MCA_00281_1

Protein

Length

789 amino acids

Gene name: SNF1

Description: Carbon catabolite-derepressing protein kinase; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis

Browser: contigA:855694-858064+

RNA-seq: read pairs 4417, FPKM 69.1, percentile rank 72.3% (100% = highest expression)

Protein function

Annotation:		SNF1	Carbon catabolite-derepressing protein kinase; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis
KEGG:	K12761	SNF1	carbon catabolite-derepressing protein kinase [EC:2.7.11.1]
EGGNOG:	0PGMD	SNF1	carbon catabolite derepressing protein kinase
SGD closest match:	S000002885	SNF1	Carbon catabolite-derepressing protein kinase
CGD closest match:	CAL0000201729	SNF1	Non-specific serine/threonine protein kinase

Protein alignments

	%id	Aln length
MIA_01361_1	70.81%	805	MIA_01361_1
A0A167CKS8_9ASCO	60.00%	700	Non-specific serine/threonine protein kinase OS=Sugiyamaella lignohabitans GN=SNF1 PE=4 SV=1
A0A0J9XC77_GEOCN	69.70%	571	Non-specific serine/threonine protein kinase OS=Geotrichum candidum GN=BN980_GECA08s04839g PE=4 SV=1
A0A1E3PKP0_9ASCO	55.33%	788	Non-specific serine/threonine protein kinase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82881 PE=4 SV=1
Q6CAK0_YARLI	65.57%	549	Non-specific serine/threonine protein kinase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D02101g PE=4 SV=1
A0A060T7P0_BLAAD	65.73%	572	Non-specific serine/threonine protein kinase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D01078g PE=4 SV=1
A0A1E4TF32_9ASCO	61.68%	548	Non-specific serine/threonine protein kinase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_24132 PE=4 SV=1
UniRef50_G8XZL3	60.14%	562	Non-specific serine/threonine protein kinase n=2 Tax=Pichia sorbitophila (strain ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC 10061 / NRRL Y-12695) TaxID=559304 RepID=G8XZL3_PICSO
SNF1_YEAST	59.67%	548	Carbon catabolite-derepressing protein kinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SNF1 PE=1 SV=1
A0A1D8PN61_CANAL	58.84%	554	Non-specific serine/threonine protein kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SNF1 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0278

Protein family membership

None predicted.

Domains and repeats

Domain
22 - 277
Protein kinase-like domain (IPR011009)
Protein kinase domain (IPR000719)
319 - 367
Carbon catabolite-derepressing protein kinase, ubiquitin-associated domain (IPR013896)
466 - 558
KA1 domain/Ssp2, C-terminal (IPR028375)
AMPK, C-terminal adenylate sensor domain (IPR032270)
662 - 713
KA1 domain/Ssp2, C-terminal (IPR028375)
AMPK, C-terminal adenylate sensor domain (IPR032270)
765 - 785
KA1 domain/Ssp2, C-terminal (IPR028375)

1 100 200 300 400 500 600 700 789

Detailed signature matches

IPR011009

Protein kinase-like domain
1. SSF56112 (Protein k...)
  
  22 - 277
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR000719

Protein kinase domain
1. PS50011 (PROTEIN_KI...)
  
  25 - 276
  
  PROSITE profiles
  PS50011 (PROTEIN_KINASE_DOM)
2. SM00220 (serkin_6)
  
  25 - 276
  
  SMART
  SM00220 (serkin_6)
3. PF00069 (Pkinase)
  
  25 - 276
  
  Pfam
  PF00069 (Pkinase)
IPR013896

Carbon catabolite-derepressing protein kinase, ubiquitin-associated domain
1. PF08587 (UBA_2)
  
  319 - 362
  
  Pfam
  PF08587 (UBA_2)
2. cd14334 (UBA_SNF1_f...)
  
  319 - 367
  
  CDD
  cd14334 (UBA_SNF1_fungi)
IPR028375

KA1 domain/Ssp2, C-terminal
1. SSF103243 (KA1-like)
  
  765 - 785
  
  SUPERFAMILY
  SSF103243 (KA1-like)
  
  664 - 697
  
  SUPERFAMILY
  SSF103243 (KA1-like)
  
  466 - 554
  
  SUPERFAMILY
  SSF103243 (KA1-like)
IPR032270

AMPK, C-terminal adenylate sensor domain
1. PF16579 (AdenylateS...)
  
  507 - 558
  
  Pfam
  PF16579 (AdenylateSensor)
  
  662 - 713
  
  Pfam
  PF16579 (AdenylateSensor)
IPR017441

Protein kinase, ATP binding site
1. PS00107 (PROTEIN_KI...)
  
  31 - 54
  
  PROSITE patterns
  PS00107 (PROTEIN_KINASE_ATP)
IPR008271

Serine/threonine-protein kinase, active site
1. PS00108 (PROTEIN_KI...)
  
