Protein
MCA_00026_1
Length
649 amino acids
Gene name: CTK1
Description: CTD kinase subunit alpha, Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) that phosphorylates Rpo21p (a subunit of RNA polymerase II) and ribosomal protein Rps2p
Browser: contigA:69057-71101+
RNA-seq: read pairs 874, FPKM 16.6, percentile rank 36.5% (100% = highest expression)
Protein function
| Annotation: | CTK1 | CTD kinase subunit alpha, Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) that phosphorylates Rpo21p (a subunit of RNA polymerase II) and ribosomal protein Rps2p | |
|---|---|---|---|
| KEGG: | K00916 | CTK1 | CTD kinase subunit alpha [EC:2.7.11.22 2.7.11.23] |
| EGGNOG: | 0PGKY | CTK1 | CMGC CDK CRK7 protein kinase |
| SGD closest match: | S000001622 | CTK1 | CTD kinase subunit alpha |
| CGD closest match: | CAL0000185956 | orf19.1619 | Cyclin-dependent serine/threonine protein kinase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_04102_1 | 60.19% | 319 | 1e-129 | MIA_04102_1 |
| A0A0J9XFJ8_GEOCN | 57.53% | 332 | 5e-127 | Similar to Saccharomyces cerevisiae YKL139W CTK1 Catalytic (Alpha) subunit of C-terminal domain kinase I (CTDK-I) OS=Geotrichum candidum GN=BN980_GECA13s02375g PE=4 SV=1 |
| UniRef50_A0A0J9XFJ8 | 57.53% | 332 | 1e-123 | Similar to Saccharomyces cerevisiae YKL139W CTK1 Catalytic (Alpha) subunit of C-terminal domain kinase I (CTDK-I) n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XFJ8_GEOCN |
| A0A170QXZ1_9ASCO | 52.85% | 316 | 4e-106 | Cyclin-dependent serine/threonine protein kinase CTK1 OS=Sugiyamaella lignohabitans GN=CTK1 PE=4 SV=1 |
| A0A060SZL2_BLAAD | 55.21% | 317 | 4e-108 | ARAD1C05566p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C05566g PE=4 SV=1 |
| Q6CDN7_YARLI | 53.92% | 319 | 2e-104 | YALI0B22528p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B22528g PE=4 SV=1 |
| Q5AJH3_CANAL | 50.96% | 314 | 6e-105 | Cyclin-dependent serine/threonine protein kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.1619 PE=4 SV=1 |
| CTK1_YEAST | 42.74% | 365 | 1e-92 | CTD kinase subunit alpha OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CTK1 PE=1 SV=1 |
| A0A1E4TGD2_9ASCO | 47.63% | 317 | 4e-92 | Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_12500 PE=3 SV=1 |
| A0A1E3PIP8_9ASCO | 51.22% | 246 | 1e-78 | Pkinase-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47323 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.1302
Protein family membership
None predicted.
Domains and repeats
-
Domain
1
100
200
300
400
500
649
Detailed signature matches
no IPR
Unintegrated signatures
-
-
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cd07840 (STKc_CDK9_...)
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mobidb-lite (disord...)
Residue annotation
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ATP binding site c...
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active site cd07840
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CDK/cyclin interfa...
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polypeptide substr...
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activation loop (A...
Protein sequence
>MCA_00026_1 MTKRQQRPEPGSKRGYYKHDTSPGPKKRRSRSISPRPSRSPRRRRFDDNDRRRYERSDDSWESRGHHNDNSRDHPSHHQS NNRMPDQRNSRENHIEQREHFRNSSNNRHSYNQGDSRSYSSRNHRQNEPDQSSANNTDRIRNTLDNNSTKRDARYPQYDD EHYEDSSCSSHSHKSPLYDSHKSLKDYKKRSHSPFDRGSRSPPPPRSHHSTTSSKEEHGPSHNNNNNNTSQISFLNKTDS IPSAPSSWKVSNGSSFCERSEKGRGYESSARDRHHQHRHHQYADTPNDRKNYDRDYEKRPRRRTNASLPLIPSTYLEQRT ESIFKRLGQIGEGTYGKVYKAINSKTQARVALKRLRLEAERDGIPITALREIKLLQSINHKNIISLKEILIESSYVFMVF DYADHDLSGILSIPNLNLTPANIKHLFKQSMEALEYIHRHDILHRDIKGSNILVTNSGDIKIADFGLARHRDVMKKNPVY TNRVITLWYRPPELLLGACRYDAEVDIWGMGCILLELYTRSAIFQANDEIGELLAIYQLLGTPSMSNWPDACKLPWYDLL KPSKELPSRIDSALGPIVDKDALKLAKKMLSLNPSARPTAKQVLSSGFFSNLPLPQRPTQLENLTSEWHDFEAKQRKKRS GRASMKEPK
GO term prediction
Biological Process
GO:0006468 protein phosphorylation
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Cellular Component
None predicted.