Protein
MCA_00528_1
Length
554 amino acids
Gene name: ERG11
Description: Lanosterol 14-alpha demethylase
Browser: contigA:1649090-1650755-
RNA-seq: read pairs 10384, FPKM 231.2, percentile rank 89.7% (100% = highest expression)
Protein function
| Annotation: | ERG11 | Lanosterol 14-alpha demethylase | |
|---|---|---|---|
| KEGG: | K05917 | CYP51 | sterol 14-demethylase [EC:1.14.13.70] |
| EGGNOG: | 0PFY8 | ERG11 | Cytochrome p450 |
| SGD closest match: | S000001049 | ERG11 | Lanosterol 14-alpha demethylase |
| CGD closest match: | CAL0000176310 | ERG11 | Lanosterol 14-alpha demethylase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_01074_1 | 77.72% | 543 | 0.0 | MIA_01074_1 |
| A0A0J9X4F9_GEOCN | 75.46% | 542 | 0.0 | Similar to Saccharomyces cerevisiae YHR007C ERG11 Lanosterol 14-alpha-demethylase OS=Geotrichum candidum GN=BN980_GECA02s09096g PE=3 SV=1 |
| A0A1E3PE20_9ASCO | 63.39% | 549 | 0.0 | Cytochrome P450 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84273 PE=3 SV=1 |
| A0A167F3R9_9ASCO | 63.73% | 499 | 0.0 | Sterol 14-demethylase OS=Sugiyamaella lignohabitans GN=ERG11 PE=3 SV=1 |
| A0A060THG7_BLAAD | 64.20% | 500 | 0.0 | ARAD1D30866p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D30866g PE=3 SV=1 |
| UniRef50_P14263 | 61.24% | 498 | 0.0 | Lanosterol 14-alpha demethylase n=759 Tax=Fungi TaxID=4751 RepID=CP51_CANTR |
| CP51_YEAST | 62.98% | 497 | 0.0 | Lanosterol 14-alpha demethylase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERG11 PE=1 SV=1 |
| CP51_CANAL | 60.36% | 502 | 0.0 | Lanosterol 14-alpha demethylase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ERG11 PE=1 SV=2 |
| Q6CFP4_YARLI | 59.53% | 509 | 0.0 | YALI0B05126p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B05126g PE=3 SV=1 |
| A0A1E4TDG4_9ASCO | 56.49% | 485 | 0.0 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_143299 PE=3 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.3647
Protein family membership
- Cytochrome P450 (IPR001128)
- Cytochrome P450, E-class, group IV (IPR002403)
Domains and repeats
None predicted.
Detailed signature matches
no IPR
Unintegrated signatures
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CYTOPLASMIC_D... (C...)
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NON_CYTOPLASM... (N...)
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TRANSMEMBRANE (Tran...)
Protein sequence
>MCA_00528_1 MGVLRSIDTTAILESVQPVKEFLLDLPLWKLIPLLSVSALALIVIVNVLSQVLFKNPNRPPLVFHLFPWIGSSVIYGMQP YEFFDKNQKKYGDVFAFVLCGRVMTVCLGPKGHEFVFNSKLQDVSAEAAYSHLTTPVFGKGVVYDCPNHRLMEQKKFAKA ALSKDAFKSYVPKIVEEVRNYFKSSPEYYNNDPSKVSGTAHTLDTQAQITIFTASRTLLGDEVREKLNTDFAGLYADLDK GFTPINFVFPNLPLPNYRRRDNAQRIISNTYMEVINKRRAENNIDPNQDLVGALMANAVYKDGVRMTDQEIANLLIGVLM GGQHTSAATSSWYLLHLGQRPELIEELYEEQVRVCGINPETKEINPITYEALQEMPLLNNTIKETLRLHAPLHSIFRKVM NPLPVPDTRYVVPKGHYVLVSPGYTMMSDKYFKNASRFEPKRWDDPEAVPENPDAKNNAAVDYGFGLVSKGVSSPYLPFG GGRHRCIGEQFAYVQLGTILSCFVREFKWVVPGGKLAEVDYESMITVPKADQAVIQWVTRNYDGKDNEKLTRSI
GO term prediction
Biological Process
GO:0055114 oxidation-reduction process
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
Cellular Component
None predicted.