Protein

MCA_00005_1

Length
1,085 amino acids

Gene name: ISW2A

Description: chromatin-remodeling complex ATPase

Browser: contigA:14666-18048+

RNA-seq: read pairs 2862, FPKM 32.6, percentile rank 55.0% (100% = highest expression)

Protein function

Annotation:ISW2Achromatin-remodeling complex ATPase
KEGG:K11654SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 [EC:3.6.4.-]
EGGNOG:0PG55FG10269.1complex ATPase
SGD closest match:S000005831ISW2ISWI chromatin-remodeling complex ATPase ISW2
CGD closest match:CAL0000192256orf19.4437Chromatin-remodeling complex ATPase

Protein alignments

%idAln lengthE-value
MIA_04083_171.61%10320.0MIA_04083_1
A0A0J9X582_GEOCN67.15%10260.0Chromatin-remodeling complex ATPase OS=Geotrichum candidum GN=BN980_GECA02s08986g PE=3 SV=1
A0A060T225_BLAAD64.76%9990.0Chromatin-remodeling complex ATPase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A04092g PE=3 SV=1
A0A1E3PLE4_9ASCO64.19%9830.0Chromatin-remodeling complex ATPase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_58324 PE=3 SV=1
UniRef50_A0A1E3PLE464.19%9830.0Chromatin-remodeling complex ATPase n=6 Tax=Fungi TaxID=4751 RepID=A0A1E3PLE4_9ASCO
Q6C7A7_YARLI64.31%9750.0Chromatin-remodeling complex ATPase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E02332g PE=3 SV=1
A0A1E4TK67_9ASCO63.47%9910.0Chromatin-remodeling complex ATPase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_748 PE=3 SV=1
A0A1D8PE13_CANAL61.50%10000.0Chromatin-remodeling complex ATPase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.4437 PE=3 SV=1
A0A167DY12_9ASCO67.26%8920.0Chromatin-remodeling complex ATPase OS=Sugiyamaella lignohabitans GN=ISW2 PE=3 SV=1
ISW2_YEAST54.86%10900.0ISWI chromatin-remodeling complex ATPase ISW2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ISW2 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2686

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 100 200 300 400 500 600 700 800 900 1000 1085

Detailed signature matches

  1. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  2. Domain IPR014001
    Helicase superfamily 1/2, ATP-binding domain
    1. PS51192 (HELICASE_A...)
    2. SM00487 (ultradead3)
  3. Domain IPR000330
    SNF2-related, N-terminal domain
    1. PF00176 (SNF2_N)
  4. Domain IPR001650
    Helicase, C-terminal
    1. PS51194 (HELICASE_CTER)
    2. SM00490 (helicmild6)
    3. PF00271 (Helicase_C)
  5. Domain IPR015194
    ISWI, HAND domain
    1. SSF101224 (HAND dom...)
    2. PF09110 (HAND)
  6. Domain IPR009057
    Homeobox domain-like
    1. SSF46689 (Homeodoma...)
  7. Domain IPR001005
    SANT/Myb domain
    1. SM00717 (sant)
  8. Domain IPR015195
    SLIDE domain
    1. PF09111 (SLIDE)
  9. Domain IPR017884
    SANT domain
    1. PS51293 (SANT)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.10.10.60
  3. G3DSA:3.40.50...
  4. G3DSA:3.40.50...
  5. cd00046 (DEXDc)
  6. cd00079 (HELICc)
  7. cd00167 (SANT)
  8. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. putative Mg++ bind...
  3. nucleotide binding...
  4. ATP-binding site c...
  5. DNA binding site c...

Protein sequence

>MCA_00005_1
MTKDTSKNIEDVEFVSTNVSKSEGPIIDVTKDQEVLDKEDQNKPNDSPLPPSELKKRQQTYFVSENKSENKSQFKKDTLN
RFKYLLGLTDLFRHFIKDKAEKDDNFAAVVKEADEKLQEEQLQTSQVSSSTNRRRKTEKEEDAELLQVENEDLEEAGADD
TTVFTSSPAFVHGTLRDYQIQGLNWLISLYQNSISGILADEMGLGKTLQTISFLGYLRYVKGIVGPHIVIVPKSTLDNWE
REFAKWTPEVRTVVIQGDKEMRKDLIANRLKTCDFDVVITSYEIVLREKAVFQKFAWEYIVIDEAHRIKNESSSLSKIIR
LFHSRNRLLITGTPLQNNLHELWSLLNFLLPDVFSESQAFDEWFDNQSQSEEGDQDKVVQQLHRVLQPFLLRRIKSDVEK
SLLPKKEMNVYVGMSPMQVKYYQKILEKDIDAVNGAGNGRGDKTRLLNIVMQLRKCCNHPYLFEGAEPGPPYTTDEHLVF
NSAKMVILDKLLKRCREKGSRVLIFSQMSRMLDILEDYCLFRNFQYNRIDGNTAHPDRIRAIDEYNKPGSEKFVFLLTTR
AGGLGINLTTADTVIIYDSDWNPQADLQAMDRAHRIGQKKQVYVYRFITENAIEEKVLDRAAQKLRLDQLVIQQGRTKTA
NSQASSKEELLSMIQYGAQNVLQAQTSRSQTPSSNGAAPETSTDDDIEAILERGEKKTKELNDRYKTLGLDDLQKFSTEG
SAYEWNGKNFSKVNNTKSKEFTWIGLAKRERKENYSVDGYYKNVLSQNPKAKDVKDDEKGPAIKGPKQINIQDHQFYPSR
FAELQEKELAYFRKQIDYKVPLAPGSDDTLEERQSEQQLEQAEIDSAEPLTEQEINEKEKLSQEGFSTWSRRDFNMFISL
SAKFGRDSLKEIAAGFEDKTEAEVKQYAKVFWKRFKEIDGYERYISQIESGEEKSRKISKQKEYLKQKVESYVAPMQQLQ
LLVPPGSHGRRVYTEEEDRYLLVQMNRFGLDSEGLYEKIRDSIRSSSMFRFDWFLLSRTSAELSRRCHTLLSSVMKEFDD
GAELRSRAETPSELDGVSNGKKRKESSPLTDSRKKKKTSNGVKKN

GO term prediction

Biological Process

GO:0006338 chromatin remodeling
GO:0043044 ATP-dependent chromatin remodeling

Molecular Function

GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005524 ATP binding
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0031491 nucleosome binding

Cellular Component

GO:0005634 nucleus