Protein
MCA_00226_1
Length
449 amino acids
Gene name: RAM1
Description: Protein farnesyltransferase subunit beta
Browser: contigA:703015-704365-
RNA-seq: read pairs 1121, FPKM 30.8, percentile rank 53.5% (100% = highest expression)
Protein function
| Annotation: | RAM1 | Protein farnesyltransferase subunit beta | |
|---|---|---|---|
| KEGG: | K05954 | FNTB | protein farnesyltransferase subunit beta [EC:2.5.1.58] |
| EGGNOG: | 0PJMU | RAM1 | Farnesyltransferase beta subunit |
| SGD closest match: | S000002248 | RAM1 | Protein farnesyltransferase subunit beta |
| CGD closest match: | CAL0000199757 | RAM1 | Protein farnesyltransferase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_01274_1 | 63.17% | 410 | 0.0 | MIA_01274_1 |
| A0A0J9XFE9_GEOCN | 57.63% | 413 | 2e-171 | Similar to Saccharomyces cerevisiae YDL090C RAM1 Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins OS=Geotrichum candidum GN=BN980_GECA13s02122g PE=4 SV=1 |
| A0A060T2J9_BLAAD | 51.46% | 410 | 2e-140 | ARAD1A02112p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A02112g PE=4 SV=1 |
| A0A1E3PIC9_9ASCO | 54.41% | 397 | 1e-139 | Terpenoid cyclases/Protein prenyltransferase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46829 PE=4 SV=1 |
| A0A161HJ11_9ASCO | 50.24% | 410 | 1e-135 | Protein farnesyltransferase OS=Sugiyamaella lignohabitans GN=RAM1 PE=4 SV=1 |
| UniRef50_A0A161HJ11 | 50.24% | 410 | 3e-132 | Protein farnesyltransferase n=5 Tax=Ascomycota TaxID=4890 RepID=A0A161HJ11_9ASCO |
| A0A1E4THH0_9ASCO | 50.74% | 339 | 1e-104 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_57515 PE=4 SV=1 |
| Q6C928_YARLI | 40.58% | 414 | 3e-96 | YALI0D14762p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D14762g PE=4 SV=1 |
| FNTB_YEAST | 41.62% | 394 | 1e-82 | Protein farnesyltransferase subunit beta OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RAM1 PE=1 SV=2 |
| A0A1D8PLY3_CANAL | 33.33% | 411 | 7e-64 | Protein farnesyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=RAM1 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.9243
Predicted cleavage: 18
Protein family membership
- Protein farnesyltransferase subunit beta (IPR026872)
Domains and repeats
-
Domain
-
Repeat
1
50
100
150
200
250
300
350
400
449
Detailed signature matches
no IPR
Unintegrated signatures
Residue annotation
-
active site cavity...
-
peptide binding po...
-
lipid binding pock...
-
heterodimer interf...
-
Zn2+ binding site ...
Protein sequence
>MCA_00226_1 MKIRPTRARRDIKLFRKPAKSSKMQISSSNPMAFSPVIMSPLPKIPIYNNFVRDTLDTVTVTAQKETENDCLEIYTSPES TSLGILQRDLHIKFLRSHLGKLPSGFVSLDASRPWLCYWSLNALALLSEDISDLKEKANNTISMCLSPTGGIGGNFGYEA HLAATYAGTNTLALTADEETLSKIDTQKFYDWLIKLKQPDGGFAMHIGGECDTRAVYCALSVASLLDILTPELIENTTEY LTKCQTFEGGVSDSPGTEAHGGYAFCALAALCIMHPPTEVHKYINIPKLLKWLSSRQHQPEGGFSGRTNKLVDGCYSHWV GGCWAILETITGVTDLWDREALQNYTLYCCQTKGKGGLRDKPGKGADAYHSNYTLCGLAGAQNSYTYDEALAKEKNAKLG DYAYFWKSQTTDLIEINEKNLVAQINPIHVLPIGVAESFHEYFVKKKLI
GO term prediction
Biological Process
GO:0018343 protein farnesylation
GO:0042127 regulation of cell proliferation
Molecular Function
GO:0003824 catalytic activity
Cellular Component
GO:0005965 protein farnesyltransferase complex