Protein

MCA_00548_1

Length
522 amino acids

Gene name: IMD4

Description: Inosine-5'-monophosphate dehydrogenase

Browser: contigA:1710808-1712589+

RNA-seq: read pairs 9620, FPKM 227.3, percentile rank 89.4% (100% = highest expression)

Protein function

Annotation:IMD4Inosine-5'-monophosphate dehydrogenase
KEGG:K00088IMPDH IMP dehydrogenase [EC:1.1.1.205]
EGGNOG:0PG5ZIMD1Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
SGD closest match:S000004520IMD4Inosine-5'-monophosphate dehydrogenase 4
CGD closest match:CAL0000175344IMH3Inosine-5'-monophosphate dehydrogenase

Protein alignments

%idAln lengthE-value
MIA_03091_185.47%5230.0MIA_03091_1
A0A0J9XCQ8_GEOCN86.77%5140.0Inosine-5'-monophosphate dehydrogenase OS=Geotrichum candidum GN=BN980_GECA09s03134g PE=3 SV=1
A0A060T5N5_BLAAD81.27%5180.0Inosine-5'-monophosphate dehydrogenase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B08448g PE=3 SV=1
A0A1E3PGQ9_9ASCO79.89%5220.0Inosine-5'-monophosphate dehydrogenase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84070 PE=3 SV=1
Q6C897_YARLI80.46%5220.0Inosine-5'-monophosphate dehydrogenase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D21530g PE=3 SV=1
IMDH_CANAL73.84%5160.0Inosine-5'-monophosphate dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=IMH3 PE=1 SV=2
UniRef50_Q59Q4673.84%5160.0Inosine-5'-monophosphate dehydrogenase n=740 Tax=root TaxID=1 RepID=IMDH_CANAL
IMDH4_YEAST72.39%5180.0Inosine-5'-monophosphate dehydrogenase 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=IMD4 PE=1 SV=1
A0A1E4TKG2_9ASCO73.54%5140.0Inosine-5'-monophosphate dehydrogenase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_837 PE=3 SV=1
A0A161HF55_9ASCO83.47%3690.0IMP dehydrogenase IMD4 OS=Sugiyamaella lignohabitans GN=IMD4 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0346

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 450 522

Detailed signature matches

  1. Family IPR005990
    Inosine-5'-monophosphate dehydrogenase
    1. PIRSF000130 (IMPDH)
    2. MF_01964 (IMPDH)
    3. TIGR01302
  2. Domain IPR013785
    Aldolase-type TIM barrel
    1. G3DSA:3.20.20.70
  3. Domain IPR001093
    IMP dehydrogenase/GMP reductase
    1. cd00381 (IMPDH)
    2. PF00478 (IMPDH)
  4. Domain IPR000644
    CBS domain
    1. PS51371 (CBS)
    2. SM00116 (cbs_1)
    3. PF00571 (CBS)
  5. SITE IPR015875
    IMP dehydrogenase / GMP reductase, conserved site
    1. PS00487 (IMP_DH_GMP...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. SM01240 (IMPDH_2)
  2. SSF51412 (Inosine m...)
  3. SSF54631 (CBS-domai...)
  4. cd04602 (CBS_pair_I...)

Residue annotation

  1. active site cd00381

Protein sequence

>MCA_00548_1
MSEIQDYTKAVELLAEYETRDGLDVKTLMDSVKRGGLTYNDFLMLPGKITFASSSVSLESKITKKITLKAPLVSSPMDTV
TESDMAIHMALLGGIGIIHHNCSADEQAEMVKKVKKYENGFIQDPVCVSPTQTVGEIKKLKETLGFAGFPVTENGTMPGK
LLGIVTSRDIQFHDDNNTPISEIMTKDLVTASGPVDLHEANDILRKSKKGKLPIVDGKGNIVALLSRTDLQKNHNYPNAS
KSKDKQLLCGAAIGTRPDDRERLTKLVAAGLDVVILDSSQGNSVFQIDMIKWAKATFPDLEVIAGNVVTREQAAELIAAG
ADGLRIGMGSGSICITQEVMAVGRPQGTAVYNVTQFAKRFGVPCIADGGIQNIGHITKAIALGASTVMMGGLLAGTTESP
GAYFYKNGQRLKAYRGMGSIEAMEKQDTNDNAATSRYFSESDTVLVAQGVSGSVVDRGSITKFIPYLTAGLQHGLQDIGV
QSITELQAKVDSGDVRFEFRSPSAQLEGGVHSLHSYEKRLHN

GO term prediction

Biological Process

GO:0006164 purine nucleotide biosynthetic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity

Cellular Component

None predicted.