Protein

MCA_00462_1

Length
265 amino acids

Gene name: HIS6

Description: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Browser: contigA:1460693-1461491+

RNA-seq: read pairs 759, FPKM 35.3, percentile rank 57.3% (100% = highest expression)

Protein function

Annotation:HIS61-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
KEGG:K01814hisA phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [EC:5.3.1.16]
EGGNOG:0PGN7HIS6isomerase
SGD closest match:S000001282HIS61-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Protein alignments

%idAln lengthE-value
MIA_00650_173.58%2652e-138MIA_00650_1
A0A0J9X4G2_GEOCN70.57%2653e-1311-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase OS=Geotrichum candidum GN=BN980_GECA02s04663g PE=3 SV=1
A0A167EXU4_9ASCO68.91%2673e-1231-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase OS=Sugiyamaella lignohabitans GN=HIS6 PE=3 SV=1
A0A1E3PJB1_9ASCO64.93%2683e-1181-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82565 PE=3 SV=1
A0A060THA9_BLAAD63.40%2651e-1151-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D29040g PE=3 SV=1
A0A1E4TFL9_9ASCO61.22%2632e-1101-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_107837 PE=3 SV=1
HIS4_YARLI60.66%2722e-1091-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=HIS6 PE=3 SV=1
UniRef50_A0A1X2HY7358.58%2682e-102Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=5 Tax=cellular organisms TaxID=131567 RepID=A0A1X2HY73_9FUNG
HIS4_YEAST58.15%2707e-971-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HIS6 PE=1 SV=1
A0A1D8PMD0_CANAL55.12%2837e-931-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_C405640CA PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.5960

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 265

Detailed signature matches

  1. Family IPR011858
    Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, eukaryotic
    1. TIGR02129
  2. Family IPR006062
    Histidine biosynthesis
    1. PF00977 (His_biosynth)
  3. Domain IPR013785
    Aldolase-type TIM barrel
    1. G3DSA:3.20.20.70
  4. Domain IPR011060
    Ribulose-phosphate binding barrel
    1. SSF51366 (Ribulose-...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. cd04723 (HisA_HisF)

Residue annotation

  1. active site cd04723

Protein sequence

>MCA_00462_1
MTKFRGCIDIHNGVVKQIVGGTLDTGSLATNFVSEKPPSYYSDLYKTNDIQGTHVIKLGKGCDEAAIEALAAWPGQLQVG
GGITDENSSRWLNEYKASKVIVTSYLFPNGGELSFERLEKLFDSIGRDRNKLVIDLSCRKKIVKGENGQDKIAWFVATNR
WQTLTNVQVNKKTLDKLAEYCSEFLVHAADVEGLCRGIDEDLVKKLGEWSPIPIVYAGGAKSIDDLQLVHDLSDGKVDLT
YGSALDIFGGDKVKFQDCVNWNKTH

GO term prediction

Biological Process

GO:0000105 histidine biosynthetic process
GO:0008152 metabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0003949 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity

Cellular Component

None predicted.