:2.40.50.100)
cd00174 (SH3)

1,267 - 1,318

CDD
cd00174 (SH3)
cd07651 (F-BAR_Pomb...)

18 - 253

CDD
cd07651 (F-BAR_PombeCdc15_like)
mobidb-lite (disord...)

839 - 944

MobiDB Lite
mobidb-lite (disorder_prediction)

357 - 393

MobiDB Lite
mobidb-lite (disorder_prediction)

430 - 750

MobiDB Lite
mobidb-lite (disorder_prediction)

972 - 1,025

MobiDB Lite
mobidb-lite (disorder_prediction)

1,087 - 1,192

MobiDB Lite
mobidb-lite (disorder_prediction)

767 - 819

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

dimer interface cd...

23G

dimer interface
23G, 26T, 33Q, 36H, 37T, 40D, 43N, 44F, 47E, 48R, 51I, 55Y, 58K, 62L, 85N, 88G, 187K, 191Q, 216Q, 220E, 223V, 226L, 227K, 230L, 234T, 237V, 241C, 245D, 248C, 249E, 252R
CDD
cd07651 (F-BAR_PombeCdc15_like)

26T

dimer interface
23G, 26T, 33Q, 36H, 37T, 40D, 43N, 44F, 47E, 48R, 51I, 55Y, 58K, 62L, 85N, 88G, 187K, 191Q, 216Q, 220E, 223V, 226L, 227K, 230L, 234T, 237V, 241C, 245D, 248C, 249E, 252R
CDD
cd07651 (F-BAR_PombeCdc15_like)

33Q

dimer interface
23G, 26T, 33Q, 36H, 37T, 40D, 43N, 44F, 47E, 48R, 51I, 55Y, 58K, 62L, 85N, 88G, 187K, 191Q, 216Q, 220E, 223V, 226L, 227K, 230L, 234T, 237V, 241C, 245D, 248C, 249E, 252R
CDD
cd07651 (F-BAR_PombeCdc15_like)

36H

dimer interface
23G, 26T, 33Q, 36H, 37T, 40D, 43N, 44F, 47E, 48R, 51I, 55Y, 58K, 62L, 85N, 88G, 187K, 191Q, 216Q, 220E, 223V, 226L, 227K, 230L, 234T, 237V, 241C, 245D, 248C, 249E, 252R
CDD
cd07651 (F-BAR_PombeCdc15_like)

37T

dimer interface
23G, 26T, 33Q, 36H, 37T, 40D, 43N, 44F, 47E, 48R, 51I, 55Y, 58K, 62L, 85N, 88G, 187K, 191Q, 216Q, 220E, 223V, 226L, 227K, 230L, 234T, 237V, 241C, 245D, 248C, 249E, 252R
CDD
cd07651 (F-BAR_PombeCdc15_like)

40D

dimer interface
23G, 26T, 33Q, 36H, 37T, 40D, 43N, 44F, 47E, 48R, 51I, 55Y, 58K, 62L, 85N, 88G, 187K, 191Q, 216Q, 220E, 223V, 226L, 227K, 230L, 234T, 237V, 241C, 245D, 248C, 249E, 252R
CDD
cd07651 (F-BAR_PombeCdc15_like)

43N

dimer interface
23G, 26T, 33Q, 36H, 37T, 40D, 43N, 44F, 47E, 48R, 51I, 55Y, 58K, 62L, 85N, 88G, 187K, 191Q, 216Q, 220E, 223V, 226L, 227K, 230L, 234T, 237V, 241C, 245D, 248C, 249E, 252R
CDD
cd07651 (F-BAR_PombeCdc15_like)

44F

dimer interface
23G, 26T, 33Q, 36H, 37T, 40D, 43N, 44F, 47E, 48R, 51I, 55Y, 58K, 62L, 85N, 88G, 187K, 191Q, 216Q, 220E, 223V, 226L, 227K, 230L, 234T, 237V, 241C, 245D, 248C, 249E, 252R
CDD
cd07651 (F-BAR_PombeCdc15_like)

47E

dimer interface
23G, 26T, 33Q, 36H, 37T, 40D, 43N, 44F, 47E, 48R, 51I, 55Y, 58K, 62L, 85N, 88G, 187K, 191Q, 216Q, 220E, 223V, 226L, 227K, 230L, 234T, 237V, 241C, 245D, 248C, 249E, 252R
CDD
cd07651 (F-BAR_PombeCdc15_like)

48R

dimer interface
23G, 26T, 33Q, 36H, 37T, 40D, 43N, 44F, 47E, 48R, 51I, 55Y, 58K, 62L, 85N, 88G, 187K, 191Q, 216Q, 220E, 223V, 226L, 227K, 230L, 234T, 237V, 241C, 245D, 248C, 249E, 252R
CDD
cd07651 (F-BAR_PombeCdc15_like)

