Protein

MCA_00030_1

Length
337 amino acids

Gene name: HEM25

Description: mitochondrial glycine transporter; solute carrier family 25 member 38

Browser: contigA:77694-78708+

RNA-seq: read pairs 2760, FPKM 100.9, percentile rank 78.8% (100% = highest expression)

Protein function

Annotation:HEM25mitochondrial glycine transporter; solute carrier family 25 member 38
KEGG:K15118SLC25A38 solute carrier family 25, member 38
EGGNOG:0PJEDPGUG_00074Mitochondrial carrier required for the biosynthesis of heme, possibly by facilitating 5-aminolevulinate (ALA) production. May act by importing glycine into mitochondria or by exchanging glycine for ALA across the mitochondrial inner membrane (By similarity)
SGD closest match:S000002277HEM25Solute carrier family 25 member 38 homolog
CGD closest match:CAL0000196262CAALFM_CR04920WASolute carrier family 25 member 38 homolog

Protein alignments

%idAln lengthE-value
MIA_04096_167.46%3351e-135MIA_04096_1
A0A0J9XH54_GEOCN62.80%3369e-132Solute carrier family 25 member 38 homolog OS=Geotrichum candidum GN=BN980_GECA16s01253g PE=3 SV=1
A0A167CJQ6_9ASCO52.91%3444e-109Solute carrier family 25 member 38 homolog OS=Sugiyamaella lignohabitans GN=AWJ20_9 PE=3 SV=1
A0A060T585_BLAAD53.50%3292e-109Solute carrier family 25 member 38 homolog OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B05478g PE=3 SV=1
A0A1E4TCI1_9ASCO49.50%3011e-90Solute carrier family 25 member 38 homolog OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_4094 PE=3 SV=1
UniRef50_A0A1E4TCI149.50%3015e-87Solute carrier family 25 member 38 homolog n=1 Tax=Tortispora caseinolytica NRRL Y-17796 TaxID=767744 RepID=A0A1E4TCI1_9ASCO
S2538_YARLI49.51%3071e-89Solute carrier family 25 member 38 homolog OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0E09284g PE=3 SV=1
A0A1E3PEG4_9ASCO47.11%3469e-87Solute carrier family 25 member 38 homolog OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83918 PE=3 SV=1
S2538_YEAST51.76%3132e-84Solute carrier family 25 member 38 homolog OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HEM25 PE=1 SV=1
S2538_CANAL41.62%3341e-62Solute carrier family 25 member 38 homolog OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_CR04920WA PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0431

Protein family membership

Domains and repeats

  1. Domain
  2. Repeat
1 50 100 150 200 250 300 337

Detailed signature matches

  1. Family IPR030847
    Solute carrier family 25 member 38
    1. MF_03064 (SLC25A38)
  2. Domain IPR023395
    Mitochondrial carrier domain
    1. G3DSA:1.50.40.10
    2. SSF103506 (Mitochon...)
  3. Repeat IPR018108
    Mitochondrial substrate/solute carrier
    1. PS50920 (SOLCAR)
    2. PF00153 (Mito_carr)
Unintegrated signatures no IPR
Unintegrated signatures
  1. mobidb-lite (disord...)

Protein sequence

>MCA_00030_1
MSSIPVPLPKASDDTIPPSAPPALKPTHKQASKTGSHLAAGFVSGLTSSVLLQPLDLLKTRVQQQKTQDGQKSSIRGTIK
NINSVKELWRGTSASAIRTSVGSALYLTLLNSTRTYLSKHQTIFSSNSTTKSTGISSALPKLSMHTNLLSGAMVRGFVGI
ITMPVTVVKVRYESSMYNYSSLGNAIKDIYSQHGVRGFFKGWGVTFLRDSPNAGLYVLFYELWKDVLSRSVSVLSMSPNA
VSSTPKLFDTSTSALINSSSAILSAGMATTITGPFDTIKTRIQLDPVRYNSVWKSVQLIIKEEGLRGLFDGLSLRMARKA
MSAGISWCIYEELVRRM

GO term prediction

Biological Process

GO:0006810 transport

Molecular Function

GO:0005215 transporter activity

Cellular Component

GO:0005739 mitochondrion