MCA_00037_1

Protein

Length

150 amino acids

Gene name: SRX1

Description: Sulfiredoxin

Browser: contigA:89120-89573+

RNA-seq: read pairs 4207, FPKM 344.3, percentile rank 92.7% (100% = highest expression)

Protein function

Annotation:		SRX1	Sulfiredoxin
KEGG:	K12260	SRX1	sulfiredoxin [EC:1.8.98.2]
EGGNOG:	0PNZ8	SRX1	K12260 sulfiredoxin EC 1.8.98.2
SGD closest match:	S000001569	SRX1	Sulfiredoxin
CGD closest match:	CAL0000196707	orf19.3537	Sulfiredoxin

Protein alignments

	%id	Aln length	E-value
MIA_04039_1	56.97%	165	1e-60	MIA_04039_1
A0A1E3PDY2_9ASCO	38.93%	149	6e-31	Sulfiredoxin OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_53241 PE=3 SV=1
UniRef50_A0A1E3PDY2	38.93%	149	2e-27	Sulfiredoxin n=1 Tax=Nadsonia fulvescens var. elongata DSM 6958 TaxID=857566 RepID=A0A1E3PDY2_9ASCO
A0A0J9XHH7_GEOCN	38.51%	148	1e-30	Similar to Saccharomyces cerevisiae YKL086W SRX1 Sulfiredoxin (Partial) (Fragment) OS=Geotrichum candidum GN=BN980_GECA16s02930g PE=4 SV=1
Q59ZI2_CANAL	39.04%	146	1e-25	Sulfiredoxin OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.3537 PE=3 SV=1
Q6C8V4_YARLI	37.58%	149	1e-25	Sulfiredoxin OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D16709g PE=3 SV=1
SRX1_YEAST	37.09%	151	4e-23	Sulfiredoxin OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SRX1 PE=1 SV=1
A0A1E4TL25_9ASCO	36.11%	144	3e-22	Sulfiredoxin OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30594 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.6610

Protein family membership

Sulfiredoxin (IPR016692)

Domains and repeats

Domain
3 - 144
ParB/Sulfiredoxin (IPR003115)

1 20 40 60 80 100 120 140 150

Detailed signature matches

IPR016692

Sulfiredoxin
1. PIRSF017267 (Sulfir...)
  
  65 - 149
  
  PIRSF
  PIRSF017267 (Sulfiredoxin)
  
  1 - 75
  
  PIRSF
  PIRSF017267 (Sulfiredoxin)
IPR003115

ParB/Sulfiredoxin
1. PF02195 (ParBc)
  
  18 - 143
  
  Pfam
  PF02195 (ParBc)
2. SSF110849 (ParB/Sul...)
  
  3 - 41
  
  SUPERFAMILY
  SSF110849 (ParB/Sulfiredoxin)
  
  85 - 144
  
  SUPERFAMILY
  SSF110849 (ParB/Sulfiredoxin)

no IPR

Unintegrated signatures

G3DSA:3.90.15...

8 - 144

GENE3D
G3DSA:3.90.1530.10 (G3DSA:3.90.1530.10)
cd16395 (Srx)

11 - 141

CDD
cd16395 (Srx)
mobidb-lite (disord...)

61 - 88

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

peroxiredoxin bind...

12M

peroxiredoxin binding site
12M, 13Y, 14L, 15P, 20R, 21R, 22P, 23I, 24L, 92D, 94L, 95M, 102R, 103Y, 104Y, 107F, 108G, 125K, 128I, 129T, 134S, 137R, 138I
CDD
cd16395 (Srx)

13Y

peroxiredoxin binding site
12M, 13Y, 14L, 15P, 20R, 21R, 22P, 23I, 24L, 92D, 94L, 95M, 102R, 103Y, 104Y, 107F, 108G, 125K, 128I, 129T, 134S, 137R, 138I
CDD
cd16395 (Srx)

14L

peroxiredoxin binding site
12M, 13Y, 14L, 15P, 20R, 21R, 22P, 23I, 24L, 92D, 94L, 95M, 102R, 103Y, 104Y, 107F, 108G, 125K, 128I, 129T, 134S, 137R, 138I
CDD
cd16395 (Srx)

15P

peroxiredoxin binding site
12M, 13Y, 14L, 15P, 20R, 21R, 22P, 23I, 24L, 92D, 94L, 95M, 102R, 103Y, 104Y, 107F, 108G, 125K, 128I, 129T, 134S, 137R, 138I
CDD
cd16395 (Srx)