51I

dimer interface
23G, 26T, 33Q, 36H, 37T, 40D, 43N, 44F, 47E, 48R, 51I, 55Y, 58K, 62L, 85N, 88G, 187K, 191Q, 216Q, 220E, 223V, 226L, 227K, 230L, 234T, 237V, 241C, 245D, 248C, 249E, 252R
CDD
cd07651 (F-BAR_PombeCdc15_like)

55Y

dimer interface
23G, 26T, 33Q, 36H, 37T, 40D, 43N, 44F, 47E, 48R, 51I, 55Y, 58K, 62L, 85N, 88G, 187K, 191Q, 216Q, 220E, 223V, 226L, 227K, 230L, 234T, 237V, 241C, 245D, 248C, 249E, 252R
CDD
cd07651 (F-BAR_PombeCdc15_like)

58K

dimer interface
23G, 26T, 33Q, 36H, 37T, 40D, 43N, 44F, 47E, 48R, 51I, 55Y, 58K, 62L, 85N, 88G, 187K, 191Q, 216Q, 220E, 223V, 226L, 227K, 230L, 234T, 237V, 241C, 245D, 248C, 249E, 252R
CDD
cd07651 (F-BAR_PombeCdc15_like)

62L

dimer interface
23G, 26T, 33Q, 36H, 37T, 40D, 43N, 44F, 47E, 48R, 51I, 55Y, 58K, 62L, 85N, 88G, 187K, 191Q, 216Q, 220E, 223V, 226L, 227K, 230L, 234T, 237V, 241C, 245D, 248C, 249E, 252R
CDD
cd07651 (F-BAR_PombeCdc15_like)

85N

dimer interface
23G, 26T, 33Q, 36H, 37T, 40D, 43N, 44F, 47E, 48R, 51I, 55Y, 58K, 62L, 85N, 88G, 187K, 191Q, 216Q, 220E, 223V, 226L, 227K, 230L, 234T, 237V, 241C, 245D, 248C, 249E, 252R
CDD
cd07651 (F-BAR_PombeCdc15_like)

88G

dimer interface
23G, 26T, 33Q, 36H, 37T, 40D, 43N, 44F, 47E, 48R, 51I, 55Y, 58K, 62L, 85N, 88G, 187K, 191Q, 216Q, 220E, 223V, 226L, 227K, 230L, 234T, 237V, 241C, 245D, 248C, 249E, 252R
CDD
cd07651 (F-BAR_PombeCdc15_like)

187K

dimer interface
23G, 26T, 33Q, 36H, 37T, 40D, 43N, 44F, 47E, 48R, 51I, 55Y, 58K, 62L, 85N, 88G, 187K, 191Q, 216Q, 220E, 223V, 226L, 227K, 230L, 234T, 237V, 241C, 245D, 248C, 249E, 252R
CDD
cd07651 (F-BAR_PombeCdc15_like)

191Q

dimer interface
23G, 26T, 33Q, 36H, 37T, 40D, 43N, 44F, 47E, 48R, 51I, 55Y, 58K, 62L, 85N, 88G, 187K, 191Q, 216Q, 220E, 223V, 226L, 227K, 230L, 234T, 237V, 241C, 245D, 248C, 249E, 252R
CDD
cd07651 (F-BAR_PombeCdc15_like)

216Q

dimer interface
23G, 26T, 33Q, 36H, 37T, 40D, 43N, 44F, 47E, 48R, 51I, 55Y, 58K, 62L, 85N, 88G, 187K, 191Q, 216Q, 220E, 223V, 226L, 227K, 230L, 234T, 237V, 241C, 245D, 248C, 249E, 252R
CDD
cd07651 (F-BAR_PombeCdc15_like)

220E

dimer interface
23G, 26T, 33Q, 36H, 37T, 40D, 43N, 44F, 47E, 48R, 51I, 55Y, 58K, 62L, 85N, 88G, 187K, 191Q, 216Q, 220E, 223V, 226L, 227K, 230L, 234T, 237V, 241C, 245D, 248C, 249E, 252R
CDD
cd07651 (F-BAR_PombeCdc15_like)

223V

dimer interface
23G, 26T, 33Q, 36H, 37T, 40D, 43N, 44F, 47E, 48R, 51I, 55Y, 58K, 62L, 85N, 88G, 187K, 191Q, 216Q, 220E, 223V, 226L, 227K, 230L, 234T, 237V, 241C, 245D, 248C, 249E, 252R
CDD
cd07651 (F-BAR_PombeCdc15_like)