  143 - 155
  
  PROSITE patterns
  PS00108 (PROTEIN_KINASE_ST)

no IPR

Unintegrated signatures

G3DSA:1.10.51...

120 - 423

GENE3D
G3DSA:1.10.510.10 (G3DSA:1.10.510.10)
G3DSA:3.30.20...

1 - 119

GENE3D
G3DSA:3.30.200.20 (G3DSA:3.30.200.20)
G3DSA:3.30.31...

511 - 789

GENE3D
G3DSA:3.30.310.80 (G3DSA:3.30.310.80)
cd14079 (STKc_AMPK_...)

22 - 276

CDD
cd14079 (STKc_AMPK_alpha)
mobidb-lite (disord...)

286 - 321

MobiDB Lite
mobidb-lite (disorder_prediction)

563 - 582

MobiDB Lite
mobidb-lite (disorder_prediction)

696 - 754

MobiDB Lite
mobidb-lite (disorder_prediction)

401 - 448

MobiDB Lite
mobidb-lite (disorder_prediction)

591 - 655

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

ATP binding site c...

31L

ATP binding site
31L, 32G, 33E, 34G, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

32G

ATP binding site
31L, 32G, 33E, 34G, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

33E

ATP binding site
31L, 32G, 33E, 34G, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

34G

ATP binding site
31L, 32G, 33E, 34G, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

39V

ATP binding site
31L, 32G, 33E, 34G, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

52A

ATP binding site
31L, 32G, 33E, 34G, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

54K

ATP binding site
31L, 32G, 33E, 34G, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

86I

ATP binding site
31L, 32G, 33E, 34G, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

102I

ATP binding site
31L, 32G, 33E, 34G, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

103E

ATP binding site
31L, 32G, 33E, 34G, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

104F

ATP binding site
31L, 32G, 33E, 34G, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

105A

ATP binding site
31L, 32G, 33E, 34G, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

108E

ATP binding site
31L, 32G, 33E, 34G, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

151E

ATP binding site
31L, 32G, 33E, 34G, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

152N

ATP binding site
31L, 32G, 33E, 34G, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

154L

ATP binding site
31L, 32G, 33E, 34G, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

164A

ATP binding site
31L, 32G, 33E, 34G, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

165D

ATP binding site
31L, 32G, 33E, 34G, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)
active site cd14079

31L

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

32G

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

33E

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

34G

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

35S

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

39V

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

52A

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

54K

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

86I

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

102I

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

103E

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

104F

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

105A

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

108E

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

110F

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

111D

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

113I

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

146R

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

147D

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

149K

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

151E

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

152N

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

154L

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

164A

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

165D

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

168L

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

182C

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

183G

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

184S

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

185P

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

186N

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

188A

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

218G

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

219R

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

220L

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

221P

active site
31L, 32G, 33E, 34G, 35S, 39V, 52A, 54K, 86I, 102I, 103E, 104F, 105A, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)
polypeptide substr...

108E

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

110F

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

111D

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

113I

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

147D

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

149K

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

151E

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

168L

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

182C

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

183G

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

184S

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

185P

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

186N

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

188A

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

218G

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

219R

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

220L

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

221P

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219R, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)
activation loop (A...

164A

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171I, 172M, 173T, 174D, 175G, 176N, 177F, 178L, 179K, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

165D

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171I, 172M, 173T, 174D, 175G, 176N, 177F, 178L, 179K, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

166F

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171I, 172M, 173T, 174D, 175G, 176N, 177F, 178L, 179K, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

167G

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171I, 172M, 173T, 174D, 175G, 176N, 177F, 178L, 179K, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

168L

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171I, 172M, 173T, 174D, 175G, 176N, 177F, 178L, 179K, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

169S

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171I, 172M, 173T, 174D, 175G, 176N, 177F, 178L, 179K, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

170N

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171I, 172M, 173T, 174D, 175G, 176N, 177F, 178L, 179K, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

171I

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171I, 172M, 173T, 174D, 175G, 176N, 177F, 178L, 179K, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

172M

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171I, 172M, 173T, 174D, 175G, 176N, 177F, 178L, 179K, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

173T

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171I, 172M, 173T, 174D, 175G, 176N, 177F, 178L, 179K, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

174D

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171I, 172M, 173T, 174D, 175G, 176N, 177F, 178L, 179K, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

175G

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171I, 172M, 173T, 174D, 175G, 176N, 177F, 178L, 179K, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

176N

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171I, 172M, 173T, 174D, 175G, 176N, 177F, 178L, 179K, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

177F

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171I, 172M, 173T, 174D, 175G, 176N, 177F, 178L, 179K, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

178L

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171I, 172M, 173T, 174D, 175G, 176N, 177F, 178L, 179K, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

