Protein

MCA_00502_1

Length
2,324 amino acids

Gene name: FAB1

Description: 1-phosphatidylinositol 3-phosphate 5-kinase FAB1

Browser: contigA:1584234-1591288+

RNA-seq: read pairs 1506, FPKM 8.0, percentile rank 22.4% (100% = highest expression)

Protein function

Annotation:FAB11-phosphatidylinositol 3-phosphate 5-kinase FAB1
KEGG:K00921PIKFYVE 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]
EGGNOG:0PG1RFAB11-phosphatidylinositol-3-phosphate 5-kinase
SGD closest match:S000001915FAB11-phosphatidylinositol 3-phosphate 5-kinase FAB1
CGD closest match:CAL0000182478FAB11-phosphatidylinositol-3-phosphate 5-kinase

Protein alignments

%idAln lengthE-value
MIA_05806_152.18%20410.0MIA_05806_1
A0A0J9XB02_GEOCN49.75%10110.0Similar to Saccharomyces cerevisiae YFR019W FAB1 1-phosphatidylinositol-3-phosphate 5-kinase OS=Geotrichum candidum GN=BN980_GECA07s05114g PE=4 SV=1
UniRef50_A0A0J9XB0249.75%10110.0Similar to Saccharomyces cerevisiae YFR019W FAB1 1-phosphatidylinositol-3-phosphate 5-kinase n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XB02_GEOCN
A0A060T310_BLAAD38.60%9690.0ARAD1C37114p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C37114g PE=4 SV=1
A0A1E3PQ88_9ASCO55.09%5990.0Uncharacterized protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_12892 PE=4 SV=1
A0A167FPC1_9ASCO39.95%8410.01-phosphatidylinositol-3-phosphate 5-kinase OS=Sugiyamaella lignohabitans GN=FAB1 PE=4 SV=1
Q6C473_YARLI38.78%8339e-175YALI0E29161p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E29161g PE=4 SV=2
A0A1E4TFU0_9ASCO67.28%3826e-167Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_108698 PE=4 SV=1
FAB1_YEAST36.92%7342e-1421-phosphatidylinositol 3-phosphate 5-kinase FAB1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FAB1 PE=1 SV=3
A0A1D8PGH4_CANAL62.96%2978e-1151-phosphatidylinositol-3-phosphate 5-kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=FAB1 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0027

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 500 1000 1500 2000 2324

Detailed signature matches

  1. Family IPR002423
    Chaperonin Cpn60/TCP-1 family
    1. PF00118 (Cpn60_TCP1)
  2. Domain IPR013083
    Zinc finger, RING/FYVE/PHD-type
    1. G3DSA:3.30.40.10
  3. Domain IPR011011
    Zinc finger, FYVE/PHD-type
    1. SSF57903 (FYVE/PHD ...)
  4. Domain IPR000306
    FYVE zinc finger
    1. SM00064 (fyve_4)
    2. PF01363 (FYVE)
  5. Domain IPR017455
    Zinc finger, FYVE-related
    1. PS50178 (ZF_FYVE)
  6. Domain IPR027409
    GroEL-like apical domain
    1. SSF52029 (GroEL api...)
    2. G3DSA:3.50.7.10
  7. Domain IPR027484
    Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain
    1. G3DSA:3.30.80...
  8. Domain IPR002498
    Phosphatidylinositol-4-phosphate 5-kinase, core
    1. SM00330 (PIPK_2)
    2. PS51455 (PIPK)
    3. PF01504 (PIP5K)
  9. Domain IPR027483
    Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
    1. G3DSA:3.30.81...
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. SSF56104 (SAICAR sy...)
  3. mobidb-lite (disord...)

