Protein
MCA_00338_1
Length
1,191 amino acids
Gene name: STE23
Description: Metalloprotease; involved in N-terminal processing of pro-a-factor to mature form
Browser: contigA:1044484-1048248+
RNA-seq: read pairs 3761, FPKM 39.0, percentile rank 59.8% (100% = highest expression)
Protein function
| Annotation: | STE23 | Metalloprotease; involved in N-terminal processing of pro-a-factor to mature form | |
|---|---|---|---|
| KEGG: | K01408 | IDE | insulysin [EC:3.4.24.56] |
| EGGNOG: | 0PIQE | IDE1 | A-pheromone processing metallopeptidase Ste23 |
| SGD closest match: | S000004381 | STE23 | A-factor-processing enzyme |
| CGD closest match: | CAL0000182147 | STE23 | Metalloendopeptidase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_00031_1 | 55.90% | 1043 | 0.0 | MIA_00031_1 |
| A0A0J9X9F8_GEOCN | 48.60% | 1035 | 0.0 | Similar to Saccharomyces cerevisiae YLR389C STE23 Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form OS=Geotrichum candidum GN=BN980_GECA06s01286g PE=3 SV=1 |
| UniRef50_A0A0J9X9F8 | 48.60% | 1035 | 0.0 | Similar to Saccharomyces cerevisiae YLR389C STE23 Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X9F8_GEOCN |
| A0A167D6Z0_9ASCO | 48.56% | 1042 | 0.0 | Ste23p OS=Sugiyamaella lignohabitans GN=STE23 PE=3 SV=1 |
| A0A1E3PF01_9ASCO | 44.52% | 1040 | 0.0 | Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_28003 PE=3 SV=1 |
| Q6C0F8_YARLI | 45.91% | 904 | 0.0 | YALI0F25091p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F25091g PE=3 SV=1 |
| A0A060T1A7_BLAAD | 42.96% | 1080 | 0.0 | ARAD1C18700p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C18700g PE=3 SV=1 |
| A0A1E4TLK1_9ASCO | 46.66% | 913 | 0.0 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_56288 PE=3 SV=1 |
| A0A1D8PQ06_CANAL | 43.87% | 962 | 0.0 | Metalloendopeptidase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=STE23 PE=4 SV=1 |
| STE23_YEAST | 41.36% | 909 | 0.0 | A-factor-processing enzyme OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=STE23 PE=1 SV=2 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.9340
Predicted cleavage: 136
Protein family membership
None predicted.
Domains and repeats
-
Domain
-
Domain
1
200
400
600
800
1000
1191
Detailed signature matches
no IPR
Unintegrated signatures
-
CYTOPLASMIC_D... (C...)
-
-
NON_CYTOPLASM... (N...)
-
TRANSMEMBRANE (Tran...)
Protein sequence
>MCA_00338_1 MKIIPRRVSSFKYPAQSPRSSLDCLFRTSSAVLVLRFIIILTASCSYSTALSSNNTLPANVSSNTLLTLNNSNNQISRKV LSFNSSSLKPQFLSFSHNYTSLISHFKRSFNSSFYNNYVQHPYLFFNPFNSFRSYSNMSSTQASSVAKSDYSSKIVKSFT VSEKPLLDNREYCVITLENGIEALLIHDPDTDKSAASLDVRVGSYADPVGIEGLAHFCEHLLFMGTEAFPKENEYSQYLS AHSGHSNAYTASEHTNYYFDVNNDSLKGALEIFSKFFICPLFSPACKDREIRAVDSENKNNLQNDDWRLSQIERTYSNPK HPKTKFSTGNIQTLDTIPTSKNIDVRERLLEFYDTHYSANLMRLCIIGTESIDTLKSWAAEYFSPIVNKNFTPPVYDSLA LSPAEAQQIIFVKPVKNMKMLKLIFSVPDQTDFYDSKPFSYASSTIGHEGPGSILYHLKEKGWAVGLSAGILHVSKGQDQ MQIKVDLTETGLKEYRKVIAIIFEYIHILRTSPINERIFYEEKVMSEISFKYRNKKDAMKTVGQYSADLQKDNLPREHLL SSSVFRKFDEEKTRDFLTYLRPDNCQITLVGKDLEGLDRKEKWYGTEHKVEPFDKELIESITNPKPNSALFLPEKNEFIP DNFDVEKKEVETPLKHPYLIRNQPNIRIWYKKDDTFWTPKAEVTIYFQSPIVSNSPSTTVKTALFLNLFEDSLNSMGYYA EVAGLRYSVSSTRDGFAVSVGGFNNKLGKLLERILSKLKGFEPTEAKFNVWKERFAQSYSNVGMGALYAQSSYHLNYLIS ENLFPLEEREQALADTTYEDVKTFGPLIYQQMGIEVVAFGNLYKQEVLDIGDLVINILKPRPLLESQNVKLRSYLLPPGT EFYYDIPNKDEKNINSCIEMVYQVGKLTDSRLRVVLQLFATIAHEPAFNQLRTREQLGYVVFSGMRVTRTTMGFRVLVQS ERNCIFLRQRIERFLLSLGEILEGYSDEKFNEFVSSLITRKLEKVQNFKEESNEYNTHVMSGYYHFNLRYEEAEMLKTVT KKEVLDMFYTYISPQSDKRSILIVNHMAHNPPAYTLEQVVGSVFSSLASKYEVDFEPSEAAELAAKASGLSPEEILQLAK GVLEEKGHGHIAEKFITEAAEEIALQSSPEPEERVGVPITSVSEFKSKLTLTEAPFPYKDLSEYVETEAKL
GO term prediction
Biological Process
GO:0006508 proteolysis
Molecular Function
GO:0003824 catalytic activity
GO:0004222 metalloendopeptidase activity
GO:0046872 metal ion binding
Cellular Component
None predicted.