Protein
MCA_00555_1
Length
396 amino acids
Gene name: TIF1
Description: ATP-dependent RNA helicase eIF4A
Browser: contigA:1726082-1727661+
RNA-seq: read pairs 22022, FPKM 685.4, percentile rank 95.4% (100% = highest expression)
Protein function
| Annotation: | TIF1 | ATP-dependent RNA helicase eIF4A | |
|---|---|---|---|
| KEGG: | K03257 | EIF4A | translation initiation factor 4A |
| EGGNOG: | 0PFHJ | TIF1 | ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity) |
| SGD closest match: | S000001767 | TIF1 | ATP-dependent RNA helicase eIF4A |
| CGD closest match: | CAL0000186279 | TIF1 | ATP-dependent RNA helicase eIF4A |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| A0A1E3PIG7_9ASCO | 74.81% | 389 | 0.0 | DEAD/DEAH box helicase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_51798 PE=3 SV=1 |
| MIA_00415_1 | 76.77% | 396 | 0.0 | MIA_00415_1 |
| A0A0J9X2D7_GEOCN | 76.96% | 395 | 0.0 | Similar to Saccharomyces cerevisiae YJL138C TIF2 Translation initiation factor eIF4A OS=Geotrichum candidum GN=BN980_GECA01s00527g PE=3 SV=1 |
| A0A167CZQ7_9ASCO | 74.62% | 394 | 0.0 | Translation initiation factor eIF4A OS=Sugiyamaella lignohabitans GN=TIF1 PE=3 SV=1 |
| A0A060T8H0_BLAAD | 72.84% | 394 | 0.0 | ARAD1C36916p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C36916g PE=3 SV=1 |
| UniRef50_A0A0G2G591 | 72.70% | 392 | 0.0 | Putative eukaryotic translation initiation factor n=3 Tax=Pezizomycotina TaxID=147538 RepID=A0A0G2G591_9EURO |
| IF4A_YARLI | 71.07% | 394 | 0.0 | ATP-dependent RNA helicase eIF4A OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=TIF1 PE=3 SV=1 |
| IF4A_CANAL | 66.92% | 396 | 0.0 | ATP-dependent RNA helicase eIF4A OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TIF1 PE=3 SV=1 |
| IF4A_YEAST | 67.26% | 394 | 0.0 | ATP-dependent RNA helicase eIF4A OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TIF1 PE=1 SV=3 |
| A0A1E4TK61_9ASCO | 63.01% | 392 | 6e-173 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_81606 PE=3 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0166
Protein family membership
None predicted.
Domains and repeats
-
Domain
-
Domain
1
50
100
150
200
250
300
350
396
Detailed signature matches
no IPR
Unintegrated signatures
Residue annotation
-
ATP binding site c...
-
Mg++ binding site ...
-
motif III cd00268
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nucleotide binding...
-
ATP-binding site c...
Protein sequence
>MCA_00555_1 MSSEQLKDVEAGQIETNYDEVVNSFDDLNLKPDLLRGIYAYGFESPSSIQQRAILPVIQGHDVLAQAQSGTGKTATFSIS VLQNIDLAVKQPQALILAPTRELALQIQKVVVSLGEILNISCHPCIGGTRIHDDEEALKKGVHVIVGTPGRVQDIITRNI LKTDKIKMFVLDEADEMLSRGFKAQIYDIFQLLPRQIQVVLLSATMPADVLDVTTKFMQNPVRILVKKDELTLEGIKQFY IDTDKDEYKIDVLIDLYTTISITQAVIFCNTKRRVDHVREVLEANNFTVSSLHGEMEQAQREVIMSEFRSGSTRILITTD ILARGIDVQQVSLVINYDLPVSRENYIHRIGRSGRFGRKGAAINLVTSDDYNEMREIEKFYNTQIEEMPNNIADLL
GO term prediction
Biological Process
None predicted.
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding
Cellular Component
None predicted.