Protein

MCA_00523_1

Length
490 amino acids

Gene name: ARO8

Description: Aromatic/aminoadipate aminotransferase 1

Browser: contigA:1636391-1637864+

RNA-seq: read pairs 8008, FPKM 201.5, percentile rank 88.1% (100% = highest expression)

Protein function

Annotation:ARO8Aromatic/aminoadipate aminotransferase 1
KEGG:K00838ARO8 aromatic amino acid aminotransferase I / 2-aminoadipate transaminase [EC:2.6.1.57 2.6.1.39 2.6.1.27 2.6.1.5]
EGGNOG:0PIX0FG01285.1Aromatic amino acid aminotransferase
SGD closest match:S000003170ARO8Aromatic/aminoadipate aminotransferase 1
CGD closest match:CAL0000187633ARO8Bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase

Protein alignments

%idAln lengthE-value
MIA_01079_171.75%4920.0MIA_01079_1
A0A0J9XKK7_GEOCN65.17%4910.0Similar to Saccharomyces cerevisiae YGL202W ARO8 Aromatic aminotransferase I OS=Geotrichum candidum GN=BN980_GECA27s00967g PE=4 SV=1
A0A060T163_BLAAD57.76%4900.0ARAD1C14058p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C14058g PE=4 SV=1
A0A167DEA0_9ASCO57.67%4890.0Bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase OS=Sugiyamaella lignohabitans GN=ARO8 PE=4 SV=1
Q6C551_YARLI55.60%4910.0YALI0E20977p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E20977g PE=4 SV=1
A0A1E3PI02_9ASCO54.66%4940.0PLP-dependent transferase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83148 PE=4 SV=1
UniRef50_A0A1E3PI0254.66%4943e-178PLP-dependent transferase n=3 Tax=Saccharomycetales TaxID=4892 RepID=A0A1E3PI02_9ASCO
ARO8_YEAST50.30%4952e-161Aromatic/aminoadipate aminotransferase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ARO8 PE=1 SV=1
A0A1E4THC4_9ASCO49.20%4981e-158Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_117634 PE=4 SV=1
A0A1D8PG20_CANAL49.59%4902e-155Bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ARO8 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2782

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 450 490

Detailed signature matches

  1. Domain IPR015424
    Pyridoxal phosphate-dependent transferase
    1. SSF53383 (PLP-depen...)
  2. Domain IPR004839
    Aminotransferase, class I/classII
    1. PF00155 (Aminotran_1_2)
  3. Domain IPR015421
    Pyridoxal phosphate-dependent transferase, major region, subdomain 1
    1. G3DSA:3.40.64...
  4. Domain IPR015422
    Pyridoxal phosphate-dependent transferase, subdomain 2
    1. G3DSA:3.90.11...
Unintegrated signatures no IPR
Unintegrated signatures
  1. cd00609 (AAT_like)

Residue annotation

  1. pyridoxal 5'-phosp...
  2. homodimer interfac...
  3. catalytic residue ...

Protein sequence

>MCA_00523_1
MTGPLLAKDLSHHLSEEAKSRHPSYLKVAFKHFSDPRIVSLGGGLPLPDLFPFSSIQVESLAPPFANGIDVKPQSKEEEL
VFNIAKNRADISHEADFPLETALQYGSSAGNADLINFLKEHTKTIHNPKYEDWDIVMSVGNTQAWDATLRNFTNRGDVIL
TEEFTFSSASETAHADGVKTVPVKVDLEGIIPEALEEQLSNWDTSISPLPKLLYTIPTGQNPTGGTLSTERRQAVYQIAQ
KYDFIIVEDEPYYFLQMGDYKFGENKANEVPSHEEFLKGLVSSYLSLDTDGRVIRLDSFSKVLAPGTRLGWIVAQNRFIE
RYLRQHEVTIQVASGFSQTILNGLLQRWGQAGYIDWLIQLRLNYTQKRNAALDAVEKYMPREICEWKAPSAGMFFWIQVD
ASKHPEYATKYESDPSKLEIAIYDHGIEHGILMIPGHWFVIEDLRKGVKAFSRSGRQYMYFRGTFASVKPEALDKGLKLF
EEVLRKEFQL

GO term prediction

Biological Process

GO:0009058 biosynthetic process

Molecular Function

GO:0003824 catalytic activity
GO:0030170 pyridoxal phosphate binding

Cellular Component

None predicted.