226L

dimer interface
23G, 26T, 33Q, 36H, 37T, 40D, 43N, 44F, 47E, 48R, 51I, 55Y, 58K, 62L, 85N, 88G, 187K, 191Q, 216Q, 220E, 223V, 226L, 227K, 230L, 234T, 237V, 241C, 245D, 248C, 249E, 252R
CDD
cd07651 (F-BAR_PombeCdc15_like)

227K

dimer interface
23G, 26T, 33Q, 36H, 37T, 40D, 43N, 44F, 47E, 48R, 51I, 55Y, 58K, 62L, 85N, 88G, 187K, 191Q, 216Q, 220E, 223V, 226L, 227K, 230L, 234T, 237V, 241C, 245D, 248C, 249E, 252R
CDD
cd07651 (F-BAR_PombeCdc15_like)

230L

dimer interface
23G, 26T, 33Q, 36H, 37T, 40D, 43N, 44F, 47E, 48R, 51I, 55Y, 58K, 62L, 85N, 88G, 187K, 191Q, 216Q, 220E, 223V, 226L, 227K, 230L, 234T, 237V, 241C, 245D, 248C, 249E, 252R
CDD
cd07651 (F-BAR_PombeCdc15_like)

234T

dimer interface
23G, 26T, 33Q, 36H, 37T, 40D, 43N, 44F, 47E, 48R, 51I, 55Y, 58K, 62L, 85N, 88G, 187K, 191Q, 216Q, 220E, 223V, 226L, 227K, 230L, 234T, 237V, 241C, 245D, 248C, 249E, 252R
CDD
cd07651 (F-BAR_PombeCdc15_like)

237V

dimer interface
23G, 26T, 33Q, 36H, 37T, 40D, 43N, 44F, 47E, 48R, 51I, 55Y, 58K, 62L, 85N, 88G, 187K, 191Q, 216Q, 220E, 223V, 226L, 227K, 230L, 234T, 237V, 241C, 245D, 248C, 249E, 252R
CDD
cd07651 (F-BAR_PombeCdc15_like)

241C

dimer interface
23G, 26T, 33Q, 36H, 37T, 40D, 43N, 44F, 47E, 48R, 51I, 55Y, 58K, 62L, 85N, 88G, 187K, 191Q, 216Q, 220E, 223V, 226L, 227K, 230L, 234T, 237V, 241C, 245D, 248C, 249E, 252R
CDD
cd07651 (F-BAR_PombeCdc15_like)

245D

dimer interface
23G, 26T, 33Q, 36H, 37T, 40D, 43N, 44F, 47E, 48R, 51I, 55Y, 58K, 62L, 85N, 88G, 187K, 191Q, 216Q, 220E, 223V, 226L, 227K, 230L, 234T, 237V, 241C, 245D, 248C, 249E, 252R
CDD
cd07651 (F-BAR_PombeCdc15_like)

248C

dimer interface
23G, 26T, 33Q, 36H, 37T, 40D, 43N, 44F, 47E, 48R, 51I, 55Y, 58K, 62L, 85N, 88G, 187K, 191Q, 216Q, 220E, 223V, 226L, 227K, 230L, 234T, 237V, 241C, 245D, 248C, 249E, 252R
CDD
cd07651 (F-BAR_PombeCdc15_like)

249E

dimer interface
23G, 26T, 33Q, 36H, 37T, 40D, 43N, 44F, 47E, 48R, 51I, 55Y, 58K, 62L, 85N, 88G, 187K, 191Q, 216Q, 220E, 223V, 226L, 227K, 230L, 234T, 237V, 241C, 245D, 248C, 249E, 252R
CDD
cd07651 (F-BAR_PombeCdc15_like)

252R

dimer interface
23G, 26T, 33Q, 36H, 37T, 40D, 43N, 44F, 47E, 48R, 51I, 55Y, 58K, 62L, 85N, 88G, 187K, 191Q, 216Q, 220E, 223V, 226L, 227K, 230L, 234T, 237V, 241C, 245D, 248C, 249E, 252R
CDD
cd07651 (F-BAR_PombeCdc15_like)
peptide ligand bin...

