Protein

MCA_00478_1

Length
678 amino acids

Gene name: MSR1

Description: Arginyl-tRNA synthetase, mitochondrial

Browser: contigA:1503736-1505773-

RNA-seq: read pairs 5993, FPKM 109.1, percentile rank 80.3% (100% = highest expression)

Protein function

Annotation:MSR1Arginyl-tRNA synthetase, mitochondrial
KEGG:K01887RARS arginyl-tRNA synthetase [EC:6.1.1.19]
EGGNOG:0PGU2PGUG_02829Arginyl-tRNA synthetase
SGD closest match:S000002749YDR341CArginine--tRNA ligase, cytoplasmic
CGD closest match:CAL0000176283orf19.3341Arginine--tRNA ligase

Protein alignments

%idAln lengthE-value
MIA_00427_178.40%6620.0MIA_00427_1
A0A0J9XI79_GEOCN69.51%6560.0Similar to Saccharomyces cerevisiae YDR341C RRS1 Arginyl-tRNA synthetase OS=Geotrichum candidum GN=BN980_GECA18s01616g PE=3 SV=1
A0A060T6X7_BLAAD66.87%6580.0ARAD1B23122p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B23122g PE=3 SV=1
A0A1E3PLX4_9ASCO68.24%6140.0Arginyl-tRNA synthetase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45903 PE=3 SV=1
A0A161HFB0_9ASCO65.14%6570.0Arginine--tRNA ligase OS=Sugiyamaella lignohabitans GN=AWJ20_3973 PE=3 SV=1
Q6C5H6_YARLI65.98%6320.0YALI0E17985p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E17985g PE=3 SV=1
SYRC_YEAST66.12%6140.0Arginine--tRNA ligase, cytoplasmic OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YDR341C PE=1 SV=1
UniRef50_Q0550666.12%6140.0Arginine--tRNA ligase, cytoplasmic n=126 Tax=Eukaryota TaxID=2759 RepID=SYRC_YEAST
A0A1D8PCI5_CANAL59.16%6220.0Arginine--tRNA ligase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.3341 PE=3 SV=1
A0A1E4TIA1_9ASCO59.61%6190.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_33122 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.6827
Predicted cleavage: 43

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 678

Detailed signature matches

  1. Family IPR001278
    Arginine-tRNA ligase
    1. PR01038 (TRNASYNTHARG)
    2. TIGR00456
    3. MF_00123 (Arg_tRNA_...)
  2. Domain IPR005148
    Arginyl tRNA synthetase N-terminal domain
    1. G3DSA:3.30.13...
    2. PF03485 (Arg_tRNA_s...)
    3. SM01016 (Arg_tRNA_s...)
    4. SSF55190 (Arginyl-t...)
  3. Domain IPR014729
    Rossmann-like alpha/beta/alpha sandwich fold
    1. G3DSA:3.40.50...
  4. Domain IPR035684
    Arginyl-tRNA synthetase, catalytic core domain
    1. cd00671 (ArgRS_core)
    2. PF00750 (tRNA-synt_1d)
  5. Domain IPR009080
    Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
    1. G3DSA:1.10.73...
    2. SSF47323 (Anticodon...)
  6. Domain IPR008909
    DALR anticodon binding
    1. PF05746 (DALR_1)
    2. SM00836 (dalr_1_4)
  7. SITE IPR001412
    Aminoacyl-tRNA synthetase, class I, conserved site
    1. PS00178 (AA_TRNA_LI...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. SSF52374 (Nucleotid...)
  2. cd07956 (Anticodon_...)

Residue annotation

  1. active site cd00671
  2. HIGH motif cd00671
  3. KMSK motif region ...
  4. tRNA binding surfa...
  5. anticodon binding ...

Protein sequence

>MCA_00478_1
MKASTKLINTNILFPKSRFCFKTHNPLAFKLNFSSFNYHLRSNTSLHPENFTPDYRRYPRHKLKMADIEQLNTKLKNLGI
ESPVKPYPGSNPELNPFDLFRSYITQELSRVSEVEQEKIFPALEWTNTSDRGDLVLPIPRIVRGKVDHEALATEWASKFE
KGPYISEIIAKGKFLQFFFNVSLLAKITVKDVLSKKENFGKANIGAGQKVVVEFSSPNIAKPFHAGHLRSTIIGGFIANL
HEILGHEVVRINYLGDWGKQFGVLGVGFKKYGSEEALEKDPIQHLFDVYVKINKDMEEEKEKSLAEGATEAHSKTDDEAR
EFFKRMSDGDEEALNLWKKFRALSIEKYKDTYARLNIYYDSYSGESQVSEETLELVNKKLLENDLITEDKGAHIVDLKKY
NKKLGKVLVRKSDGTSLYLTRDLGTAIDRYNKYHFDKMYYVIASQQDLHTAQFFKILELMGYEWAKNLKHINFGMVQGMS
TRKGTVVFLDTILEETKNAMHDVMKKNEAKYAQVENPEEIADLVGISAVLIQDMAAKRINNYAFNWSRMLSFEGDTGPYL
QYAHSRLRSVERNATEITSDDLENADLSLLTEPAAQELIRLLAQYPDVLLNALRTMEPSTIVTYLFRLTHTVSSCYDVLW
VAGQEKNLATARLALYSSARQILNNGMKLLNLTPVDRM

GO term prediction

Biological Process

GO:0006418 tRNA aminoacylation for protein translation
GO:0006420 arginyl-tRNA aminoacylation

Molecular Function

GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004814 arginine-tRNA ligase activity
GO:0005524 ATP binding

Cellular Component

GO:0005737 cytoplasm