Protein

MCA_00222_1

Length
453 amino acids

Gene name: GDH3

Description: NADP-specific glutamate dehydrogenase

Browser: contigA:688422-689784-

RNA-seq: read pairs 57642, FPKM 1568.8, percentile rank 97.4% (100% = highest expression)

Protein function

Annotation:GDH3NADP-specific glutamate dehydrogenase
KEGG:K00262E1.4.1.4 glutamate dehydrogenase (NADP+) [EC:1.4.1.4]
EGGNOG:0PGWMGDHAglutamate dehydrogenase
SGD closest match:S000000058GDH3NADP-specific glutamate dehydrogenase 2
CGD closest match:CAL0000180438GDH3Glutamate dehydrogenase

Protein alignments

%idAln lengthE-value
MIA_01282_187.42%4530.0MIA_01282_1
A0A023RBK5_GEOCN85.65%4530.0Glutamate dehydrogenase OS=Geotrichum candidum GN=GDH PE=2 SV=1
A0A060TCU4_BLAAD81.02%4530.0Glutamate dehydrogenase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D45870g PE=3 SV=1
A0A167E3N6_9ASCO77.48%4530.0Glutamate dehydrogenase OS=Sugiyamaella lignohabitans GN=GDH1 PE=3 SV=1
Q6C1A9_YARLI77.95%4580.0Glutamate dehydrogenase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F17820g PE=3 SV=1
A0A1E3PTI2_9ASCO76.21%4540.0Glutamate dehydrogenase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49279 PE=3 SV=1
A0A1E4TE45_9ASCO77.92%4530.0Glutamate dehydrogenase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1706 PE=3 SV=1
UniRef50_A0A0A2KN9073.25%4560.0Glutamate/phenylalanine/leucine/valine dehydrogenase n=1 Tax=Penicillium italicum TaxID=40296 RepID=A0A0A2KN90_PENIT
A0A1D8PMH8_CANAL71.30%4600.0Glutamate dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GDH3 PE=3 SV=1
DHE5_YEAST68.05%4570.0NADP-specific glutamate dehydrogenase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GDH3 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0245

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 453

Detailed signature matches

  1. Family IPR006095
    Glutamate/phenylalanine/leucine/valine dehydrogenase
    1. PR00082 (GLFDHDRGNASE)
  2. Family IPR014362
    Glutamate dehydrogenase
    1. PIRSF000185 (Glu_DH)
  3. Domain IPR006097
    Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain
    1. PF02812 (ELFV_dehyd...)
  4. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  5. Domain IPR006096
    Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal
    1. PF00208 (ELFV_dehydrog)
    2. SM00839 (ELFV_dehyd...)
  6. Domain IPR033922
    NAD(P) binding domain of glutamate dehydrogenase
    1. cd05313 (NAD_bind_2...)
  7. SITE IPR033524
    Leu/Phe/Val dehydrogenases active site
    1. PS00074 (GLFV_DEHYD...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.10.28...
  3. G3DSA:3.40.50...
  4. G3DSA:3.40.50...
  5. SSF53223 (Aminoacid...)

Residue annotation

  1. NAD(P) binding sit...

Protein sequence

>MCA_00222_1
MVQPSEPEFEQAYNELLSTLKDSTLFEKRPELEKVIPIVSIPERVIQFRVTWEDDNGNVQVNRGYRVQFNSALGPYKGGL
RFHPTVNLSILKFLGYEQIFKNALTGLNMGGGKGGSDFDPKGKSDNEIRRFCYAFMSELHRHIGADTDVPAGDINVGGRE
IGFLFGAFKKFHNSWEGVLTGKGLTWGGSLIRPEATGYGVVYYVEKMIEYSSQGKDSFKGKRVAISGSGNVAQFAALKVI
DLGGIVVSLSDSKGAFVAKTAEGFTPAEIAEIADLKLKRKSLSELAEKYSAKYDYLEGARPWAKVGKVDVALPSATQNEV
SGDEAKALVEAGCKFVAEGSNMGCTLEAIEVFENERLASPKGIWYAPGKAANAGGVAVSGLEMAQNSQRSTWSTEEVDNK
LKEIMVNIFNNCVDTAIEYSSEKGDALPSLVKGANIAGFVKVSEAMASHGDFW

GO term prediction

Biological Process

GO:0006520 cellular amino acid metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004352 glutamate dehydrogenase (NAD+) activity
GO:0016491 oxidoreductase activity
GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

Cellular Component

None predicted.