Protein

MCA_00370_1

Length
316 amino acids


Gene name: ADE1

Description: Phosphoribosylaminoimidazole-succinocarboxamide synthase

Browser: contigA:1159207-1160158+

RNA-seq: read pairs 4682, FPKM 182.5, percentile rank 87.0% (100% = highest expression)

Protein function

Annotation:ADE1Phosphoribosylaminoimidazole-succinocarboxamide synthase
KEGG:K01923purC phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:6.3.2.6]
EGGNOG:0PFD3ADE1phosphoribosyl-aminoimidazole-succinocarboxamide synthase
SGD closest match:S000000070ADE1Phosphoribosylaminoimidazole-succinocarboxamide synthase
CGD closest match:CAL0000196632ADE1Phosphoribosylaminoimidazolesuccinocarboxamide synthase

Protein alignments

%idAln lengthE-value
MIA_01434_185.76%3160.0MIA_01434_1
A0A0J9X3U5_GEOCN77.00%3133e-173Similar to Saccharomyces cerevisiae YAR015W ADE1 N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase OS=Geotrichum candidum GN=BN980_GECA02s00868g PE=3 SV=1
A0A1E3PRE7_9ASCO68.57%3152e-157Phosphoribosylaminoimidazole-succinocarboxamide synthase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45523 PE=3 SV=1
A0A060TER6_BLAAD64.74%3126e-147ARAD1D09988p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D09988g PE=3 SV=1
A0A167C219_9ASCO65.92%3141e-144Phosphoribosylaminoimidazolesuccinocarboxamide synthase OS=Sugiyamaella lignohabitans GN=ADE1 PE=3 SV=1
PUR7_YEAST65.08%3151e-143Phosphoribosylaminoimidazole-succinocarboxamide synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ADE1 PE=1 SV=2
UniRef50_P2761665.08%3152e-140Phosphoribosylaminoimidazole-succinocarboxamide synthase n=237 Tax=Fungi TaxID=4751 RepID=PUR7_YEAST
A0A1E4TF08_9ASCO65.52%3191e-141Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_105199 PE=3 SV=1
Q6C3Q2_YARLI63.23%3102e-138YALI0E33033p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E33033g PE=3 SV=1
A0A1D8PRQ1_CANAL61.54%3121e-123Phosphoribosylaminoimidazolesuccinocarboxamide synthase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ADE1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0579

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 316

Detailed signature matches

    1. MF_00137 (SAICAR_synth)
    2. PF01259 (SAICAR_synt)
    1. PS01057 (SAICAR_SYN...)
    2. PS01058 (SAICAR_SYN...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. SSF56104 (SAICAR sy...)
  2. cd01414 (SAICAR_syn...)

Residue annotation

  1. ATP binding site c...
  2. active site cd01414
  3. substrate binding ...

Protein sequence

>MCA_00370_1
MSAVTSTDLKGALPLLAQGKVRDIYTVDESSLLFVATDRISAYDVIMENGIPDKGKLLTKISEFWFKLLGDEVKTHLVGP
KFEEDDEALFKLLPASLSEDASIKSQLIGRSLLVNKFKLIPLEVIVRGYITGSAWSEYKKSGTVHGIKVAEGLQESQEFE
TPLYTPSTKAEQGEHDENIHPSKAVEILGGDEKLAKEIEDLAIRLYTKARDYAKEKGIIIADTKFEFGYIENDDGSKTLV
LVDEVLTPDSSRFWRADTYKIGQGQDSYDKQFLRNWLTDNKLKGKEGVKIPQEIVENTRKKYIEAYEAITGEKYSS

GO term prediction

Biological Process

GO:0006164 purine nucleotide biosynthetic process

Molecular Function

GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity

Cellular Component

None predicted.