179K

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171I, 172M, 173T, 174D, 175G, 176N, 177F, 178L, 179K, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

180T

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171I, 172M, 173T, 174D, 175G, 176N, 177F, 178L, 179K, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

181S

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171I, 172M, 173T, 174D, 175G, 176N, 177F, 178L, 179K, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

182C

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171I, 172M, 173T, 174D, 175G, 176N, 177F, 178L, 179K, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

183G

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171I, 172M, 173T, 174D, 175G, 176N, 177F, 178L, 179K, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

184S

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171I, 172M, 173T, 174D, 175G, 176N, 177F, 178L, 179K, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

185P

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171I, 172M, 173T, 174D, 175G, 176N, 177F, 178L, 179K, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

186N

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171I, 172M, 173T, 174D, 175G, 176N, 177F, 178L, 179K, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)
heterotrimer inter...

172M

heterotrimer interface
172M, 173T, 174D, 175G, 176N, 177F, 196K, 197L, 199A, 202E, 262L
CDD
cd14079 (STKc_AMPK_alpha)

173T

heterotrimer interface
172M, 173T, 174D, 175G, 176N, 177F, 196K, 197L, 199A, 202E, 262L
CDD
cd14079 (STKc_AMPK_alpha)

174D

heterotrimer interface
172M, 173T, 174D, 175G, 176N, 177F, 196K, 197L, 199A, 202E, 262L
CDD
cd14079 (STKc_AMPK_alpha)

175G

heterotrimer interface
172M, 173T, 174D, 175G, 176N, 177F, 196K, 197L, 199A, 202E, 262L
CDD
cd14079 (STKc_AMPK_alpha)

176N

heterotrimer interface
172M, 173T, 174D, 175G, 176N, 177F, 196K, 197L, 199A, 202E, 262L
CDD
cd14079 (STKc_AMPK_alpha)

177F

heterotrimer interface
172M, 173T, 174D, 175G, 176N, 177F, 196K, 197L, 199A, 202E, 262L
CDD
cd14079 (STKc_AMPK_alpha)

196K

heterotrimer interface
172M, 173T, 174D, 175G, 176N, 177F, 196K, 197L, 199A, 202E, 262L
CDD
cd14079 (STKc_AMPK_alpha)

197L

heterotrimer interface
172M, 173T, 174D, 175G, 176N, 177F, 196K, 197L, 199A, 202E, 262L
CDD
cd14079 (STKc_AMPK_alpha)

199A

heterotrimer interface
172M, 173T, 174D, 175G, 176N, 177F, 196K, 197L, 199A, 202E, 262L
CDD
cd14079 (STKc_AMPK_alpha)

202E

heterotrimer interface
172M, 173T, 174D, 175G, 176N, 177F, 196K, 197L, 199A, 202E, 262L
CDD
cd14079 (STKc_AMPK_alpha)

262L

heterotrimer interface
172M, 173T, 174D, 175G, 176N, 177F, 196K, 197L, 199A, 202E, 262L
CDD
cd14079 (STKc_AMPK_alpha)

Protein sequence

>MCA_00281_1
MSEQNKHADVMPSLSASSAGRIGRYQIIKTLGEGSFGKVKLAYHLATHARVALKIINRKTLAKSDMQGRVEREISYLRLL
RHPHIIKLYDVIKSKDEIIMVIEFAGKELFDYIVQRGRMSEDEGRRFFQQIISAVDYCHRHKIVHRDLKPENLLLDDNLN
VKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYVMLCGRLPFDDEFIPALFKKISNGVFV
LPSHLSQGARHLLKRMLVVNPLDRITVREIIQDPWFSVNLDPSLLPPDMREEQERKKAAELESSSNPSSAPGSGGIEPID
DSLVGALGRTMGYSKEQVYEALRHKNGDGSEIRDAYQLVKDNRLMGNAAVRQGEMDRYLVEDSSTEENRLKQQQYQQMLA
QQQMYQSHGLSNPNSIPNSVTQSPASMSGLGSRPHSSSFSRDNPPALTFDRMQLPNALDIGGHKTPHTTIAVLPTSLPAY
HRASMIALGSSTMRRLNPVTTKKSKTRWHFGIRSRSYPLDVMGEIYRALKNLGAEWAVPNDDDLWTIHVRWKCVLPKSVK
RRKLGEDEDQSMTDTNTILSEKREASNISLNQLPEQSISQQQNVRQDSSDDSMNICEDESNTTQPESTPSASNQEDESMP
PLARSVSQKHHVDDDAEADYVAGEEETELMKMRIQLYQIEQNNYLVDFKFDGWEETTPSKNASTSRKASTSSTHKSIPSS
LQMAPAATGSLSSTSSSSNSMTPSATAAARSAAADVRKDKSEFDTFSAYPFLHLATRLIMELAVNSQSQ

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding

Cellular Component