Protein

MCA_00158_1

Length
360 amino acids

Gene name: HOM2

Description: Aspartate-semialdehyde dehydrogenase

Browser: contigA:429459-430598+

RNA-seq: read pairs 9015, FPKM 308.6, percentile rank 92.0% (100% = highest expression)

Protein function

Annotation:HOM2Aspartate-semialdehyde dehydrogenase
KEGG:K00133asd aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]
EGGNOG:0PHPFFG08498.1aspartate-semialdehyde dehydrogenase
SGD closest match:S000002565HOM2Aspartate-semialdehyde dehydrogenase
CGD closest match:CAL0000179646HOM2Aspartate-semialdehyde dehydrogenase

Protein alignments

%idAln lengthE-value
MIA_00504_185.52%3590.0MIA_00504_1
A0A0J9XBW1_GEOCN73.18%3580.0Similar to Saccharomyces cerevisiae YDR158W HOM2 Aspartic beta semi-aldehyde dehydrogenase OS=Geotrichum candidum GN=BN980_GECA07s02991g PE=4 SV=1
A0A1E3PQ94_9ASCO70.83%3606e-179Aspartate-semialdehyde dehydrogenase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82043 PE=4 SV=1
Q6C968_YARLI68.03%3662e-175YALI0D13596p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D13596g PE=4 SV=1
DHAS_YEAST66.30%3622e-168Aspartate-semialdehyde dehydrogenase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HOM2 PE=1 SV=1
UniRef50_P1366366.30%3625e-165Aspartate-semialdehyde dehydrogenase n=475 Tax=Fungi TaxID=4751 RepID=DHAS_YEAST
Q5ALM0_CANAL66.30%3627e-166Aspartate-semialdehyde dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HOM2 PE=1 SV=1
A0A060SY03_BLAAD66.38%3541e-163ARAD1A12958p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A12958g PE=4 SV=1
A0A1E4TL18_9ASCO63.10%3557e-155Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1043 PE=4 SV=1
A0A161HUV0_9ASCO64.88%1684e-68Aspartate-semialdehyde dehydrogenase OS=Sugiyamaella lignohabitans GN=HOM2 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1993
Predicted cleavage: 44

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 360

Detailed signature matches

  1. Family IPR005676
    Aspartate-semialdehyde dehydrogenase, peptidoglycan lacking
    1. TIGR00978
  2. Domain IPR000534
    Semialdehyde dehydrogenase, NAD-binding
    1. SM00859 (Semialdhyd...)
    2. PF01118 (Semialdhyd...)
  3. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  4. Domain IPR012280
    Semialdehyde dehydrogenase, dimerisation domain
    1. PF02774 (Semialdhyd...)
  5. SITE IPR000319
    Aspartate-semialdehyde dehydrogenase, conserved site
    1. PS01103 (ASD)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.30.36...
  2. G3DSA:3.40.50...
  3. PIRSF000148 (ASA_dh)
  4. SSF55347 (Glycerald...)

Protein sequence

>MCA_00158_1
MVSTEKKKAGVLGATGSVGQRFMQLLANHPNFELAVLGASKRSAGKEYVEAAEWKQAVPLPKNVANLVVKECIPENFKEC
DVVFSGLDADYAGEIEKAFVEAGLVIISNAKNYRRDPNVPLVVPTCNPEHLDICKKLKEKNKGFQVCISNCSTAGLVVPL
KALTEKFGPISTMVVTTMQAISGAGFSPGISSMDIIDNLIPYIGSEEDKLEWEPRKILAPIAADGISFDIIPEEEFKISA
ACNRVAVIDGHTECISLKFKQSPPPSVEEVKAALREFKSPVQELGCHSAPKQVIHVFEQPNRPQPRLDRDLDNGYACSVG
RVRTDPVFDIKFVALSHNTIIGAAGSGILIAETLLAKKLI

GO term prediction

Biological Process

GO:0006520 cellular amino acid metabolic process
GO:0006531 aspartate metabolic process
GO:0008652 cellular amino acid biosynthetic process
GO:0009086 methionine biosynthetic process
GO:0009088 threonine biosynthetic process
GO:0009089 lysine biosynthetic process via diaminopimelate
GO:0009097 isoleucine biosynthetic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0003942 N-acetyl-gamma-glutamyl-phosphate reductase activity
GO:0004073 aspartate-semialdehyde dehydrogenase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0046983 protein dimerization activity
GO:0050661 NADP binding
GO:0051287 NAD binding

Cellular Component

GO:0005737 cytoplasm