1,272F

peptide ligand binding site
1,272F, 1,274Y, 1,277A, 1,281E, 1,299G, 1,300W, 1,315P, 1,317N, 1,318F
CDD
cd00174 (SH3)

1,274Y

peptide ligand binding site
1,272F, 1,274Y, 1,277A, 1,281E, 1,299G, 1,300W, 1,315P, 1,317N, 1,318F
CDD
cd00174 (SH3)

1,277A

peptide ligand binding site
1,272F, 1,274Y, 1,277A, 1,281E, 1,299G, 1,300W, 1,315P, 1,317N, 1,318F
CDD
cd00174 (SH3)

1,281E

peptide ligand binding site
1,272F, 1,274Y, 1,277A, 1,281E, 1,299G, 1,300W, 1,315P, 1,317N, 1,318F
CDD
cd00174 (SH3)

1,299G

peptide ligand binding site
1,272F, 1,274Y, 1,277A, 1,281E, 1,299G, 1,300W, 1,315P, 1,317N, 1,318F
CDD
cd00174 (SH3)

1,300W

peptide ligand binding site
1,272F, 1,274Y, 1,277A, 1,281E, 1,299G, 1,300W, 1,315P, 1,317N, 1,318F
CDD
cd00174 (SH3)

1,315P

peptide ligand binding site
1,272F, 1,274Y, 1,277A, 1,281E, 1,299G, 1,300W, 1,315P, 1,317N, 1,318F
CDD
cd00174 (SH3)

1,317N

peptide ligand binding site
1,272F, 1,274Y, 1,277A, 1,281E, 1,299G, 1,300W, 1,315P, 1,317N, 1,318F
CDD
cd00174 (SH3)

1,318F

peptide ligand binding site
1,272F, 1,274Y, 1,277A, 1,281E, 1,299G, 1,300W, 1,315P, 1,317N, 1,318F
CDD
cd00174 (SH3)

Protein sequence

>MCA_00592_1
MAQSGEPELYSFANNFWGKDGTGVNTLLNHINQVKHTADDIRNFYKERIAIEEEYSRKLIALSRKGLGIHEIGTLKDALE
TIRINTEGLSKNHASAAAQFRSELDEPLAAFLSGLRTRRKALQSSIEKLFKLKTQQEVNADKLREKYEFECNKINSYYAQ
QNLLMGRELEKNNQKLDKALVSIESTKRDYQNALRLLAETTERWNKEWKLACDKFQDLEEERVNFLKSNLWAYTNIVSTV
CVNDDEGCENIRVSLEKTDVFVDNDLFVKTHGSGNEIYDPPEFVNYLNGVNSDSLERKFTYANFPRISEANETPEMFDPT
ASLSASTRYAQSIQPSVANSRLSEIAETQTVVINRNTRDSIASNNNRLSNQFGNQSRAQSQAQAQAHAHAQAQAQAQQQK
LAQQQQQQQQQKLQQLKQLQQEYEDSLEGIPVLSPPTQEFPDSQRNSPVQRIMSRQTSMESNPTSISEQSDQEAESREYE
TKSPYSNVPNDDFSNKPMLVLPSDKRPGSRQQQREQQQQQQQVPDIDVQSHYDNQPSQQEEEYHQQQASAQAGPSRNNND
YYSQNQPQQQQQQFSMPVINPPEPTPTISEPAQEKQEEQPQPKKRTWASPFRRRSKKDLNKGWSANTTPTKKTTTAPVEP
LGTPRAPFSGNNNSASAPTTGTNTPTNSRSRAGSTLEGLQKPSIASFKVNNNQQQQGDARLKDSSSSSRPATVLSMGDNM
FDLGVNPSNRSPFESRSKAPSPTKSFAKDDPLVQALEQLKIAGGAMNSNNNANSANTSAFATPSGSPIKSTPGNSTFNKP
PPLMNPDLRHQRSGSALVPPQAAFTSTEMQAASAKYANQTKEMFGNDDVSRQRSSASNRYNGNNMGGGSAPPPRERRSAS
PQPGYSQQFSNSPQQGHQPQQRMQRPRTMYENDFSQSSMMHQPPGQIGNGHHRSMSANPPDERGNDRYSTASDMGAMDYN
RYGSNNNAYRNGSRGVSPNPGMNNGGYNNANNMPMNPNDLGRSASPNPMAAGGMMRSASPNPMAGGMMRSASPNPMTGGN
MMRSASPNPMAGGNMMRSASPNPMAGGMMRSASPNPMTGGNMMRSASPNPMSMQGNNMMMGNNNNGNNYRRSASPNPQPD
EFDRYGNRMMQQPSQLPPQQQQFMGHHHRNSSTGPSRSQTNNRSVSPAPYHTPQQQQQQHPRSVSPNPMMMNNNGYMRNN
SMSAPNANFMGGVNPAVNNGGYMSNNGSSTMIPQPQQPAPAVGGGMMNSNNTNLPVIAKDGRRVIKYCKASFDYRAAIAE
ELGFRKGEIMLVVDMLDDGWWEAQCLNDGRMGLVPGNFMAPL

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0005515 protein binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

MCA_00592_1

Protein function

Protein alignments

Mitochondrial localization by mitoprotII

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

Protein sequence

GO term prediction

Biological Process

Molecular Function

Cellular Component