Protein

MCA_00375_1

Length
398 amino acids

Gene name: FAL1

Description: ATP-dependent RNA helicase FAL1

Browser: contigA:1168628-1170094-

RNA-seq: read pairs 1046, FPKM 32.4, percentile rank 54.8% (100% = highest expression)

Protein function

Annotation:FAL1ATP-dependent RNA helicase FAL1
KEGG:K13025EIF4A3 ATP-dependent RNA helicase [EC:3.6.4.13]
EGGNOG:0PHSAFAL1ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity)
SGD closest match:S000002428FAL1ATP-dependent RNA helicase FAL1
CGD closest match:CAL0000189056FAL1ATP-dependent RNA helicase FAL1

Protein alignments

%idAln lengthE-value
A0A0J9X9U1_GEOCN85.93%3980.0Similar to Saccharomyces cerevisiae YDR021W FAL1 Nucleolar protein required for maturation of 18S rRNA OS=Geotrichum candidum GN=BN980_GECA06s03629g PE=4 SV=1
MIA_05512_185.61%3960.0MIA_05512_1
A0A1E3PL47_9ASCO82.58%3960.0ATP-dependent RNA helicase fal1 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_51412 PE=3 SV=1
FAL1_YARLI75.63%3980.0ATP-dependent RNA helicase FAL1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=FAL1 PE=3 SV=1
A0A060TF75_BLAAD76.15%3900.0ARAD1D20790p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D20790g PE=4 SV=1
UniRef50_Q1005575.06%3930.0ATP-dependent RNA helicase fal1 n=309 Tax=Eukaryota TaxID=2759 RepID=FAL1_SCHPO
FAL1_CANAL69.17%3990.0ATP-dependent RNA helicase FAL1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=FAL1 PE=3 SV=1
FAL1_YEAST63.07%3981e-180ATP-dependent RNA helicase FAL1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FAL1 PE=1 SV=1
A0A161HXV6_9ASCO81.75%2855e-180ATP-dependent RNA helicase FAL1 OS=Sugiyamaella lignohabitans GN=FAL1 PE=4 SV=1
A0A1E4TK61_9ASCO55.47%3937e-142Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_81606 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1053

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 50 100 150 200 250 300 350 398

Detailed signature matches

  1. Domain IPR014014
    RNA helicase, DEAD-box type, Q motif
    1. PS51195 (Q_MOTIF)
  2. Domain IPR014001
    Helicase superfamily 1/2, ATP-binding domain
    1. PS51192 (HELICASE_A...)
    2. SM00487 (ultradead3)
  3. Domain IPR011545
    DEAD/DEAH box helicase domain
    1. PF00270 (DEAD)
  4. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  5. Domain IPR001650
    Helicase, C-terminal
    1. PS51194 (HELICASE_CTER)
    2. SM00490 (helicmild6)
    3. PF00271 (Helicase_C)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.40.50...
  3. cd00079 (HELICc)
  4. cd00268 (DEADc)

Residue annotation

  1. ATP binding site c...
  2. Mg++ binding site ...
  3. motif III cd00268
  4. nucleotide binding...
  5. ATP-binding site c...

Protein sequence

>MCA_00375_1
MSGFDRDADEQLEFTTSSKDIEVAPTFEAMKLKESLLQGIYAYGFETPSAIQSRAISQIIYGHDTIAQAQSGTGKTATFA
IAMLEVIDTKVRSPQAIVLSPTRELAVQIQNVIMALGDYMNVQCHACIGGKSIGDDIKKFEYGQHIVSGTPGRVADMIRR
QYLDVRNISMLVLDEADTLLEKGLQEQIYEIYRYLPRAPQVVVVSATLPHDVLALTKKFMTNPTRILVKRDELTLEGLKQ
FFIAVEKEDWKFDTLCDLYDTLTITQAVIFCNTKAKVDWLAEKMKEANFAVVSMHGSMTQDERDKIMTEFRQGESRVLIS
TDIWARGIDVQQVSLVINYDIPLNRENYIHRIGRSGRFGRKGVAINFVADEEVNLLHDIEQYYSTQIDEMPININEMI

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003676 nucleic acid binding
GO:0005524 ATP binding

Cellular Component

None predicted.