Protein sequence

>MCA_00502_1
MDEFDLNNLTTFPGHPYVESAQDSTFVYNIFNKVKSITSAASNAVQSVLPVQSSSDVLAGPEHSEAVMVNSQLARPARIL
THHAPVYIPTRSNSHVLKDLKKVGQSHSRNSSLGSVKSKSSTSQSKTNNNTTTNHRVSSLSKQLKNVNTDSQSNNVKFSD
SSNILGSNSLSEATRDEFPNSSMTNLNEPSNQRNISTSSIYSSSTVPSTYEHSDSPALVNPSLILTNTEPSIALSSETRQ
DHYYKPIASSHAKPITTDATTGTGIVLRDNTLNSYDHLLSSKASLAKFQSKSTLSSAISNAKTPALPTKTANSSEPFVNP
YRSDNYRVFRPSRQPRIDRPNFQPRSATRPTYKRTISSSSYRSHGGDHIQESYHPLSAKDSNSDNESIYSTAKRYFNSRV
DRRPAPLKNGGLGKEFWMKDEFVNECFRCTAKFTTFRRKHHCRICGQIFCSKCTVIINTIIAGANHATKMRLCKKCNADI
EKFESSDEEYDRQEESGSQFGEDSILADSTSNKISSSYTHNEGFLDSPRIHHGKSNQYMSFDQNFALALEASSDESEDSE
DSIPLSSFNSNYGNSRSPSRSQGGSKRHRSGTSLSIDQANSLRIGTRKKSFTARSKPSFSAAANIPPPFFGESIFSTNNN
PTSSNTNSAAHIRLNSASITHAKEFLRQVLREQGMSNKLEKWIDALMPPLLQCASHIDLDIKLFEGSDFRSLVKLKRIPG
GKPSHSKYIDGVVFSQTLTMKSMPHHISNPRVLLARNLFEHPRFHVATIKEIEDQDRVRDRAIIKRIGELRPNVILTTGN
LSRRMIEKLNSMGIAIIANIKDSVINRISRYTQASICTYESFSDSDTKLGRCDSFDVRMYQYRDVVRKYVFLCGIPKELG
CTILIRGGDYEVLGHVKKIVQFMVYVIFNLKLETSLLREEYVDVPENDPVLKEIIEKKKQKNTHQLESNNTNTPSDDGDI
NVVEHEGKILSISPFVDYGVPYLLKVARQSEDKLVAMDKDKDSFSTKDVIINILNSIEIETKHLPGHEETVDKMADFLYR
DIYKRLYDTWSKQKRLWEVSYLRDHNMFTPEYHMQMTVLYSSVCTETATPCFGPELLTFSYYNAMKDMPLGHFIERVCMD
ANVLCSEGCGRILKHHSRSYAHGNGNITVTVSDHLSGLPGLADSIFMWSTCKKCDATTPIIPMSDDTWKYSLGKYFELSF
WSTELSFKENLCPHNIYRDHVRFFSFKNLAISFEYFEIKPFEVMMPPLRLSWQPEREMKLKVSCYSNIFESINLFYSSVM
MRLKSVKVDELVPETIEQCRAKVEELLARAKEEQNAVINDLDSIFINTDPTSYLPLNSVLRSMQMYAISWDLEFAEFENN
FFPSEKDITRLTAQHLRRIFLNEDIEEKKKAESISSAAEGSEKPADFDDLNASESLNEKDSSQLGMIEEGETPKENIPAD
LQEAADSKDLNSDDDETSKELQELNQNSESDLPSDHTDQVNQVDEANDAGQTDKGDNSEQSEPVSPIDAEETGKTSVIGI
PQPLSKLSELKSFDFGAVANSAPSGYMASRLTGTRSPSPIRKDGGISRVREVVSKIESQTGISTEDSVSPDNELNSNSNK
EENDKTATEITATTEDKASGKASSISQRKPIKIRSSNIPVLKAPERSDSLSGSPDRMMNYSKLLARYNKGIAEGGFQASG
SSLSNNLNLKSNFDKIGYMGTLGFQNRYEYDRESGSVFAKPEKRYGVSDLTRHFEQVFQEFDNNRVQKLRTLEKARYRAV
PVTTSKPIVEVYQNVNEAVEEELSQSDDSDSDDGFSSTKFRKEIKKQKTPEKPLQQKRVRSTSDTTKPTLRLIDEEEDEN
KNSQKTGKDEDSSGKADSTEVDHPNDSSSPSQNNQDVTEESPEKPSNLNDSNDCKAITDGVKDISESQEDISETAPLSDS
LTKDESKSKPDDLQIPSLQPNERLGLLQSLASFWADRSATGWKPLDYPLSHSDHLFPESDVIVREDEPSSLIAFCLSYSD
YKERLNQMRQQSDPTEDIDLHKDPNAEMERHMLKKTGTHLKYQFQERSAKISCKIFYAEQFDAIRRQCASDEAFIQSLSR
CVKWDSSGGKSGSAFLKTLDDRFVIKQLSQSELDAFIKFAPSYFGFMAQAFFHDLPTALAKIFGFYQIQMKNPITHKTMK
MDVLVMENLFYNRKTSRIFDLKGSMRNRHVQQTGRENEVLLDENMVEYIYESPLFVRNHSKTSLRLSVFNDTLFLAKMNV
MDYSLVIGIDDEKQELVVGIIDFIRTFTWDKKLESWVKERGLVGGGVKEPTVVSPRQYKFRFREAMERYVMMVPDCWHPA
QKNE

GO term prediction

Biological Process

GO:0046488 phosphatidylinositol metabolic process

Molecular Function

GO:0005524 ATP binding
GO:0016307 phosphatidylinositol phosphate kinase activity
GO:0046872 metal ion binding

Cellular Component

None predicted.