Protein

MCA_00258_1

Length
232 amino acids

Gene name: CAB5

Description: Dephospho-CoA kinase

Browser: contigA:798374-799073-

RNA-seq: read pairs 1055, FPKM 55.9, percentile rank 67.9% (100% = highest expression)

Protein function

Annotation:CAB5Dephospho-CoA kinase
KEGG:K00859coaE dephospho-CoA kinase [EC:2.7.1.24]
EGGNOG:0PI3QFG05575.1Dephospho-CoA kinase
SGD closest match:S000002604CAB5Dephospho-CoA kinase CAB5
CGD closest match:CAL0000200133orf19.4005Putative dephospho-CoA kinase

Protein alignments

%idAln lengthE-value
MIA_05144_165.91%2202e-104MIA_05144_1
A0A0J9X2K8_GEOCN65.92%2234e-103Similar to Saccharomyces cerevisiae YDR196C CAB5 Probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis OS=Geotrichum candidum GN=BN980_GECA01s03167g PE=3 SV=1
A0A167CG21_9ASCO56.16%2193e-82Putative dephospho-CoA kinase OS=Sugiyamaella lignohabitans GN=CAB5 PE=3 SV=1
UniRef50_A0A167CG2156.16%2198e-79Putative dephospho-CoA kinase n=4 Tax=Saccharomycetales TaxID=4892 RepID=A0A167CG21_9ASCO
A0A060T5H3_BLAAD53.49%2155e-73ARAD1B11418p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B11418g PE=3 SV=1
Q6C296_YARLI50.23%2192e-66YALI0F09625p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F09625g PE=3 SV=1
CAB5_YEAST46.27%2012e-61Dephospho-CoA kinase CAB5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CAB5 PE=1 SV=1
A0A1E3PE73_9ASCO45.83%2163e-61CoaE-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84174 PE=3 SV=1
Q5AK15_CANAL42.92%2261e-54Putative dephospho-CoA kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.4005 PE=3 SV=1
A0A1E4TDK6_9ASCO43.26%2153e-54Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1580 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.3311
Predicted cleavage: 22

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 232

Detailed signature matches

  1. Family IPR001977
    Dephospho-CoA kinase
    1. TIGR00152
    2. PS51219 (DPCK)
    3. cd02022 (DPCK)
    4. MF_00376 (Dephospho...)
    5. PF01121 (CoaE)
  2. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. G3DSA:3.40.50...
  3. NON_CYTOPLASM... (N...)
  4. TMhelix
  5. TRANSMEMBRANE (Tran...)

Residue annotation

  1. CoA-binding site c...
  2. ATP-binding cd02022

Protein sequence

>MCA_00258_1
MIILGLTGGIATGKSTVSKRFKSFHNLPIVDADVIARQVVEPGTSAYKKIVDHFGSSILLPDGNLDRPALGRVVFNNEKE
RLFLNSVVHPAVRKEMLRQVAAAYIKGHDIVILDVPLLFESNLARFCSKTVVVTCDNDKQFERLRARDPHLSEEDAKSRI
AAQFSMEKKEKMATYVIDNNGSLEELYAQVDDLVRNVRPNYLINMAEWLGPPVVTGILAALLFAFRTSKPKL

GO term prediction

Biological Process

GO:0015937 coenzyme A biosynthetic process

Molecular Function

GO:0004140 dephospho-CoA kinase activity
GO:0005524 ATP binding

Cellular Component

None predicted.