Protein

MCA_00186_1

Length
689 amino acids

Gene name: VPS1

Description: Vacuolar protein sorting-associated protein 1

Browser: contigA:556183-558384+

RNA-seq: read pairs 6564, FPKM 117.5, percentile rank 81.4% (100% = highest expression)

Protein function

Annotation:VPS1Vacuolar protein sorting-associated protein 1
KEGG:K17065DNM1L dynamin 1-like protein [EC:3.6.5.5]
EGGNOG:0PIARVPS1vacuolar sorting protein
SGD closest match:S000001709VPS1Vacuolar protein sorting-associated protein 1
CGD closest match:CAL0000198753VPS1Dynamin-like GTPase

Protein alignments

%idAln lengthE-value
MIA_01357_183.55%7050.0MIA_01357_1
A0A0J9X696_GEOCN81.01%6900.0Similar to Saccharomyces cerevisiae YKR001C VPS1 Dynamin-like GTPase required for vacuolar sorting OS=Geotrichum candidum GN=BN980_GECA03s05818g PE=3 SV=1
A0A060TDL4_BLAAD78.10%6940.0ARAD1D01166p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D01166g PE=3 SV=1
Q6C9N5_YARLI76.20%6890.0YALI0D09713p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D09713g PE=3 SV=1
A0A161HFT2_9ASCO72.96%7100.0Dynamin-like GTPase VPS1 OS=Sugiyamaella lignohabitans GN=VPS1 PE=3 SV=1
A0A1E3PM29_9ASCO71.28%6930.0Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82880 PE=3 SV=1
UniRef50_P2157668.41%7060.0Vacuolar protein sorting-associated protein 1 n=490 Tax=Fungi TaxID=4751 RepID=VPS1_YEAST
VPS1_YEAST68.41%7060.0Vacuolar protein sorting-associated protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VPS1 PE=1 SV=2
A0A1D8PN45_CANAL68.97%6960.0Dynamin-like GTPase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=VPS1 PE=3 SV=1
A0A1E4TA19_9ASCO68.69%6930.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_125679 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.3015

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 100 200 300 400 500 600 689

Detailed signature matches

  1. Family IPR022812
    Dynamin superfamily
    1. PF00350 (Dynamin_N)
    2. PR00195 (DYNAMIN)
  2. Domain IPR001401
    Dynamin, GTPase domain
    1. SM00053 (dynamin_3)
  3. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  4. Domain IPR030381
    Dynamin-type guanine nucleotide-binding (G) domain
    1. PS51718 (G_DYNAMIN_2)
  5. Domain IPR000375
    Dynamin central domain
    1. PF01031 (Dynamin_M)
  6. Domain IPR020850
    GTPase effector domain
    1. PS51388 (GED)
  7. Domain IPR003130
    Dynamin GTPase effector
    1. SM00302 (GED_2)
    2. PF02212 (GED)
  8. SITE IPR019762
    Dynamin, GTPase region, conserved site
    1. PS00410 (G_DYNAMIN_1)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. cd08771 (DLP_1)
  3. mobidb-lite (disord...)

Residue annotation

  1. G1 box cd08771
  2. GTP/Mg2+ binding s...
  3. homodimer interfac...
  4. G2 box cd08771
  5. Switch I region cd...
  6. G3 box cd08771
  7. Switch II region c...
  8. G4 box cd08771
  9. G5 box cd08771

Protein sequence

>MCA_00186_1
MDQHLIDTVNRLQDALATLGPGANPIDLPQITVVGSQSSGKSSVLENIVGRDFLPRGTGIVTRRPLILQLINRRPTQSSE
TKPPETNGTAKAEDDSSDRKNETNPDEWGEFLHKPGQKYFDFNEIRKEIVRETELKTGKNAGISSVPINLRIYSPHVLTL
TLVDLPGLTKVPVGDQPKDIEIQIKEMVLKFITKPNAIILSVTAANTDLANSDGLKLAREVDPEGARTIGVLTKIDLMDQ
GTDVIDILAGRVIPLRYGYVPVINRGQKDITSNKSIKAALQFEKEFFENHPAYRAKAQYCGTPYLAKRLNSILLNHIKNT
LPDIKSRIDNTLKKYQSELITLGPPDLGSPSSVVLSTITEFSNEYKSVLDGQSNDVSSLELSGGARISFVFHEIFSHGIN
ALDPFDQIKDVDIRTILYNSSGSSPNLFIGTGAFEVLVKKQIKRFEEPSLKCVTLVYDELVRILTQILAKPQFSRYPALK
ESIHNVFIGLLRKSLIPTNKLVDDLVSMEEAYINTAHPDLIKGSHAMAIVSEKLQLSKPVQLDPKTGKPYPNQQPVPALQ
EDNGGFFSNFFASKNKKRLAAMEPPPATLRASGQMTERETLETEVIKMLIESYFSIVQRTIIDLVPKAIMQKLINFSKQE
VQKELLENLYKSESIDDLVKENEYTVQRRKEVEAMVKALTHASEIVTSV

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003924 GTPase activity
GO:0005525 GTP binding

Cellular Component

None predicted.