Protein

MCA_00444_1

Length
1,007 amino acids

Gene name: SEN1A

Description: Helicase SEN1

Browser: contigA:1413738-1416828+

RNA-seq: read pairs 1170, FPKM 14.3, percentile rank 33.1% (100% = highest expression)

Protein function

Annotation:SEN1AHelicase SEN1
KEGG:K10706SETX senataxin [EC:3.6.4.-]
EGGNOG:0PFUUSEN1tRNA-splicing endonuclease
SGD closest match:S000004422SEN1Helicase SEN1
CGD closest match:CAL0000183795SEN1Putative DNA/RNA helicase

Protein alignments

%idAln lengthE-value
A0A167CSC4_9ASCO46.92%3413e-91Putative DNA/RNA helicase SEN1 OS=Sugiyamaella lignohabitans GN=SEN1 PE=4 SV=1
UniRef50_A0A167CSC446.92%3419e-88Putative DNA/RNA helicase SEN1 n=1 Tax=Sugiyamaella lignohabitans TaxID=796027 RepID=A0A167CSC4_9ASCO
A0A1E3PFB1_9ASCO49.51%3051e-85p-loop containing nucleoside triphosphate hydrolase protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_7636 PE=4 SV=1
A0A0J9X8S5_GEOCN44.64%3454e-84Similar to Saccharomyces cerevisiae YLR430W SEN1 Presumed helicase required for RNA polymerase II transcription termination and processing of RNAs OS=Geotrichum candidum GN=BN980_GECA06s00615g PE=4 SV=1
MIA_03901_148.42%3162e-82MIA_03901_1
A0A060TAU8_BLAAD45.67%3002e-81ARAD1D26598p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D26598g PE=4 SV=1
Q5ANG6_CANAL47.65%2982e-77Putative DNA/RNA helicase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SEN1 PE=4 SV=1
SEN1_YEAST48.15%2976e-77Helicase SEN1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SEN1 PE=1 SV=2
W0TYQ4_YARLI42.52%3012e-74YALI0A19404p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A19404g PE=4 SV=1
A0A1E4THA5_9ASCO43.79%3061e-73Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_12256 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2005

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 800 900 1007

Detailed signature matches

  1. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  2. Domain IPR014016
    UvrD-like helicase, ATP-binding domain
    1. PS51198 (UVRD_HELIC...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.40.50...
  3. PF13086 (AAA_11)
  4. PF13087 (AAA_12)
  5. cd00046 (DEXDc)
  6. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...

Protein sequence

>MCA_00444_1
MSDKKPTLYTTLLSQILKWEYLSYNEVPPLKARSISTAQKTSGIPTEPAALRENSYGNIQEIKPVFASHQEYVDTMIDLS
LIELWDSLHQSQRKGIPIPVLPINNPEINLDKSMLTASISLSSLKALAEHEENTKNVSIPDIDDLESPVHNLDVFIISRY
PDMLSKKPDHQYKSTTFSVVTGSLVDNDSDPFNPRVRVKFTLDHYSLVEFSESAQNDTKFYAIRVGSLVTFKREMEALEK
FKSFKLSSQVVKGICSHIVKPSEKEINELSESYGVTKAQAQAVAGSLSPGISLIQGPPGTGKTKTILAMINHILDKNIER
VLVCAPSNAAVDEICDRLKNGIPINNGTELYKPRIVRLGNTERINPKIHDVVLDTLICDPYNDDANKTELKIFQSSSTEH
LETDAGVRAYTRATTTPATDMSVLDTPIENSYKINDFDKQISGLESQLGKLILNSRDNSDDTNSKHDKKGSPTGKSEFDK
LFNFEFEDSCSDSEYDSDSEASSSSDDEEEEEVDPYTTDAVAATSELLDVNEHNFTPIRTQAIKKIDKRSQKYFDQCKSI
ISNAEVVLCTLSGSGSSILQKSKVKFPIVVIDEAAQSTELSSIIPFQYSCNTCVMVGDPKQLPPTVFSRVATSKLFNESL
FSRMFNNFPERHYLLDVQYRMHPTISKFPVMKFYQGKVHNAPLMKQVSHRFWHEGNFPHYTFFNVCGEEERSQKTYSYFN
KKEAEQMLWWYQDLHRTTKDKISNLPDLVGIITPYREQLFYLRRYFTAKLGKEVANRITFRTIDGFQGQEKEIIFLSCVR
GSGKTKTVGFLEDERRLNVGITRAKNSLWVFGNSEALSRKSGLWKHLIGDAKSRDLYVDLEKNKSSSSNDTTEFNIDSKA
ISKKDSKSKKKKGKKGKKTKKKEGEVQYYDQNSGTLIYNRNTITQGLTPLKHHKSKYADTVLVKKRDKKRGKKSNKQLFE
TPPQKVLDELIYKSPNPKDELSKKERTKEKRRKRREAKKLLAKIYMF

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0005524 ATP binding

Cellular Component

None predicted.