Protein

MCA_00333_1

Length
787 amino acids

Gene name: ACO1

Description: Aconitate hydratase, mitochondrial

Browser: contigA:1030749-1033468+

RNA-seq: read pairs 90690, FPKM 1422.0, percentile rank 97.2% (100% = highest expression)

Protein function

Annotation:ACO1Aconitate hydratase, mitochondrial
KEGG:K01681ACO aconitate hydratase [EC:4.2.1.3]
EGGNOG:0PGE5ACO1aconitate hydratase
SGD closest match:S000004295ACO1Aconitate hydratase, mitochondrial
CGD closest match:CAL0000182282ACO1Aconitate hydratase, mitochondrial

Protein alignments

%idAln lengthE-value
MIA_00050_189.13%7820.0MIA_00050_1
A0A0J9X9G5_GEOCN85.55%7820.0Aconitate hydratase, mitochondrial OS=Geotrichum candidum GN=BN980_GECA06s01352g PE=3 SV=1
Q6C9P6_YARLI82.93%7500.0Aconitate hydratase, mitochondrial OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D09361g PE=3 SV=2
ACON_YEAST81.24%7570.0Aconitate hydratase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ACO1 PE=1 SV=2
UniRef50_P1941481.24%7570.0Aconitate hydratase, mitochondrial n=3013 Tax=root TaxID=1 RepID=ACON_YEAST
A0A060TGU8_BLAAD82.53%7440.0Aconitate hydratase, mitochondrial OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D26070g PE=3 SV=1
ACON_CANAL80.21%7530.0Aconitate hydratase, mitochondrial OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ACO1 PE=1 SV=2
A0A1E3PRH9_9ASCO81.46%7550.0Aconitate hydratase, mitochondrial OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_39427 PE=3 SV=1
A0A1E4TLE0_9ASCO77.48%7550.0Aconitate hydratase, mitochondrial OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_88989 PE=3 SV=1
A0A167DQK3_9ASCO84.28%6680.0Aconitate hydratase ACO1 OS=Sugiyamaella lignohabitans GN=ACO1 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9870
Predicted cleavage: 30

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 787

Detailed signature matches

  1. Family IPR006248
    Aconitase, mitochondrial-like
    1. TIGR01340
  2. Domain IPR015931
    Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3
    1. G3DSA:3.30.49...
  3. Domain IPR001030
    Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain
    1. PR00415 (ACONITASE)
    2. SSF53732 (Aconitase...)
    3. PF00330 (Aconitase)
  4. Domain IPR015932
    Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2
    1. G3DSA:3.40.10...
  5. Domain IPR015928
    Aconitase/3-isopropylmalate dehydratase, swivel
    1. G3DSA:3.20.19.10
    2. SSF52016 (LeuD/IlvD...)
  6. Domain IPR000573
    Aconitase A/isopropylmalate dehydratase small subunit, swivel domain
    1. PF00694 (Aconitase_C)
  7. SITE IPR018136
    Aconitase family, 4Fe-4S cluster binding site
    1. PS00450 (ACONITASE_1)
    2. PS01244 (ACONITASE_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. cd01584 (AcnA_Mitoc...)

Residue annotation

  1. substrate binding ...
  2. ligand binding sit...

Protein sequence

>MCA_00333_1
MLSATRLQALKSGSTIRAARSLATAASSQITRDSKVRQNIHEANNFINYKKNLENVEIVKARLGRPLTYGEKILYGHLDK
PHEQDIVRGESYLKLRPDRAACQDATAQMAILQFMSAGLPEVATPVTVHADHLIQAQVGGPKDLARAKDINKEVYDFLAT
ATAKYNIGFWGPGSGIIHQIILENYAFPGALLIGSDSHTPNAGGLGQLAIGVGGADVVDVMAGLPWELKAPKYIGVKLTG
KLNGWTSPKDVILKLAGILTVKGGTGFIVEYFGEGVEALSCTGMGTICNMGAEIGATTSVFPFNPRMSEYLNATSRADIA
TFGELYAKDLLKADEGAEYDQVVEIDLNTLEPYVNGPFTPDLATPISQMKEVAVKNDWPLEVKVGLIGSCTNSSYEDMSR
SASIIRDAMAHGLKSKAIFTVTPGSEQIRATIERDGQLQTFLDFGGLVLANACGPCIGQWDRRDIKKGDKNTIVSSYNRN
FTARNDGNPATHAFVTSPDLVTAYAIAGDLRFNPITDYLKDKDGKEFKLAEPEGFGLPTNGYDPGVDTYQAPPEDRSSVQ
VAVSPTSDRLQLLEPFKPWDGTDGKDMPILIKSKGKTTTDHISMAGPWLKYRGHLQNISNNYMIGAINWENGEANKVRNQ
FTGEFDTVPATAIKYRDAGVRWVVVGGENFGEGSSREHAALEPRYLGGFAIITKSFARIHETNLKKQGLLPLNFKNPEDY
DKINPDDRIDLVGLKDLAPGKPVKMIVHPKNGEPWESTLTHTFNPEQLEWFKHGSALNKMKADALKK

GO term prediction

Biological Process

GO:0006099 tricarboxylic acid cycle
GO:0008152 metabolic process

Molecular Function

GO:0003994 aconitate hydratase activity
GO:0051539 4 iron, 4 sulfur cluster binding

Cellular Component

None predicted.