Protein

MCA_00473_1

Length
736 amino acids

Gene name: TAH18

Description: NADPH-dependent diflavin oxidoreductase 1; component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery

Browser: contigA:1484110-1486321-

RNA-seq: read pairs 1375, FPKM 23.1, percentile rank 45.2% (100% = highest expression)

Protein function

Annotation:TAH18NADPH-dependent diflavin oxidoreductase 1; component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery
EGGNOG:0PFF9TAH18oxidoreductase which may be involved in DNA replication (By similarity)
SGD closest match:S000006252TAH18NADPH-dependent diflavin oxidoreductase 1
CGD closest match:CAL0000175936TAH18NADPH-dependent diflavin oxidoreductase 1

Protein alignments

%idAln lengthE-value
A0A0J9X6V0_GEOCN40.62%7361e-173NADPH-dependent diflavin oxidoreductase 1 OS=Geotrichum candidum GN=TAH18 PE=3 SV=1
UniRef50_A0A0J9X6V040.62%7363e-170NADPH-dependent diflavin oxidoreductase 1 n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X6V0_GEOCN
MIA_05954_141.96%7841e-171MIA_05954_1
A0A060T714_BLAAD38.01%7346e-155NADPH-dependent diflavin oxidoreductase 1 OS=Blastobotrys adeninivorans GN=TAH18 PE=3 SV=1
A0A167F185_9ASCO36.69%7559e-144NADPH-dependent diflavin oxidoreductase 1 OS=Sugiyamaella lignohabitans GN=TAH18 PE=3 SV=1
NDOR1_YARLI33.94%7638e-124NADPH-dependent diflavin oxidoreductase 1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=TAH18 PE=3 SV=1
A0A1E3PHN8_9ASCO33.56%7454e-121NADPH-dependent diflavin oxidoreductase 1 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=TAH18 PE=3 SV=1
NDOR1_CANAL35.89%6523e-119NADPH-dependent diflavin oxidoreductase 1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TAH18 PE=3 SV=2
A0A1E4TA34_9ASCO33.20%7383e-111NADPH-dependent diflavin oxidoreductase 1 OS=Tortispora caseinolytica NRRL Y-17796 GN=TAH18 PE=3 SV=1
NDOR1_YEAST31.05%7605e-104NADPH-dependent diflavin oxidoreductase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TAH18 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0107

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 736

Detailed signature matches

  1. Family IPR001094
    Flavodoxin-like
    1. PR00369 (FLAVODOXIN)
  2. Family IPR028879
    NADPH-dependent diflavin oxidoreductase 1
    1. MF_03178 (NDOR1)
  3. Domain IPR029039
    Flavoprotein-like domain
    1. SSF52218 (Flavoprot...)
    2. G3DSA:3.40.50...
  4. Domain IPR008254
    Flavodoxin/nitric oxide synthase
    1. PS50902 (FLAVODOXIN...)
    2. PF00258 (Flavodoxin_1)
  5. Domain IPR017938
    Riboflavin synthase-like beta-barrel
    1. SSF63380 (Riboflavi...)
  6. Domain IPR017927
    Ferredoxin reductase-type FAD-binding domain
    1. PS51384 (FAD_FR)
  7. Domain IPR003097
    FAD-binding, type 1
    1. PF00667 (FAD_binding_1)
  8. Domain IPR001433
    Oxidoreductase FAD/NAD(P)-binding
    1. PF00175 (NAD_binding_1)
  9. Domain IPR001709
    Flavoprotein pyridine nucleotide cytochrome reductase
    1. PR00371 (FPNCR)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:2.40.30.10
  2. G3DSA:3.40.50.80
  3. SSF52343 (Ferredoxi...)

Protein sequence

>MCA_00473_1
MKEIVILYATETGNSQDLAQLLGLKLRRLLYISPSMISNSPADKVENAKVNVSVYSMDEYLPQISNLFNPEAVEVEGKSL
DSTASETHLFTLVSTTGQGEIPKSAQKLWKFLLRKKLPPNLFSKIKFSSFGLGDSSYPRYNWAVRKVHTRFVQLGAQESI
PRAEADEQSPDGTDRVYQEWEDMILKDISQRYLADISKLAQNDSGVGFSDEIIDNESILPPINPILINKHDKSTVIPDSK
AVALSRVEQKYSSVKFYKAKLSELGRITDGKHYQDVRHIVLSVQTDSPETEEYFKYSPGDTVSLYPSNNPDDVDILLKHL
GWADVADMPIQVTTSFVRQLYSISGLEMPESLNTTKDGYYSPNGENSPLVSPLTVRTLMTHHLDITAVPRRSFFENVYRF
SRGEPEFPAREREKLKEFTTLDGLEDLFNYANRPRRSIMETLTEFESIKIPVEYATDIFPILRPRLFSIASYPQTNTSSE
VQVELCVALVKYRTILRRIRQGVCSRWLETLSSGDSVVISLGRNHLFKAAPILKGIPNSTGAPSPLILIAAGTGVAPIRS
LMQYYFGNSSNHNNNQPPPPEIHLFLGFRHPDLDFHYHEEWKNLLEYLSREQQKQQQPKVHIYVAFSRAQTSDLVANPRI
HPTIKTKAGVHLQSLLYDAAEEMGDLILNQNAGVYMCGASGKFPRETRMTFSGIVKDYLKNSAGIANVEDETLFETQAEA
YIKQMEQSGRFVQETW

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0003958 NADPH-hemoprotein reductase activity
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity

Cellular Component

None predicted.