20R

peroxiredoxin binding site
12M, 13Y, 14L, 15P, 20R, 21R, 22P, 23I, 24L, 92D, 94L, 95M, 102R, 103Y, 104Y, 107F, 108G, 125K, 128I, 129T, 134S, 137R, 138I
CDD
cd16395 (Srx)

21R

peroxiredoxin binding site
12M, 13Y, 14L, 15P, 20R, 21R, 22P, 23I, 24L, 92D, 94L, 95M, 102R, 103Y, 104Y, 107F, 108G, 125K, 128I, 129T, 134S, 137R, 138I
CDD
cd16395 (Srx)

22P

peroxiredoxin binding site
12M, 13Y, 14L, 15P, 20R, 21R, 22P, 23I, 24L, 92D, 94L, 95M, 102R, 103Y, 104Y, 107F, 108G, 125K, 128I, 129T, 134S, 137R, 138I
CDD
cd16395 (Srx)

23I

peroxiredoxin binding site
12M, 13Y, 14L, 15P, 20R, 21R, 22P, 23I, 24L, 92D, 94L, 95M, 102R, 103Y, 104Y, 107F, 108G, 125K, 128I, 129T, 134S, 137R, 138I
CDD
cd16395 (Srx)

24L

peroxiredoxin binding site
12M, 13Y, 14L, 15P, 20R, 21R, 22P, 23I, 24L, 92D, 94L, 95M, 102R, 103Y, 104Y, 107F, 108G, 125K, 128I, 129T, 134S, 137R, 138I
CDD
cd16395 (Srx)

92D

peroxiredoxin binding site
12M, 13Y, 14L, 15P, 20R, 21R, 22P, 23I, 24L, 92D, 94L, 95M, 102R, 103Y, 104Y, 107F, 108G, 125K, 128I, 129T, 134S, 137R, 138I
CDD
cd16395 (Srx)

94L

peroxiredoxin binding site
12M, 13Y, 14L, 15P, 20R, 21R, 22P, 23I, 24L, 92D, 94L, 95M, 102R, 103Y, 104Y, 107F, 108G, 125K, 128I, 129T, 134S, 137R, 138I
CDD
cd16395 (Srx)

95M

peroxiredoxin binding site
12M, 13Y, 14L, 15P, 20R, 21R, 22P, 23I, 24L, 92D, 94L, 95M, 102R, 103Y, 104Y, 107F, 108G, 125K, 128I, 129T, 134S, 137R, 138I
CDD
cd16395 (Srx)

102R

peroxiredoxin binding site
12M, 13Y, 14L, 15P, 20R, 21R, 22P, 23I, 24L, 92D, 94L, 95M, 102R, 103Y, 104Y, 107F, 108G, 125K, 128I, 129T, 134S, 137R, 138I
CDD
cd16395 (Srx)

103Y

peroxiredoxin binding site
12M, 13Y, 14L, 15P, 20R, 21R, 22P, 23I, 24L, 92D, 94L, 95M, 102R, 103Y, 104Y, 107F, 108G, 125K, 128I, 129T, 134S, 137R, 138I
CDD
cd16395 (Srx)

104Y

peroxiredoxin binding site
12M, 13Y, 14L, 15P, 20R, 21R, 22P, 23I, 24L, 92D, 94L, 95M, 102R, 103Y, 104Y, 107F, 108G, 125K, 128I, 129T, 134S, 137R, 138I
CDD
cd16395 (Srx)

107F

peroxiredoxin binding site
12M, 13Y, 14L, 15P, 20R, 21R, 22P, 23I, 24L, 92D, 94L, 95M, 102R, 103Y, 104Y, 107F, 108G, 125K, 128I, 129T, 134S, 137R, 138I
CDD
cd16395 (Srx)

108G

peroxiredoxin binding site
12M, 13Y, 14L, 15P, 20R, 21R, 22P, 23I, 24L, 92D, 94L, 95M, 102R, 103Y, 104Y, 107F, 108G, 125K, 128I, 129T, 134S, 137R, 138I
CDD
cd16395 (Srx)

125K

peroxiredoxin binding site
12M, 13Y, 14L, 15P, 20R, 21R, 22P, 23I, 24L, 92D, 94L, 95M, 102R, 103Y, 104Y, 107F, 108G, 125K, 128I, 129T, 134S, 137R, 138I
CDD
cd16395 (Srx)

128I

peroxiredoxin binding site
12M, 13Y, 14L, 15P, 20R, 21R, 22P, 23I, 24L, 92D, 94L, 95M, 102R, 103Y, 104Y, 107F, 108G, 125K, 128I, 129T, 134S, 137R, 138I
CDD
cd16395 (Srx)

129T

peroxiredoxin binding site
12M, 13Y, 14L, 15P, 20R, 21R, 22P, 23I, 24L, 92D, 94L, 95M, 102R, 103Y, 104Y, 107F, 108G, 125K, 128I, 129T, 134S, 137R, 138I
CDD
cd16395 (Srx)

134S

peroxiredoxin binding site
12M, 13Y, 14L, 15P, 20R, 21R, 22P, 23I, 24L, 92D, 94L, 95M, 102R, 103Y, 104Y, 107F, 108G, 125K, 128I, 129T, 134S, 137R, 138I
CDD
cd16395 (Srx)

137R

peroxiredoxin binding site
12M, 13Y, 14L, 15P, 20R, 21R, 22P, 23I, 24L, 92D, 94L, 95M, 102R, 103Y, 104Y, 107F, 108G, 125K, 128I, 129T, 134S, 137R, 138I
CDD
cd16395 (Srx)

138I

peroxiredoxin binding site
12M, 13Y, 14L, 15P, 20R, 21R, 22P, 23I, 24L, 92D, 94L, 95M, 102R, 103Y, 104Y, 107F, 108G, 125K, 128I, 129T, 134S, 137R, 138I
CDD
cd16395 (Srx)
active site cd16395

21R

active site
21R, 110C, 111H, 112R
CDD
cd16395 (Srx)

110C

active site
21R, 110C, 111H, 112R
CDD
cd16395 (Srx)

111H

active site
21R, 110C, 111H, 112R
CDD
cd16395 (Srx)

112R

active site
21R, 110C, 111H, 112R
CDD
cd16395 (Srx)
ATP binding site c...

31K

ATP binding site
31K, 34A, 35M, 38T, 87D, 89T, 108G, 109G, 110C, 111H, 112R
CDD
cd16395 (Srx)

34A

ATP binding site
31K, 34A, 35M, 38T, 87D, 89T, 108G, 109G, 110C, 111H, 112R
CDD
cd16395 (Srx)

35M

ATP binding site
31K, 34A, 35M, 38T, 87D, 89T, 108G, 109G, 110C, 111H, 112R
CDD
cd16395 (Srx)

38T

ATP binding site
31K, 34A, 35M, 38T, 87D, 89T, 108G, 109G, 110C, 111H, 112R
CDD
cd16395 (Srx)

87D

ATP binding site
31K, 34A, 35M, 38T, 87D, 89T, 108G, 109G, 110C, 111H, 112R
CDD
cd16395 (Srx)

89T

ATP binding site
31K, 34A, 35M, 38T, 87D, 89T, 108G, 109G, 110C, 111H, 112R
CDD
cd16395 (Srx)

108G

ATP binding site
31K, 34A, 35M, 38T, 87D, 89T, 108G, 109G, 110C, 111H, 112R
CDD
cd16395 (Srx)

109G

ATP binding site
31K, 34A, 35M, 38T, 87D, 89T, 108G, 109G, 110C, 111H, 112R
CDD
cd16395 (Srx)

110C

ATP binding site
31K, 34A, 35M, 38T, 87D, 89T, 108G, 109G, 110C, 111H, 112R
CDD
cd16395 (Srx)

111H

ATP binding site
31K, 34A, 35M, 38T, 87D, 89T, 108G, 109G, 110C, 111H, 112R
CDD
cd16395 (Srx)

112R

ATP binding site
31K, 34A, 35M, 38T, 87D, 89T, 108G, 109G, 110C, 111H, 112R
CDD
cd16395 (Srx)
phosphorylation si...

110C

phosphorylation site
110C
CDD
cd16395 (Srx)

Protein sequence

>MCA_00037_1
MSIQTSNNKQIMYLPRHLIRRPILPVLDEEKITAMRETMDKHYKNRPKVVTEKGKELLEKGLPIPVSEIDEGKSPEGGSS
NDSQFEDMTPIDVLMVSDKGQRYYFGFGGCHRFQAYDRSEWDLVKVKITPTTKSQLRIYLGASVDSIFKD

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0032542 sulfiredoxin activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features